2,6-dimethyl-3,5-dichloropyridine | 74120-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-dimethyl-3,5-dichloropyridine
• 英文别名: 3,5-dichloro-2,6-dimethylpyridine
• CAS: 74120-78-8
• 化学式: C₇H₇Cl₂N
• 分子量: 176.045
• InChiKey: VUARCKRMSQVGQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,6-二甲基吡啶 在 氯 、 sodium carbonate 作用下， 以 四氯化碳 、 水 为溶剂， 反应 6.0h， 以60%的产率得到2,6-dimethyl-3,5-dichloropyridine
  参考文献：
  名称：

  2，6-二甲基吡啶中的氢被锂或卤素取代的顺序

  摘要：

  DOI：

  10.1007/bf00475401

文献信息

• [EN] QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS<br/>[FR] COMPOSÉ DE QUINUCLIDINE COMME LIGANDS DU RÉCEPTEUR NICOTINIQUE ALPHA-7 DE L'ACÉTYLCHOLINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011053292A1

  公开（公告）日：2011-05-05

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  该披露提供了公式I的化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是烟碱7受体的配体，可能对治疗中枢神经系统的各种紊乱，特别是情感和神经退行性疾病有用。
• Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands
  申请人：Bristol-Myers Squibb Company

  公开号：US20130131064A1

  公开（公告）日：2013-05-23

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  本披露提供了I式化合物及其盐，以及使用这些化合物的组合物和方法。这些化合物是尼古丁α7受体的配体，可能有助于治疗中枢神经系统的各种疾病，尤其是情感和神经退行性疾病。
• QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150342935A1

  公开（公告）日：2015-12-03

  The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

  该披露提供了I式化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物是尼古丁α7受体的配体，可能对中枢神经系统的各种障碍，尤其是情感和神经退行性障碍的治疗有用。
• Process for producing ethylidene diacetate and/or acetaldehyde
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0035860A2

  公开（公告）日：1981-09-16

  A process for producing ethylidene diacetate and/or acetaldehyde which comprises causing hydrocarbonylation reaction of methyl acetate or dimethyl ether with carbon monoxide and hydrogen in the presence of a catalyst consisting essentially of (i) as a main component palladium supported on a porous inorganic material and (ii) as a secondary component at least one halide selected from the group consisting of iodides, bromides and mixtures thereof under substantially anhydrous condition is disclosed.

  本发明公开了一种生产二乙酸亚乙酯和/或乙醛的工艺，该工艺包括在催化剂存在的情况下，使乙酸甲酯或二甲醚与一氧化碳和氢发生烃化反应，催化剂主要包括：(i)作为主要成分的支撑在多孔无机材料上的钯，和(ii)作为辅助成分的至少一种选自碘化物、溴化物及其混合物组成的组的卤化物。
• Process for producing acetic anhydride
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0055622A1

  公开（公告）日：1982-07-07

  A process for producing acetic anhydride which comprises reacting methyl acetate or dimethyl ether with carbon monoxide in the presence of a catalyst comprising (a) nickel or a nickel compound, (b) at least one halide selected from the group consisting of bromides, iodides and mixtures thereof and (c) at least one organic nitrogen group compound and together with a specific co-catalyst is disclosed. According to this invention acetic anhydride is produces by using highly active non-expensive catalyst and co-catalyst.

  本发明公开了一种生产醋酸酐的工艺，该工艺包括在催化剂存在下使醋酸甲酯或二甲醚与一氧化碳反应，催化剂包括(a)镍或镍化合物，(b)至少一种从溴化物、碘化物及其混合物组成的组中选出的卤化物和(c)至少一种有机氮基团化合物，以及特定的助催化剂。根据本发明，使用高活性非昂贵催化剂和助催化剂可生产醋酸酐。