2-(4-benzo[1,3]dioxol-5-yl-1H-pyrazol-3-yl)-6-methyl-pyridine | 676261-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-(4-benzo[1,3]dioxol-5-yl-1H-pyrazol-3-yl)-6-methyl-pyridine
• 英文别名: 2-[4-(1,3-benzodioxol-5-yl)-1H-pyrazol-5-yl]-6-methylpyridine
• CAS: 676261-93-1
• 化学式: C₁₆H₁₃N₃O₂
• 分子量: 279.298
• InChiKey: GOFLIWZPAVMGLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-benzo[1,3]dioxol-5-yl-1H-pyrazol-3-yl)-6-methyl-pyridine 、 溴乙腈 在 sodium methylate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 以88%的产率得到[4-benzo[1,3]dioxol-5-yl-3-(6-methyl-pyridin-2-yl)-pyrazol-1-yl]-acetonitrile
  参考文献：
  名称：

  [EN] PYRAZOLES AND METHODS OF MAKING AND USING THE SAME
  [FR] PYRAZOLES ET LEURS METHODES DE FABRICATION ET D'UTILISATION

  摘要：

  公开号：

  WO2004072033A3

文献信息

• Novel pyrazole compounds as transforming growth factor (TGF) inhibitors
  申请人：Pfizer Inc

  公开号：US20040116474A1

  公开（公告）日：2004-06-17

  Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-&bgr; signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

  本发明涉及新型吡唑化合物，包括其衍生物，以及其制备的中间体，含有它们的制药组合物和它们的药用用途。本发明的化合物是转化生长因子（“TGF”）-β信号通路的有效抑制剂。它们在治疗各种与TGF相关的疾病状态中有用，包括癌症和纤维化疾病。
• Pyrazoles and methods of making and using the same
  申请人：Lee Wen-Cherng

  公开号：US20060264440A1

  公开（公告）日：2006-11-23

  The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).

  该发明基于发现，公式I的化合物具有意外的高亲和力，可用作Alk 5和/或Alk 4的拮抗剂，以预防和/或治疗多种疾病，包括纤维化疾病。在一种实施例中，该发明涉及公式I（I）的化合物。
• NOVEL PYRAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
  申请人：Munchhof J. Michael

  公开号：US20070117850A1

  公开（公告）日：2007-05-24

  Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)- signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

  本发明涉及新型吡唑化合物，包括其衍生物，以及其制备的中间体，含有它们的制药组合物和它们的药用用途。本发明化合物是转化生长因子（“TGF”）信号通路的有效抑制剂。它们在治疗各种TGF相关疾病状态方面非常有用，包括癌症和纤维化疾病。
• NEW PYRAZOLE DERIVATIVES AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP2165708A2

  公开（公告）日：2010-03-24

  Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ('TGF')-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.

  本发明描述了新型吡唑化合物（包括其衍生物）、制备它们的中间体、含有它们的药物组合物及其药用用途。本发明的化合物是转化生长因子（'TGF'）-β 信号通路的强效抑制剂。它们可用于治疗各种与 TGF 相关的疾病，例如癌症和纤维化疾病。
• PYRAZOLES AND METHODS OF MAKING AND USING THE SAME
  申请人：Biogen Idec MA Inc.

  公开号：EP1596656A2

  公开（公告）日：2005-11-23