4-(2-((4-Methoxyphenyl)thio)ethyl)pyridine | 292617-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-((4-Methoxyphenyl)thio)ethyl)pyridine
• 英文别名: 4-[2-(4-Methoxy-phenylsulfanyl)-ethyl]-pyridine；4-[2-(4-methoxyphenyl)sulfanylethyl]pyridine
• CAS: 292617-85-7
• 化学式: C₁₄H₁₅NOS
• 分子量: 245.345
• InChiKey: IUWQYMDPRUPDGB-UHFFFAOYSA-N

物化性质

• 沸点：
  405.0±35.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙烯基吡啶 、 4-甲氧基苯硫酚 在 Amberlyst-15 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以97%的产率得到4-(2-((4-Methoxyphenyl)thio)ethyl)pyridine
  参考文献：
  名称：

  Amberlyst-15©: An efficient heterogeneous reusable catalyst for selective anti-Markovnikov addition of thiols to alkenes/alkynes and for thiolysis of epoxides

  摘要：

  The anti-Markovnikov addition of thiols to alkenes/alkynes and thiolysis of epoxides is described using Amberlyst-15(C) as a selective, commercially available, inexpensive and reusable catalyst. The products like diorganyl sulphides, beta-hydroxy sulphides and phenyl(styryl)sulfanes were obtained in good to excellent yields in short reaction time and with high regio-selectivity. The catalyst was reused up to five consecutive recycles without any loss in its catalytic activity. The developed methodology is a metal free protocol for C-S bond formation reaction with high atom economy. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2013.06.032

文献信息

• Methods for treating vascular diseases
  申请人：Peterson T. Randall

  公开号：US20070010541A1

  公开（公告）日：2007-01-11

  The invention includes methods of treating or preventing vascular disease or promoting vascular growth or development. The methods can be used in the treatment of diseases associated with ischemia, such as heart attack and stroke.
• Change of the Load State of Mhc Molecules
  申请人：Falk Kirsten

  公开号：US20070280957A1

  公开（公告）日：2007-12-06

  The present invention relates to methods for changing the load state of MHC molecules with ligands, the change in the load state being catalysed by a compound of formulae I, IA, II, III or IV1 to IV3. The invention relates further to the use of compounds of formulae I, IA, II, III or IV1 to IV3 or to the use of MHC molecules loaded with ligands, which molecules can be prepared by a method according to the invention, for the treatment of disorders or conditions that are associated with various pathologically excessive or absent immune responses and also for triggering tumour-specific, pathogen-specific or autoreactive immune responses. The invention additionally relates to the use of such compounds for the treatment and diagnosis of cancer, infectious diseases, autoimmune diseases and for attenuating aggressive immune reactions, as well as to the preparation of a vaccine or of a pharmaceutical composition for the treatment of the mentioned disorders or conditions.
• Composition and methods useful in preventing cardiac hypertrophy
  申请人：Chin Michael

  公开号：US20090054500A1

  公开（公告）日：2009-02-26

  The present invention is directed to compositions and methods that can be used for preventing the hypertrophy of cardiac cells. The compositions and methods involve the use of compounds that lead to an increase in the cellular activity of the transcription factor CHF1.
• US20140261212A1
  申请人：——

  公开号：US20140261212A1

  公开（公告）日：2014-09-18
• NOVEL GERM CELL ABLATION COMPOUNDS AND USES THEREOF
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US20170079252A1

  公开（公告）日：2017-03-23

  Provided herein are methods of sterilizing fish by contacting an embryonic or juvenile fish with a compound of formula (I). In some embodiments, the compound is primordazine or a derivative thereof.