(2S,4S)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)-2-(4-nitrobenzyloxycarbonyl)oxymethylpyrrolidine | 352307-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)-2-(4-nitrobenzyloxycarbonyl)oxymethylpyrrolidine
• 英文别名: (4-nitrophenyl)methyl (2S,4S)-4-hydroxy-2-[(4-nitrophenyl)methoxycarbonyloxymethyl]pyrrolidine-1-carboxylate
• CAS: 352307-13-2
• 化学式: C₂₁H₂₁N₃O₁₀
• 分子量: 475.412
• InChiKey: HFDXDJUJQRQOAA-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  177
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,6-二甲基吡啶 、 (2S,4S)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)-2-(4-nitrobenzyloxycarbonyl)oxymethylpyrrolidine 、 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(7-methylthioimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate 生成 4-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxy-ethyl)-1-methyl-2-[7-methylthio-6-[(3R,5S)-1-(4-nitro-benzyloxycarbonyl)-5-(4-nitrobenzyloxycarbonyl)oxy-methylpyrrolidin-3-yl]imidazo[5,1-b]-tiazolium-2-yl]-1-carbapen-2-em3-carboxylate chloride 、 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[7-methylthio-6-[(3R,5S)-1-(4-nitrobenzyloxycarbonyl)-5-(4-nitrobenzyloxy-carbonyl)oxymethylpyrrolidin-3-yl]imidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate chloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Novel carbapenem derivatives of quarternary salt type
  申请人：——

  公开号：US20030022881A1

  公开（公告）日：2003-01-30

  An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: 1 wherein R 1 represents H or methyl; R 2 and R 3 each independently represent H, halogen, lower alkyl or the like; R 4 represents optionally substituted lower alkylthio or the like; and R 5 represents optionally substituted lower alkyl or the like.

  本发明的目的在于提供对MRSA、PRSP、流感病毒和β-内酰胺酶产生菌具有强大抗生素活性的碳青霉烯衍生物，且对DHP-1稳定。根据本发明的化合物是由公式(I)表示的化合物或其药物可接受的盐：1其中R1代表H或甲基；R2和R3各自独立地代表H、卤素、低级烷基等；R4代表可选地取代的低级烷基亚磺酰基等；R5代表可选地取代的低级烷基等。
• NOVEL CARBAPENEM DERIVATIVES OF QUATERNARY SALT TYPE
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1251134A1

  公开（公告）日：2002-10-23

  An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and β-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: wherein R1 represents H or methyl; R2 and R3 each independently represent H, halogen, lower alkyl or the like; R4 represents optionally substituted lower alkylthio or the like; and R5 represents optionally substituted lower alkyl or the like.

  本发明的目的是提供碳青霉烯类衍生物，它们对 MRSA、PRSP、流感病毒和产 β-内酰胺酶细菌具有强效抗生素活性，并且对 DHP-1 稳定。根据本发明的化合物是由式（I）代表的化合物或其药学上可接受的盐： 其中 R1 代表 H 或甲基；R2 和 R3 各自独立地代表 H、卤素、低级烷基或类似物；R4 代表任选取代的低级烷硫基或类似物；R5 代表任选取代的低级烷基或类似物。
• US6825187B2
  申请人：——

  公开号：US6825187B2

  公开（公告）日：2004-11-30