1-(1-phenylpropyl)-1H-pyrrole | 1197029-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-phenylpropyl)-1H-pyrrole
• 英文别名: 1-(1-Phenylpropyl)pyrrole
• CAS: 1197029-72-3
• 化学式: C₁₃H₁₅N
• 分子量: 185.269
• InChiKey: QTDZQEAANFQYEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  3-吡咯啉 、 苯丙酮 在 苯甲酸 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以86%的产率得到1-(1-phenylpropyl)-1H-pyrrole
  参考文献：
  名称：

  Formation of N-Alkylpyrroles via Intermolecular Redox Amination

  摘要：

  A wide variety of aldehydes, ketones, and lactols undergo redox amination when allowed to react with 3-pyrroline in the presence of a mild Bronsted acid catalyst. This reaction utilizes the inherent reducing power of 3-pyrroline to perform the equivalent of a reductive amination to form alkyl pyrroles. In doing so, the reaction avoids stoichiometric reducing agents that are typically associated with reductive aminations. Moreover, the redox amination protocol allows access to alkyl. pyrroles that cannot be made via standard reductive amination.

  DOI：

  10.1021/ja907357g

文献信息

• DIARYLTRIAZOLMETHYLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
  申请人：BARTH Francis

  公开号：US20080293794A1

  公开（公告）日：2008-11-27

  The invention concerns compounds of formula (I): Wherein X, R 1 , R 2 , R 3 and R 4 are as described herein. The invention also concerns a method for preparing same and the therapeutic use thereof.

  该发明涉及式(I)的化合物：其中X，R1，R2，R3和R4如本文所述。该发明还涉及一种制备该化合物的方法以及其治疗用途。
• RED ORGANIC ELECTROLUMINESCENCE ELEMENT
  申请人：Ikeda Kiyoshi

  公开号：US20090033218A1

  公开（公告）日：2009-02-05

  Provided is an organic electroluminescence device in which a single or a plurality of thin organic layers including at least a light emitting layer are sandwiched between an anode and a cathode. At least one of the thin organic layers includes: (A) a perylene compound having at least one halogen atom in its molecule; and (B) a compound having a fused aromatic ring having a ring carbon atoms of 12 to 15. The organic EL device has a high luminous efficiency and a long lifetime and is capable of emitting light having a color range of from an orange color to a red color.
• US7781471B2
  申请人：——

  公开号：US7781471B2

  公开（公告）日：2010-08-24
• Formation of <i>N</i>-Alkylpyrroles via Intermolecular Redox Amination
  作者：Nirmal K. Pahadi、Miranda Paley、Ranjan Jana、Shelli R. Waetzig、Jon A. Tunge

  DOI：10.1021/ja907357g

  日期：2009.11.25

  A wide variety of aldehydes, ketones, and lactols undergo redox amination when allowed to react with 3-pyrroline in the presence of a mild Bronsted acid catalyst. This reaction utilizes the inherent reducing power of 3-pyrroline to perform the equivalent of a reductive amination to form alkyl pyrroles. In doing so, the reaction avoids stoichiometric reducing agents that are typically associated with reductive aminations. Moreover, the redox amination protocol allows access to alkyl. pyrroles that cannot be made via standard reductive amination.