t-butyldimethylsilyl 3-phenylpropionate | 78324-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: t-butyldimethylsilyl 3-phenylpropionate
• 英文别名: 3-phenylpropionic acid, t-butyldimethylsilyl ester；3-phenylpropionic acid,t-butyldimethylsilyl ester；tert-Butyl(dimethyl)silyl 3-phenylpropanoate；[tert-butyl(dimethyl)silyl] 3-phenylpropanoate
• CAS: 78324-01-3
• 化学式: C₁₅H₂₄O₂Si
• 分子量: 264.44
• InChiKey: DMEANXAVVZKYTA-UHFFFAOYSA-N

物化性质

• 保留指数：
  1653

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2931900090

反应信息

• 作为反应物：
  描述：

  1-碘丁烷 、 t-butyldimethylsilyl 3-phenylpropionate 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以91%的产率得到苯戊酮
  参考文献：
  名称：

  Ooi; Ooi, Takashi; Sugimoto, Heterocycles, 2001, vol. 54, # 2, p. 593 - 596

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(叔丁基二甲基硅氧基)-1-甲氧基乙烯 、 3-苯基丙酸 以 乙腈 为溶剂， 反应 0.25h， 以83%的产率得到t-butyldimethylsilyl 3-phenylpropionate
  参考文献：
  名称：

  O-Silylated Ketene Acetal Chemistry¹; A Mild and Efficientt-Butyldimethylsilylating Agent

  摘要：

  DOI：

  10.1055/s-1981-29478

文献信息

• Preparation of silyl polyenol ethers by carbonyl olefination of silyl esters
  作者：Takeshi Takeda、Tatsuya Fukada、Akira Tsubouchi

  DOI：10.1016/j.tetlet.2014.01.040

  日期：2014.2

  Silyl enol ethers were produced by the carbonyl olefination of silyl esters with titanium carbene complexes generated by the desulfurizative titanation of thioacetals. The regioselective preparation of silyl dienol and trienol ethers has been achieved by using unsaturated silyl esters and thioacetals.

  甲硅烷基烯醇醚是通过将甲硅烷基酯的羰基烯化与硫代乙缩醛的脱硫钛化反应生成的钛碳烯配合物而制得的。甲硅烷基二烯醇和三烯醇醚的区域选择性制备已经通过使用不饱和甲硅烷基酯和硫代缩醛实现。
• Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05455242A1

  公开（公告）日：1995-10-03

  The present invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene or oxygen, sulfur or NR.sub.4 or NCOR.sub.5 wherein R.sub.4 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.5 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group; R.sub.3 is hydrogen or --CH.sub.2 OC(O)C(CH.sub.3).sub.3 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or --CH.sub.2 OC(O)--C(CH.sub.3).sub.3 ; and n is an integer 1 to 3, which are useful as inhibitors of enkephalinase and ACE.

  本发明涉及以下结构的化合物 ##STR1## 其中B.sub.1和B.sub.2分别独立地是氢；羟基；--OR.sub.2 其中R.sub.2是C.sub.1 -C.sub.4烷基或Ar--Y基团，其中Ar是芳基，Y是氢或C.sub.1 -C.sub.4烷基；或者，当B.sub.1和B.sub.2连接到相邻的碳原子时，B.sub.1和B.sub.2可以与所述相邻碳原子一起形成苯环或亚甲二氧基；A为键，亚甲基或氧、硫或NR.sub.4或NCOR.sub.5，其中R.sub.4为氢，C.sub.1 -C.sub.4烷基或Ar--Y--基团，R.sub.5为--CF.sub.3，C.sub.1 -C.sub.10烷基或Ar--Y--基团；R.sub.3为氢或--CH.sub.2 OC(O)C(CH.sub.3).sub.3；R.sub.1为氢，C.sub.1 -C.sub.4烷基或--CH.sub.2 OC(O)--C(CH.sub.3).sub.3；n为1到3的整数，这些化合物可用作脑啡肽酶和ACE的抑制剂。
• The Utility of<i>t</i>-Butyldimethylsilane as an Effective Silylation Reagent for the Protection of Functional Groups
  作者：Keiji Yamamoto、Makoto Takemae

  DOI：10.1246/bcsj.62.2111

  日期：1989.6

  Treatment of compounds containing functional groups, such as alcohols, amines, and carboxylic acids, with t-butyldimethylsilane in the presence of a catalytic amount of palladium on carbon is described to provide a new, convenient method for the introduction of a t-butyldimethylsilyl (TBDMS) group.

