摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

(Rp)-(2-hydroxymethylphenyl)(methyl)(phenyl)phosphine-P-borane

中文名称
——
中文别名
——
英文名称
(Rp)-(2-hydroxymethylphenyl)(methyl)(phenyl)phosphine-P-borane
英文别名
(R)-(2-(methyl(phenyl)phosphino)phenyl)methanol borane;[[2-(hydroxymethyl)phenyl]-methyl-phenylphosphaniumyl]boranuide
CAS
——
化学式
C14H18BOP
mdl
——
分子量
244.081
InChiKey
GBCVYPBEBDEPFE-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    None
  • 重原子数:
    None
  • 可旋转键数:
    None
  • 环数:
    None
  • sp3杂化的碳原子比例:
    None
  • 拓扑面积:
    None
  • 氢给体数:
    None
  • 氢受体数:
    None

反应信息

  • 作为反应物:
    描述:
    (Rp)-(2-hydroxymethylphenyl)(methyl)(phenyl)phosphine-P-borane仲丁基锂氯化铵三乙胺 、 cesium fluoride 、 lithium bromide 作用下, 以 四氢呋喃二氯甲烷N,N-二甲基乙酰胺 为溶剂, 反应 11.5h, 生成 1-phenylbenzophospholane-borane
    参考文献:
    名称:
    Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished
    摘要:
    A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.
    DOI:
    10.1021/ol500970x
  • 作为产物:
    参考文献:
    名称:
    Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished
    摘要:
    A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.
    DOI:
    10.1021/ol500970x
点击查看最新优质反应信息

文献信息

  • Enzymatic kinetic resolution in the synthesis of new precursors of <i>P-</i>chiral organophosphorus catalysts: phosphines and their <i>P-</i>boranes
    作者:Lidia Madalińska、Piotr Kiełbasiński、Małgorzata Kwiatkowska
    DOI:10.1080/10426507.2021.2008929
    日期:2022.6.3
    on the solvent applied. The P-BH3 analogues were transformed into 2-aminomethyl derivatives via O-tosyl or O-mesyl intermediates, which will be checked as tridentate catalyst/ligands in asymmetric synthesis.
    摘要 外消旋 2-羟甲基苯基-(甲基)苯基膦及其P -BH 3类似物的 CAL-B 介导的动力学拆分通过它们的对映选择性单乙酰化反应产生了相应的单乙酸盐和未反应的底物,产率适中,对映体过量不确定,具体取决于应用溶剂。P -BH 3类似物通过邻甲苯磺酰基或邻甲磺酰基中间体转化为 2-氨基甲基衍生物,这将在不对称合成中作为三齿催化剂/配体进行检查。
  • Chiral Macrocyclic N<sub>2</sub>P<sub>2</sub> Ligands and Iron(II): A Marriage of Interest
    作者:Raphael Bigler、Elisabeth Otth、Antonio Mezzetti
    DOI:10.1021/om5005989
    日期:2014.8.11
    The N2P2 macrocyclic ligands (5S,8S,13E,14aS,18aS,19E)-5,8-diphenyl-5,6,7,8,14a,15,16,17,18,18a-decahydro-tribenzo[b,f,l][1,4,8,11]diazadiphosphacyclotetradecine ((1S,4S,9S,10S)-1a) and (5E,7R,8R,9E,15S,18S)-7,8,15,18-tetraphenyl-7,8, 15,16,17,18-hexahydrodibenzo[f, I] [1,4,8, 11 diazadiphosphacyclotetradecine ((1S,4S,9R,10R)-1b) were prepared by condensing the new, enantiomerically pure synthon 2,2'-((1S, 1'S)-ethane-1,2-diylbis(phenylphosphinediyl))dibenzaldehyde ((S,S)-8), prepared in six steps from (2R,4S,5R)3,4-dimethyl-2,5-diphenyl-1,3,2-oxazaphospholidine-2-borane (3)), with (1S,2S)-cyclohexane-1,2-diamine and (1R,2R)-1,2-diphenylethane-1,2-diamine under high-dilution conditions. The opposite enantiomers of the diamines gave oligomeric products. The stereospecificity of the macrocyclization reaction is explained by conformational analysis based on the X-ray structures of (1S,4S,9S,10S)-1a and (1S,4S,9R,10R)-1b. The corresponding diamino macrocycles (1S,4S,9S,10S)-2a and (1S,4S,9R,10R)-2b were prepared by reduction of the imine moiety of (1S,4S,9S,10S)-1a and (IS,45,9R,10R)-1b, respectively. Macrocycles (1S,4S,9S,10S)-1a, (1S,4S,9R,10R)-1b, and (IS,4S,9S,10S)-2a react with [Fe(OH2)(6)](BF4)(2) in acetonitrile to give the corresponding stable, diamagnetic bis(acetonitrile) complexes [Fe(MeCN)(2)(1)1(BF4)(2) (9a and 9b) and [Fe(MeCN)(2)(2a)](BF4)(2) (10a). Complex 9a exists as a 3:1 mixture of trans and Lambda-cis-beta isomers, whereas 9b and 10a adopt the Lambda-cis-beta configuration exclusively. The bis(acetonitrile) complexes are versatile precursors and were used to prepare the bromocarbonyl analogues [FeBr(CO)(1)]BPh4 (11a and 11b).
  • Efficient Asymmetric Syntheses of 1-Phenyl-phosphindane, Derivatives, and 2- or 3-Oxa Analogues: Mission Accomplished
    作者:Slavko Rast、Barbara Mohar、Michel Stephan
    DOI:10.1021/ol500970x
    日期:2014.5.16
    A highly enantioselective synthesis of unsubstituted 1-phenyl-phosphindane and its P-borane and P-oxide derivatives was effectively established via a new fluoride-triggered desilylative carbocyclization strategy. Preparation of the "oxygen atom-doped" 1-phenyl-3-oxa-1-phosphindane-P-borane analogue was otherwise achieved via a tandem P-alpha-iodination-intra-O-alkylation.
查看更多

