1-propyl-3,4-dihydro-2H-pyridine | 93101-22-5

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-propyl-3,4-dihydro-2H-pyridine
• CAS: 93101-22-5
• 化学式: C₈H₁₅N
• 分子量: 125.214
• InChiKey: NETKAERQFCCIAE-UHFFFAOYSA-N

物化性质

• 沸点：
  183.9±10.0 °C(Predicted)
• 密度：
  0.864±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  p-chlorobenzenesulfonyl azide 、 1-propyl-3,4-dihydro-2H-pyridine 以 乙醚 为溶剂， 反应 1.0h， 以68%的产率得到4-chloro-N-(1-propylpiperidin-2-ylidene)benzenesulfonamide
  参考文献：
  名称：

  Warren, Brent K.; Knaus, Edward E., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1379 - 1381

  摘要：

  DOI：

文献信息

• [EN] N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY<br/>[FR] DÉRIVÉS DE N-PYRIDYL ACÉTAMIDE UTILISÉS COMME INHIBITEURS DE LA VOIE DE SIGNALISATION WNT
  申请人：REDX PHARMA PLC

  公开号：WO2016055786A1

  公开（公告）日：2016-04-14

  This invention relates to compounds. More specifically, the invention relates to compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In addition the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the Wnt signalling pathway, for example treating cancer, sarcoma, melanoma, skin cancer, haematological tumors, lymphoma, carcinoma, and leukemia; or enhancing the effectiveness of an anti-cancer treatment.

  这项发明涉及化合物。更具体地，该发明涉及作为Wnt信号通路抑制剂的化合物。具体来说，该发明考虑了Porcupine（Porcn）的抑制剂。此外，该发明考虑了制备这些化合物的过程以及这些化合物的用途。因此，该发明的化合物可用于治疗由Wnt信号通路介导的疾病，例如治疗癌症、肉瘤、黑色素瘤、皮肤癌、血液肿瘤、淋巴瘤、癌症和白血病；或增强抗癌治疗的有效性。
• SPIRO-CONDENSED INDOLE COMPOUNDS AS EHMT2 INHIBITORS
  申请人：Epizyme Inc

  公开号：EP4105203A1

  公开（公告）日：2022-12-21

  The present disclosure relates to substituted fused bi- or tri- heterocyclic compounds of formula (Va) to (Vf). The present disclosure also relates to pharmaceutical compositions containing these compounds. Said compounds are for use in methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2.

  本公开涉及式（Va）至（Vf）的取代融合二或三杂环化合物。本公开还涉及含有这些化合物的药物组合物。所述化合物用于通过抑制选自 EHMT1 和 EHMT2 的甲基转移酶来治疗疾病（例如镰状细胞贫血）的方法。
• WARREN, BRENT K.;KNAUS, EDWARD E., J. HETEROCYCL. CHEM., 25,(1988) N, C. 1379-1381
  作者：WARREN, BRENT K.、KNAUS, EDWARD E.

  DOI：——

  日期：——
• N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY
  申请人：Redx Pharma PLC

  公开号：EP3204378A1

  公开（公告）日：2017-08-16
• [EN] NOVEL QUINOLINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT<br/>[FR] NOUVEAU DÉRIVÉ DE QUINOLÉINE OU SON SEL PHARMACEUTIQUEMENT ACCEPTABLE, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT COMME INGRÉDIENT ACTIF<br/>[KO] 신규한 퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물
  申请人：UNIV KOREA RES & BUS FOUND

  公开号：WO2020040581A1

  公开（公告）日：2020-02-27

  본 발명은 신규한 퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명의 화학식 1로 표시되는 화합물 또는 이의 약학적으로 허용가능한 염, 또는 그 용매화물은 HSP90과 HSF-1의 complex 구조에 영향을 미치지 않아 HSF-1의 활성화나 HSP gene들의 발현을 유도하지 않으므로 효과적으로 암세포의 사멸을 촉진할 수 있어, 항암제의 유효성분으로 사용될 수 있다.