JAK3 Inhibitor VI | 623175-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: JAK3 Inhibitor VI
• 英文别名: methanesulfonic acid;(3Z)-5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one
• CAS: 623175-20-2
• 化学式: C19H17N3O4S
• 分子量: 383.4
• InChiKey: ZUDPNBZMAJGYTE-HYMQDMCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS
  申请人：TUDAG TU Dresden Aktiengesellschaft

  公开号：EP3578981B1

  公开（公告）日：2021-10-27
• [EN] ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS<br/>[FR] TRAITEMENT ANTICANCÉREUX DE SUJETS PRÉSÉLECTIONNÉS ET PROCÉDÉS DE CRIBLAGE POUR IDENTIFIER DES SUJETS SENSIBLES
  申请人：UNIV DRESDEN TECH

  公开号：WO2019233779A1

  公开（公告）日：2019-12-12

  The invention provides methods of screening a subject for a proliferative disease risk factor which comprises detecting the presence or absence of target cells. The presence of target cells in the subject indicates the subject is at increased risk of developing a proliferative disease or recurrence of a previously treated proliferative disease and defines a new patient subgroup susceptible for treatment with selected anti-proliferative compounds. Methods of screening compounds for the treatment of proliferative diseases based on the presence of target cells and the expression of certain biomarkers by said target cells are also disclosed, along with appropriate compounds and their use in methods of treating such diseases.