5-cyclohexyl-2,3-dihydro-1H-indole-2,3-dione  | 72685-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-cyclohexyl-2,3-dihydro-1H-indole-2,3-dione
• 英文别名: 5-cyclohexyl-1H-indole-2,3-dione；5-Cyclohexylindoline-2,3-dione
• CAS: 72685-98-4
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: JDNQFEYDYPKVSA-UHFFFAOYSA-N

物化性质

• 熔点：
  173-174 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-cyclohexyl-2,3-dihydro-1H-indole-2,3-dione  在 五氯化磷 作用下， 以 1,4-二氧六环 、 苯 为溶剂， 反应 0.5h， 生成 diethyl 2-(5-cyclohexyl-3-oxo-1,3-dihydro-2H-indol-2-ylidene)malonate
  参考文献：
  名称：

  Synthesis and antibacterial activity of pyridazino[4,3-b]indole-4-carboxylic acids carrying different substituents at N-2

  摘要：

  The synthesis and the in vitro evaluation of antibacterial activity of new pyridazino[4,3-b]indole-4-carboxylic acids 2-4, 6 against some selected representative of Gram-positive and Gram-negative bacteria are reported. The role of the lipophilicity in the modulation of the antibacterial activity of the tested compounds is discussed. All the synthesized compounds appear quite weak against Gram-positive bacteria, whereas have no significant activity against Gram-negative bacteria. Only derivative 2g possesses an interesting activity against Gram-positive bacteria. (C) 2002 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01173-9
• 作为产物：
  描述：

  N-(4-cyclohexylphenyl)-2-hydroxymino-acetamide 在 甲烷磺酸 作用下， 反应 2.0h， 生成 5-cyclohexyl-2,3-dihydro-1H-indole-2,3-dione 
  参考文献：
  名称：

  Synthesis and antibacterial activity of pyridazino[4,3-b]indole-4-carboxylic acids carrying different substituents at N-2

  摘要：

  The synthesis and the in vitro evaluation of antibacterial activity of new pyridazino[4,3-b]indole-4-carboxylic acids 2-4, 6 against some selected representative of Gram-positive and Gram-negative bacteria are reported. The role of the lipophilicity in the modulation of the antibacterial activity of the tested compounds is discussed. All the synthesized compounds appear quite weak against Gram-positive bacteria, whereas have no significant activity against Gram-negative bacteria. Only derivative 2g possesses an interesting activity against Gram-positive bacteria. (C) 2002 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01173-9

文献信息

• Synthesis of substituted isatins
  作者：Larry L. Klein、Michael D. Tufano

  DOI：10.1016/j.tetlet.2012.12.035

  日期：2013.2

  Isatins are valuable intermediates for heterocyclic chemistry. Most of the common methods for their production are less than adequate when the number and lipophilicity of substituents on the targeted isatin are increased. Our group desired such molecules and identified an alternative method for their production.

  靛红是杂环化学的重要中间体。当目标靛红上取代基的数量和亲脂性增加时，大多数常用的生产方法都不够充分。我们的小组需要这样的分子，并确定了生产它们的替代方法。
• Composition containing an oxoindole compound
  申请人：Aktiebolaget Astra

  公开号：US05585378A1

  公开（公告）日：1996-12-17

  The present invention relates to an oxindole compound having the formula 5-cyclohexyl-1,3-dihydro-1-[2-[4-(phenylmethyl)-1-piperazinyl]ethyl]-2H-in dol-2-one for the prevention or treatment of cognitive dysfunctions.

  本发明涉及一种具有下列结构式的氧吲哚化合物，用于预防或治疗认知功能障碍：5-环己基-1,3-二氢-1-[2-[4-(苯甲基)-1-哌嗪基]乙基]-2H-吲哚-2-酮。
• PLAZZI P. V.; VITTO M.; BRANCA C., ATENEO PARM. ACTA NATUR., 1979, 15, NO 1, 49-55
  作者：PLAZZI P. V.、 VITTO M.、 BRANCA C.

  DOI：——

  日期：——
• ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Astra Aktiebolag

  公开号：EP0624156A1

  公开（公告）日：1994-11-17
• 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE
  申请人：Astra Aktiebolag

  公开号：EP0703901A1

  公开（公告）日：1996-04-03