  描述了在催化量的钯碳存在下用叔丁基二甲基硅烷处理含有官能团的化合物，如醇、胺和羧酸，提供了一种新的、方便的引入叔丁基二甲基甲硅烷基的方法。 TBDMS) 组。
• Carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05472959A1

  公开（公告）日：1995-12-05

  The invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene or oxygen, sulfur, NR.sub.4 or NCOR.sub.5 wherein R.sub.4 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.5 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group; R.sub.3 is hydrogen or --CH.sub.2 OC(O)C(CH.sub.3).sub.3 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or --CH.sub.2 OC(O)--C(CH.sub.3).sub.3 ; and n is an integer 1 to 3, that are useful as inhibitors of enkephalinase and ACE.

  本发明涉及式子##STR1##的化合物，其中B.sub.1和B.sub.2分别独立地为氢; 羟基; --OR.sub.2，其中R.sub.2是C.sub.1-C.sub.4烷基或Ar--Y基团，其中Ar是芳基，Y是氢或C.sub.1-C.sub.4烷基; 或者，当B.sub.1和B.sub.2附加在相邻的碳原子上时，B.sub.1和B.sub.2可以与所述相邻碳原子一起取代成苯环或亚甲二氧基; A是键，亚甲基或氧，硫，NR.sub.4或NCOR.sub.5，其中R.sub.4是氢，C.sub.1-C.sub.4烷基或Ar--Y--基团，R.sub.5是--CF.sub.3，C.sub.1-C.sub.10烷基或Ar--Y--基团; R.sub.3是氢或--CH.sub.2OC（O）C（CH.sub.3）.sub.3; R.sub.1是氢，C.sub.1-C.sub.4烷基或--CH.sub.2OC（O）--C（CH.sub.3）.sub.3; n是1到3的整数，这些化合物对于脑啡肽酶和ACE的抑制剂是有用的。
• Carboxyalkyl tricylic derivatives useful as inhibitors of enkephalinase
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05488047A1

  公开（公告）日：1996-01-30

  The present invention relates to compounds of the formula ##STR1## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C.sub.1 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene or oxygen, sulfur or NR.sub.4 or NCOR.sub.5 wherein R.sub.4 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.5 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group; R.sub.3 is hydrogen or --CH.sub.2 OC(O)C(CH.sub.3).sub.3 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl or --CH.sub.2 OC(O)--C(CH.sub.3).sub.3 ; and n is an integer 1 to 3, which are useful as inhibitors of enkephalinase and ACE.

  本发明涉及公式##STR1##的化合物，其中B.sub.1和B.sub.2各自独立地为氢；羟基；--OR.sub.2，其中R.sub.2为C.sub.1-C.sub.4烷基或Ar-Y基，其中Ar为芳基，Y为氢或C.sub.1-C.sub.4烷基；或者，当B.sub.1和B.sub.2附着在相邻的碳原子上时，B.sub.1和B.sub.2可以与所述相邻的碳原子一起形成苯环或亚甲二氧基；A是键，亚甲基或氧、硫或NR.sub.4或NCOR.sub.5，其中R.sub.4为氢、C.sub.1-C.sub.4烷基或Ar-Y基，R.sub.5为--CF.sub.3，C.sub.1-C.sub.10烷基或Ar-Y基；R.sub.3为氢或--CH.sub.2OC(O)C(CH.sub.3).sub.3；R.sub.1为氢、C.sub.1-C.sub.4烷基或--CH.sub.2OC(O)--C(CH.sub.3).sub.3；n为整数1至3，这些化合物可用作脑啡肽酶和ACE的抑制剂。