同类化合物

(βS)-β-氨基-4-(4-羟基苯氧基)-3,5-二碘苯甲丙醇 (S)-(-)-7'-〔4(S)-(苄基)恶唑-2-基]-7-二(3,5-二-叔丁基苯基)膦基-2,2',3,3'-四氢-1,1-螺二氢茚 (S)-盐酸沙丁胺醇 (S)-3-(叔丁基)-4-(2,6-二甲氧基苯基)-2,3-二氢苯并[d][1,3]氧磷杂环戊二烯 (S)-2,2'-双[双(3,5-三氟甲基苯基)膦基]-4,4',6,6'-四甲氧基联苯 (S)-1-[3,5-双(三氟甲基)苯基]-3-[1-(二甲基氨基)-3-甲基丁烷-2-基]硫脲 (R)富马酸托特罗定 (R)-(-)-盐酸尼古地平 (R)-(+)-7-双(3,5-二叔丁基苯基)膦基7''-[((6-甲基吡啶-2-基甲基)氨基]-2,2'',3,3''-四氢-1,1''-螺双茚满 (R)-3-(叔丁基)-4-(2,6-二苯氧基苯基)-2,3-二氢苯并[d][1,3]氧杂磷杂环戊烯 (R)-2-[((二苯基膦基)甲基]吡咯烷 (N-(4-甲氧基苯基)-N-甲基-3-(1-哌啶基)丙-2-烯酰胺) (5-溴-2-羟基苯基)-4-氯苯甲酮 (5-溴-2-氯苯基)(4-羟基苯基)甲酮 (5-氧代-3-苯基-2,5-二氢-1,2,3,4-oxatriazol-3-鎓) (4S,5R)-4-甲基-5-苯基-1,2,3-氧代噻唑烷-2,2-二氧化物-3-羧酸叔丁酯 (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮 (4-丁氧基苯甲基)三苯基溴化磷 (3aR,8aR)-(-)-4,4,8,8-四(3,5-二甲基苯基)四氢-2,2-二甲基-6-苯基-1,3-二氧戊环[4,5-e]二恶唑磷 (2Z)-3-[[(4-氯苯基)氨基]-2-氰基丙烯酸乙酯 (2S,3S,5S)-5-(叔丁氧基甲酰氨基)-2-(N-5-噻唑基-甲氧羰基)氨基-1,6-二苯基-3-羟基己烷 (2S,2''S,3S,3''S)-3,3''-二叔丁基-4,4''-双(2,6-二甲氧基苯基)-2,2'',3,3''-四氢-2,2''-联苯并[d][1,3]氧杂磷杂戊环 (2S)-(-)-2-{[[[[3,5-双(氟代甲基)苯基]氨基]硫代甲基]氨基}-N-(二苯基甲基)-N,3,3-三甲基丁酰胺 (2S)-2-[[[[[[((1R,2R)-2-氨基环己基]氨基]硫代甲基]氨基]-N-(二苯甲基)-N,3,3-三甲基丁酰胺 (2-硝基苯基)磷酸三酰胺 (2,6-二氯苯基)乙酰氯 (2,3-二甲氧基-5-甲基苯基)硼酸 (1S,2S,3S,5S)-5-叠氮基-3-(苯基甲氧基)-2-[(苯基甲氧基)甲基]环戊醇 (1-(4-氟苯基)环丙基)甲胺盐酸盐 (1-(3-溴苯基)环丁基)甲胺盐酸盐 (1-(2-氯苯基)环丁基)甲胺盐酸盐 (1-(2-氟苯基)环丙基)甲胺盐酸盐 (-)-去甲基西布曲明 龙胆酸钠 龙胆酸叔丁酯 龙胆酸 龙胆紫 龙胆紫 齐达帕胺 齐诺康唑 齐洛呋胺 齐墩果-12-烯[2,3-c][1,2,5]恶二唑-28-酸苯甲酯 齐培丙醇 齐咪苯 齐仑太尔 黑染料 黄酮,5-氨基-6-羟基-(5CI) 黄酮,6-氨基-3-羟基-(6CI) 黄蜡,合成物 黄草灵钾盐