2-ethyl-6-phenylpyrimidin-4-one | 52421-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-ethyl-6-phenylpyrimidin-4-one
• 英文别名: 2-ethyl-6-phenylpyrimidin-4(3H)-one；2-ethyl-4-phenyl-1,6-dihydropyrimidin-6-one；2-ethyl-4-phenyl-1,6-dihydro-6-pyrimidone；2-ethyl-6-phenyl-3H-pyrimidin-4-one；2-Aethyl-6-phenyl-3H-pyrimidin-4-on；2-ethyl-6-phenyl-4(3H)-pyrimidinone；2-ethyl-4-phenyl-1H-pyrimidin-6-one
• CAS: 52421-76-8
• 化学式: C₁₂H₁₂N₂O
• mdl: MFCD01852328
• 分子量: 200.24
• InChiKey: CEYSKKBCEBTBFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-6-phenylpyrimidin-4-one 在 三氯氧磷 作用下， 反应 2.0h， 以99%的产率得到4-Chloro-2-ethyl-6-phenyl-pyrimidine
  参考文献：
  名称：

  Synthesis and Reactivity of Disubstituted 4,4′-Bipyrimidines: Preparation of a New Pentadentate Ligand

  摘要：

  研究了2，2'-二取代6，6'-二苯基4，4'-联吡啶(bpm)的合成及其氧化和溴化反应性。报道了通过模板反应从2-溴甲基-4，4'-联吡啶单元制备五齿配体的方法。

  DOI：

  10.1055/s-1993-25886
• 作为产物：
  描述：

  N-Propionyl-α-benzoylacetamid 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 0.25h， 以91%的产率得到2-ethyl-6-phenylpyrimidin-4-one
  参考文献：
  名称：

  A facile synthesis of pyrimidin-4-ones

  摘要：

  A facile synthesis of 2,6-disubstituted pyrimidin-4-ones and 2,5,6-trisubstituted pyrimidin-4-ones from commercially available materials with application of microwave technology in key steps is described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.096

文献信息

• 一种甲基酮衍生物及其制备方法与应用
  申请人：苏州大学

  公开号：CN106496130B

  公开（公告）日：2019-09-20

  本发明公开了一种甲基酮衍生物及其制备方法与应用，将酮衍生物、有机过氧化物溶于溶剂中，于80‑130℃反应，获得甲基嘧啶酮和甲基吡啶酮衍生物。本发明使用酮衍生物为起始物，原料易得、种类很多；利用本发明的方法得到的产物类型多样，既可以直接使用、又可以用于其他进一步的反应。本发明方法无金属参与，适合于制药工艺。本发明方法路线简短、反应条件温和、反应操作和后处理过程简单、产率较高，适合于规模化生产。
• Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
  申请人：Dr. Reddy's Research Foundation

  公开号：US06310069B1

  公开（公告）日：2001-10-30

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及新型抗糖尿病化合物及其互变异构体、衍生物、立体异构体、多晶形态、药用可接受盐、药用可接受溶剂和含有它们的药用可接受组合物。本发明特别涉及一般式(I)的新型噁唑烷二酮衍生物及其药用可接受盐、药用可接受溶剂和含有它们的药用组合物。
• Heterocyclic compounds, process for their preparation and pharmaceutical
  申请人：Dr. Reddy's Research Foundation

  公开号：US05885997A1

  公开（公告）日：1999-03-23

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

  本发明涉及新型抗糖尿病化合物，它们的互变异构形式，它们的衍生物，它们的立体异构体，它们的多晶形态，它们的药学上可接受的盐，它们的药学上可接受的溶剂合物以及含有它们的药学上可接受的组合物。本发明特别涉及一般式（I）的新型噁唑烷二酮衍生物，以及它们的药学上可接受的盐、药学上可接受的溶剂和含有它们的药用组合物。
• Novel heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
  申请人：DR. REDDY'S RESEARCH FOUNDATION & REDDY- CHEMINOR, INC.

  公开号：US20010031759A1

  公开（公告）日：2001-10-18

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. 1

  本发明涉及一种新型抗糖尿病化合物，其互变异构体、衍生物、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化合物以及含有它们的药学上可接受的组合物。本发明特别涉及一种一般式（I）的新型噁唑烷二酮衍生物及其药学上可接受的盐、药学上可接受的溶剂化合物和含有它们的药物组合物。1
• New monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
  申请人：Gurram Madhavan Ranga

  公开号：US20060089500A1

  公开（公告）日：2006-04-27

  The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds, their analogs, their derivatives, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The present invention also relates to novel intermediates, processes for their preparation and their use in the preparation of compounds of formula (I).

  本发明涉及新型抗肥胖和降低胆固醇的化合物，它们的衍生物、类似物、互变异构体、立体异构体、多形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。更具体地，本发明涉及一般式（I）的新型β-芳基-α-氧代取代烷基羧酸，它们的衍生物、类似物、互变异构体、立体异构体、多形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。本发明还涉及上述新型化合物、类似物、衍生物、互变异构体、立体异构体、多形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药物组合物的制备方法。本发明还涉及新型中间体，其制备方法及其在式（I）化合物的制备中的应用。