溴乙酰基胆碱溴化物 | 17139-54-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 溴乙酰基胆碱溴化物
• 英文名称: Bromacetylcholin
• 英文别名: Bromoacetylcholine；trimethyl-(2-bromoacetoxy-ethyl)-ammonium；O-Bromacetyl-cholin；Trimethyl-(2-bromacetoxy-aethyl)-ammonium；Bromessigsaeure-cholinester；2-Bromoacetylcholine；2-(2-bromoacetyl)oxyethyl-trimethylazanium
• CAS: 17139-54-7
• 化学式: C₇H₁₅BrNO₂
• 分子量: 225.106
• InChiKey: BPLURRWZRNOJMR-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于水中

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• WGK Germany：
  3
• RTECS号：
  FZ9902000
• 海关编码：
  2923900090

文献信息

• SULFAMIDES AS TRPM8 MODULATORS
  申请人：Matthews Jay M.

  公开号：US20100160337A1

  公开（公告）日：2010-06-24

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R 1 , R 2 , R 3 , R 4 , R A , and R B are defined herein.

  揭示了用于治疗各种疾病、综合症、症状和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式I表示： 其中Y，R1，R2，R3，R4，RA和RB在此处被定义。
• COLD MENTHOL RECEPTOR-1 ANTAGONISTS
  申请人：Colburn Raymond W.

  公开号：US20120053347A1

  公开（公告）日：2012-03-01

  The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.

  这项发明涉及式(I)的TRPM8拮抗剂。更具体地，本发明涉及某些新颖化合物，制备化合物的方法，组合物，中间体及其衍生物，以及治疗TRPM8介导的疾病的方法。还描述了使用本发明化合物治疗疼痛和各种其他疾病状态或病情的药用和兽医组合物及治疗方法。
• [EN] BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE UTILES EN TANT QUE MODULATEURS DU RÉCEPTEUR TRP M8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010132247A1

  公开（公告）日：2010-11-18

  The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

  本发明涉及苯并咪唑衍生物，含有它们的药物组合物以及它们在治疗由TRP M8（瞬时受体电位M8通道）调节的疾病和症状中的应用。更具体地说，本发明的化合物在治疗炎症性疼痛、炎症性过敏症、炎症性过敏性疾病、神经病性疼痛、神经性寒冷触痛、炎症性体感过敏症、炎症性内脏过敏症、受寒加重的心血管疾病、焦虑和抑郁方面具有用处。
• Cold Menthol Receptor Antagonists
  申请人：Colburn Raymond W.

  公开号：US20100048589A1

  公开（公告）日：2010-02-25

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R 1 , R 2 , and R 3 are defined herein.

  揭示了用于治疗各种疾病、综合症、症状和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式 I 表示：其中 A、B、L、Q、R1、R2 和 R3 在此处定义。
• IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS
  申请人：Macielag Mark J.

  公开号：US20120149699A1

  公开（公告）日：2012-06-14

  Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R 1 , R 2 , and are defined herein.

  揭示了用于治疗各种疾病、综合征、状况和障碍的化合物、组合物和方法，包括疼痛。这些化合物由以下的化学式I代表：其中Y、R1、R2和在此有定义。