2-methylglutaramide | 14167-89-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methylglutaramide
• 英文别名: 2-methylpentanediamide
• CAS: 14167-89-6
• 化学式: C₆H₁₂N₂O₂
• mdl: MFCD19206524
• 分子量: 144.173
• InChiKey: MFXUHBWEUJSJAU-UHFFFAOYSA-N

物化性质

• 熔点：
  89-90 °C
• 沸点：
  449.3±28.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-甲基环戊烷-1,2-二胺 在 乙酰胺 、 溶剂黄146 、 tetrakis(acetonitrile)palladium(II) tetrafluoroborate 作用下， 50.0 ℃ 、399.97 Pa 条件下， 反应 2.5h， 以63%的产率得到2-methylglutaramide
  参考文献：
  名称：

  二腈的水合转移到二甲酰胺

  摘要：

  我们提出了一种可靠的二腈双转移水合方法，以提供二酰胺。在以乙酰胺为水供体的钯（II）催化剂存在下，1,n-二腈（n = 1-6）的转移水合顺利进行，以中等至高产率提供相应的二酰胺，且不涉及显着的副反应如一水合或环化。通过在减压下去除联产乙腈，平衡向前移动。

  DOI：

  10.1055/s-0039-1690026

文献信息

• Enzymatic nitrile hydrolysis catalyzed by nitrilase ZmNIT2 from maize. An unprecedented β-hydroxy functionality enhanced amide formation
  作者：Chandrani Mukherjee、Dunming Zhu、Edward R. Biehl、Rajiv R. Parmar、Ling Hua

  DOI：10.1016/j.tet.2006.04.069

  日期：2006.6

  To explore the synthetic potential of nitrilase ZmNIT2 from maize, the substrate specificity of this nitrilase was studied with a diverse collection of nitriles. The nitrilase ZmNIT2 showed high activity for all the tested nitriles except benzonitrile, producing both acids and amides. For the hydrolysis of aliphatic, aromatic nitriles, phenylacetonitrile derivatives and dinitriles, carboxylic acids

  为了探索玉米中腈水解酶ZmNIT2的合成潜力，研究了该腈水解酶的底物特异性，并收集了多种腈。腈水解酶ZmNIT2对除苄腈以外的所有测试腈均显示高活性，同时生成酸和酰胺。对于脂族，芳族腈，苯乙腈衍生物和二腈的水解，羧酸是主要产物。出乎意料的是，发现酰胺是腈水解酶ZmNIT2催化的β-羟基腈水解的主要产物。酶-底物复杂中间体中羟基和氮之间的氢键不利于氨的损失和酰基-酶中间体的形成，后者进一步水解为酸，
• HYDROGENATION CATALYSTS, THE PRODUCTION AND THE USE THEREOF
  申请人：Wigbers Christof Wilhelm

  公开号：US20110313186A1

  公开（公告）日：2011-12-22

  The present invention relates to catalysts and processes for preparation thereof, said catalysts being obtainable by contacting a monolithic catalyst support with a suspension which comprises one or more insoluble or sparingly soluble compounds of the elements selected from the group of the elements cobalt, nickel and copper. The invention further relates to the use of the inventive catalyst in a process for hydrogenating organic substances, especially for hydrogenating nitriles, and to a process for hydrogenating organic compounds, which comprises using an inventive catalyst in the process.

  本发明涉及催化剂和其制备方法，所述催化剂可通过将单体催化剂载体与包含来自元素钴、镍和铜组的元素中的一种或多种不溶或难溶化合物的悬浮液接触而获得。本发明还涉及在氢化有机物质的过程中使用这种创新催化剂，特别是用于氢化腈的过程，并涉及一种氢化有机化合物的过程，其中在过程中使用了一种创新催化剂。
• METHOD FOR IMPROVING THE CATALYTIC ACTIVITY OF MONOLITHIC CATALYSTS
  申请人：Wigbers Christof Wilhelm

  公开号：US20110313187A1

  公开（公告）日：2011-12-22

  The present invention relates to a process for improving the catalytic properties of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The invention further relates to a process for hydrogenating compounds which comprise at least one unsaturated carbon-carbon, carbon-nitrogen or carbon-oxygen bond in the presence of a catalyst comprising one or more elements selected from the group consisting of cobalt, nickel and copper, said catalyst being present in the form of a structured monolith, by contacting the catalyst with one or more basic compounds selected from the group of the alkali metals, alkaline earth metals and rare earth metals. The present invention also relates to the use of a basic compound selected from the group of the alkali metals, alkaline earth metals and rare earth metals for improving the catalytic properties of a catalyst comprising cobalt and/or copper and/or nickel, said catalyst being present in the form of a structured monolith.

  本发明涉及一种改善催化剂性能的过程，所述催化剂包括从钴、镍和铜组成的元素中选择的一个或多个元素，所述催化剂呈现为结构化单体，并通过将催化剂与从碱金属、碱土金属和稀土金属组中选择的一个或多个碱性化合物接触来实现。本发明还涉及一种在存在从钴、镍和铜组成的元素中选择的一个或多个元素的催化剂的情况下，通过将催化剂与从碱金属、碱土金属和稀土金属组中选择的一个或多个碱性化合物接触来氢化包含至少一个不饱和碳-碳、碳-氮或碳-氧键的化合物的过程。本发明还涉及使用从碱金属、碱土金属和稀土金属组中选择的碱性化合物来改善包括钴和/或铜和/或镍的催化剂的催化性能的用途，所述催化剂呈现为结构化单体。
• HYALURONIC ACID DERIVATIVE HAVING AMINO ACID AND STERYL GROUP INTRODUCED THEREINTO
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：US20150231268A1

  公开（公告）日：2015-08-20

  The present invention provides a hyaluronic acid derivative containing a disaccharide unit represented by formula (I) or formula (I) and (II), and a complex containing the hyaluronic acid derivative and a drug.

  本发明提供了一种含有由化学式（I）或化学式（I）和（II）表示的二糖单元的透明质酸衍生物，以及含有该透明质酸衍生物和药物的复合物。
• Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
  申请人：Bramucci G. Michael

  公开号：US20060115883A1

  公开（公告）日：2006-06-01

  A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either a nitrilase activity or a combination of nitrile hydratase and amidase activities. The method provides high yields without significant conversion of (Z)-2M2BN to (Z)-2M2BA. The regioselective hydrolysis of (E)-2M2BN to (E)-2M2BA makes possible the facile separation of (E)-2M2BA from (Z)-2M2BN or (Z)-2-methyl-2-butenamide (2M2BAm), and the subsequent conversion of (Z)-2M2BN or (Z)-2M2BAm to (Z)-2M2BA.

  一种方法已经开发出来，可以通过(E)-和(Z)-2-甲基-2-丁烯酸（2M2BA）的选择性水解，从(E,Z)-2-甲基-2-丁烯腈（2M2BN）混合物中制备出来。该方法使用具有腈酶活性或腈水化酶和酰胺酶活性组合的酶催化剂，提供高产率，而不显著转化(Z)-2M2BN为(Z)-2M2BA。将(E)-2M2BN选择性水解为(E)-2M2BA，使得可以轻松地将(E)-2M2BA与(Z)-2M2BN或(Z)-2-甲基-2-丁烯酰胺（2M2BAm）分离，并将(Z)-2M2BN或(Z)-2M2BAm转化为(Z)-2M2BA。