3,3'-dithiobis(N-pentylpropanamide) | 33311-97-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3,3'-dithiobis(N-pentylpropanamide)
• 英文别名: N,N'-dipentyl-3,3'-disulfanediyl-bis-propionamide；N,N'-bis-(n-pentyl)-3,3'-dithiodipropionamide；3-[[3-oxo-3-(pentylamino)propyl]disulfanyl]-N-pentylpropanamide
• CAS: 33311-97-6
• 化学式: C₁₆H₃₂N₂O₂S₂
• 分子量: 348.574
• InChiKey: SFLWQMHYESCFMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,3'-dithiobis(N-pentylpropanamide) 在 氯 作用下， 以 乙酸乙酯 为溶剂， 生成 2-pentylisothiazol-3(2H)-one
  参考文献：
  名称：

  Lewis,S.N. et al., Journal of Heterocyclic Chemistry, 1971, vol. 8, p. 571 - 580

  摘要：

  DOI：
• 作为产物：
  描述：

  3,3'-二氢氧啉酸 在 吡啶 、 氯化亚砜 作用下， 生成 3,3'-dithiobis(N-pentylpropanamide)
  参考文献：
  名称：

  Lewis,S.N. et al., Journal of Heterocyclic Chemistry, 1971, vol. 8, p. 571 - 580

  摘要：

  DOI：

文献信息

• S-beta-dicarbonyl substituted beta-thioacrylamide biocides and fungicides
  申请人：Rohm and Haas Company

  公开号：US05118681A1

  公开（公告）日：1992-06-02

  S-beta-dicarbonyl substituted beta-thioacrylamide compounds have been discovered to be useful as biocides and fungicides. Compositions comprising the compound and isothiazolin-3-ones and/or carries, methods of preparation of the compounds and methods of using the compounds and compositions are also disclosed.

  S-beta-二羰基取代的β-硫丙烯酰胺化合物已被发现可用作生物杀菌剂和杀真菌剂。该化合物和异噻唑烷-3-酮和/或载体的组合物，以及制备该化合物和组合物的方法和使用该化合物和组合物的方法也被揭示。
• S-substituted beta-thioacrylamides and their use as microbicides
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0410726A1

  公开（公告）日：1991-01-30

  S-substituted beta-thioacrylamide compounds have been discovered to be useful as microbicides, particularly fungicides. Compositions comprising said compounds and isothiazolin-3-ones and/or carriers, methods of preparation of the compounds and methods of using the compounds and compositions are also disclosed.

  已发现 S-取代β-硫代丙烯酰胺化合物可用作杀微生物剂，特别是杀真菌剂。此外，还公开了包含上述化合物和异噻唑啉-3-酮和/或载体的组合物、化合物的制备方法以及化合物和组合物的使用方法。
• Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones
  作者：Frank J. Dekker、Massimo Ghizzoni、Nanette van der Meer、Rosalina Wisastra、Hidde J. Haisma

  DOI：10.1016/j.bmc.2008.12.008

  日期：2009.1

  Small molecule HAT inhibitors are useful tools to unravel the role of histone acetyl transferases (HATs) in the cell and have relevance for oncology. We present a systematic investigation of the inhibition of the HAT p300/CBP Associated Factor (PCAF) by isothiazolones with different substitutions. 5-chloroisothiazolones proved to be the most potent inhibitors of PCAF. The growth inhibition of 4 different cell lines was studied and the growth of two cell lines (A2780 and HEK 293) was inhibited at micromolar concentrations by 5-chloroisothiazolones. Furthermore, the 5-chloroisothiazolone preservative Kathon (TM) CG that is used in cosmetics inhibited PCAF and the growth of cell lines A2780 and HEK 293, which indicates that this preservative should be applied with care. (C) 2008 Elsevier Ltd. All rights reserved.
• US5118681A
  申请人：——

  公开号：US5118681A

  公开（公告）日：1992-06-02
• Lewis,S.N. et al., Journal of Heterocyclic Chemistry, 1971, vol. 8, p. 571 - 580
  作者：Lewis,S.N. et al.

  DOI：——

  日期：——