2,6-dibenzylidene-3-methyl-cyclohexanone | 42019-89-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2,6-dibenzylidene-3-methyl-cyclohexanone
• 英文别名: 2,6-Dibenzyliden-3-methyl-cyclohexanon；2,6-bis(phenylmethylene) (3-methylcyclohexanone)；2,6-bis(phenylmethylene)(3-methylcyclohexanone)；2,6-Bisbenzyliden-3-methylcyclohexanon；2,6-Dibenzylidene-3-methylcyclohexan-1-one
• CAS: 42019-89-6
• 化学式: C₂₁H₂₀O
• 分子量: 288.389
• InChiKey: CLIGIHASZVYIMB-UHFFFAOYSA-N

物化性质

• 熔点：
  115 °C
• 沸点：
  472.4±45.0 °C(Predicted)
• 密度：
  1.115±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-dibenzylidene-3-methyl-cyclohexanone 在 乙醇 、 sodium 作用下， 生成 2,6-Dibenzyl-3-methyl-cyclohexanol
  参考文献：
  名称：

  Haller; March, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905, vol. 140, p. 625

  摘要：

  DOI：
• 作为产物：
  描述：

  苯甲醛 、 3-甲基环己酮 在 sodium hydroxide 作用下， 生成 2,6-dibenzylidene-3-methyl-cyclohexanone
  参考文献：
  名称：

  取代的Hydrindanes的合成。第一部分. 由丙酮基环己酮和丙酮基环己二酮环化产生的产物

  摘要：

  某些 1,4-二酮的制备和环化已被研究作为取代 hydrindan-2-one 系统的途径。还描述了遇到的其他类型的产品。

  DOI：

  10.1139/v75-209

文献信息

• Serum Carnitine Levels During Oxcarbazepine and Carbamazepine Monotherapies in Children With Epilepsy
  作者：Semra Kurul、Eray Dirik、Akin Iİscan

  DOI：10.1177/08830738030180080201

  日期：2003.8

  Prolonged antiepilepsy drug treatment can result in secondary carnitine deficiency. The effect of oxcarbazepine on carnitine metabolism has not been reported previously. In this study, serum concentrations of total and free carnitine were measured in 20 children with epilepsy treated with oxcarbazepine monotherapy and were compared with 20 children with epilepsy who were taking carbamazepine as monotherapy. The assays were performed between 3 and 6 months of anticonvulsant treatment. The mean values of serum total and free carnitine levels in patients receiving carbamazepine monotherapy were 63.0 ± 20.7 μmol/L and 49.1 ± 16.7 μmol/L, respectively. The mean values of serum total and free carnitine levels in patients receiving oxcarbazepine monotherapy were 64.2 ± 17.4 μmol/L and 50.3 ± 13.7 μmol/L, respectively. The values were all between normal ranges. No significant difference was observed in the level of total and free carnitine levels between the two groups. Our results suggest that neither oxcarbazepine nor carbamazepine as monotherapy causes carnitine deficiency in otherwise healthy children with primary idiopathic epilepsy. ( J Child Neurol 2003;18:552—554).

  长期抗癫痫药物治疗可能导致继发性肉碱缺乏。奥卡西平对肉碱代谢的影响尚未有报道。在这项研究中，测量了20名接受奥卡西平单药治疗的癫痫患儿的血清总肉碱和游离肉碱浓度，并与20名接受卡马西平单药治疗的癫痫患儿进行了比较。检测是在抗惊厥治疗3至6个月之间进行的。接受卡马西平单药治疗的患者血清总肉碱和游离肉碱水平的平均值分别为63.0 ± 20.7 μmol/L和49.1 ± 16.7 μmol/L。接受奥卡西平单药治疗的患者血清总肉碱和游离肉碱水平的平均值分别为64.2 ± 17.4 μmol/L和50.3 ± 13.7 μmol/L。所有数值均在正常范围内。两组之间的总肉碱和游离肉碱水平没有显著差异。我们的结果表明，奥卡西平或卡马西平作为单药治疗在否则健康的原发性特发性癫痫患儿中不会导致肉碱缺乏。【《儿童神经病学杂志》2003年；18：552—554】
• Cornubert; Humeau, Bulletin de la Societe Chimique de France, 1931, vol. <4> 49, p. 1468,1483
  作者：Cornubert、Humeau

  DOI：——

  日期：——
• Einhorn; Ehret, Justus Liebigs Annalen der Chemie, 1897, vol. 295, p. 175
  作者：Einhorn、Ehret

  DOI：——

  日期：——
• Wallach, Chemische Berichte, 1896, vol. 29, p. 1601
  作者：Wallach

  DOI：——

  日期：——
• Kohler, American Chemical Journal, 1907, vol. 37, p. 381
  作者：Kohler

  DOI：——

  日期：——