2-(4-氟苯氧基)-N,N-二甲基乙胺 | 2401-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(4-氟苯氧基)-N,N-二甲基乙胺
• 英文名称: N-<2-(4-Fluorphenoxy)-aethyl>-dimethylamin
• 英文别名: N,N-Dimethyl-2-<4-fluor-phenoxy>-aethylamin；2-(4-fluorophenoxy)-N,N-dimethylethanamine
• CAS: 2401-45-8
• 化学式: C₁₀H₁₄FNO
• mdl: MFCD16302291
• 分子量: 183.226
• InChiKey: KUNDZNSXYFPGGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-氟苯氧基)-N,N-二甲基乙胺 、 1,10-二溴癸烷 以 丁酮 为溶剂， 生成
  参考文献：
  名称：

  Ratouis,R.; Boissier,J.R., Bulletin de la Societe Chimique de France, 1966, p. 3823 - 3825

  摘要：

  DOI：
• 作为产物：
  描述：

  sodium 4-fluorophenoxide 、 2-氯-N,N-二甲基乙胺 以 甲苯 为溶剂， 生成 2-(4-氟苯氧基)-N,N-二甲基乙胺
  参考文献：
  名称：

  Ratouis,R.; Boissier,J.R., Bulletin de la Societe Chimique de France, 1966, p. 3823 - 3825

  摘要：

  DOI：

文献信息

• 8-OXODIHYDROPURINE DERIVATIVE
  申请人：Aachi Keiji

  公开号：US20120172347A1

  公开（公告）日：2012-07-05

  The present invention provides a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof (wherein W represents a hydrogen atom, a halogen atom, or the others; A represents an alkyl group optionally substituted by aryl group or the others, an aryl group, or the others; and one of X and Y represents a di-substituted alkylaminocarbonyl group, or the others, and the other represents a hydrogen atom, an alkyl group, an alkylcarbonyl group, or the others); a medicament or a pharmaceutical composition for treatment or prophylaxis of FAAH-related diseases such as depression, anxiety disorder or pains, comprising the compound or the like as an active ingredient; a use of the compound or the like; and a method for treatment or prophylaxis using the compound or the like.

  本发明提供一种由式（1）表示的化合物或其药用可接受的盐（其中W代表氢原子、卤素原子或其他；A代表可选地被芳基取代的烷基基团或其他、芳基团或其他；X和Y中的一个代表二取代的烷基氨基羰基团或其他，另一个代表氢原子、烷基基团、烷基羰基团或其他）；一种治疗或预防FAAH相关疾病如抑郁症、焦虑症或疼痛的药物或药物组合物，包括该化合物或类似物作为活性成分；一种使用该化合物或类似物的用途；以及使用该化合物或类似物的治疗或预防方法。
• Disubstituted 1, 2, 4-triazine compound
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US10029993B2

  公开（公告）日：2018-07-24

  This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein RA is, for example, a group of the following formula (A-1): wherein ring A1 is, for example, a cycloalkyl group which may be substituted, and RB is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种新型二取代1,2,4-三嗪化合物或其药学上可接受的盐，该化合物具有醛固酮合成酶抑制活性，可用于预防和/或治疗与醛固酮相关的各种疾病或病症；本发明还提供了一种制备方法；本发明的用途；以及一种以本发明为活性成分的药物组合物。通式[I]的化合物： 其中 RA 是例如下式（A-1）的基团： 其中，环 A1 例如是可被取代的环烷基，RB 例如是单环环烷基、 或其药学上可接受的盐。
• NOVEL DISUBSTITUTED 1, 2, 4-TRIAZINE COMPOUND
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20170044115A1

  公开（公告）日：2017-02-16

  This invention provides a novel disubstituted 1,2,4-triazine compound or a pharmaceutically acceptable salt thereof, which has an aldosterone synthetase inhibitory activity and is useful for preventing and/or treating various diseases or conditions associated with aldosterone; a method for preparing it; use of it; as well as a pharmaceutical composition comprising it as an active ingredient. A compound of the general formula [I]: wherein R A is, for example, a group of the following formula (A-1): wherein ring A 1 is, for example, a cycloalkyl group which may be substituted, and R B is, for example, a monocyclic cycloalkyl group, or a pharmaceutically acceptable salt thereof.
• ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE CHROMATOGRAPHY RESIN
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：US20200406232A1

  公开（公告）日：2020-12-31

  Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatography. The chromatography resins allow for efficient purification of target biomolecules (e.g., recombinant proteins, antibodies, antibody-drug conjugates, or antibody derivatives including, but not limited to, antibody fragments and antibody fusions) from a sample, and have been found to be useful in purifying monomeric target biomolecules from aggregate target biomolecules. In an embodiment, the chromatography resins are useful for separating antibodies from one or more components (e.g., contaminants) in the sample.
• ANIONIC EXCHANGE-HYDROPHOBIC MIXED MODE CHROMATOGRAPHY RESINS
  申请人：BIO-RAD LABORATORIES, INC.

  公开号：US20210069692A1

  公开（公告）日：2021-03-11

  Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.