3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine | 458543-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine
• 英文别名: 3-Chloro-2-(3-chloro-pyrazol-1-YL)-pyridine；3-chloro-2-(3-chloropyrazol-1-yl)pyridine
• CAS: 458543-78-7
• 化学式: C₈H₅Cl₂N₃
• 分子量: 214.054
• InChiKey: FOTJIYSUKUPALY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine 在 甲基磺酰氯 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 3.67h， 生成 6-chloro-2-[3-chloro-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-8-methyl-4H-3,1-benzoxazin-4-one
  参考文献：
  名称：

  Anthranilamide arthropodicide treatment

  摘要：

  这项发明涉及一种保护繁殖体或从中生长的植物免受无脊椎动物害虫侵害的方法，包括将繁殖体或繁殖体的位置与化合物I的生物有效量，其N-氧化物或农业适用盐之一接触，其中A和B以及R1至R8如披露中所定义。该发明还涉及用化合物I处理过的繁殖体和包含化合物I的配方用于包覆繁殖体。

  公开号：

  US09173400B2
• 作为产物：
  描述：

  2,3-二氯吡啶 、 3-氯-1H-吡唑 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 36.0h， 生成 3-chloro-2-(3-chloro-1H-pyrazol-1-yl)pyridine
  参考文献：
  名称：

  [EN] CYANO ANTHRANILAMIDE INSECTICIDES
  [FR] INSECTICIDES A BASE DE CYANO-ANTHRANILAMIDE

  摘要：

  这项发明提供了Formula (I)的化合物，N-氧化物及其适当的盐插入Formula I的公式如下：其中R1为Me、Cl、Br或F；R2为F、Cl、Br、C1-C4卤代烷基或C1-C4卤代烷氧基；R3为F、Cl或Br；R4为H或C1-C4烷基、C3-C4烯基、C3-C4炔基、C3-C5环烷基或C4-C6环烷烷基，每个均可选择一个来自卤素、CN、SMe、S(O)Me、S(O)2Me和OMe的取代基；R5为H或Me；R6为H、F或Cl；R7为H、F或Cl。还公开了一种用于控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与Formula (I)的化合物、其N-氧化物或化合物的适当盐（例如，作为本文所述的组合物）的生物有效量接触。这项发明还涉及一种用于控制无脊椎动物害虫的组合物，包括Formula (I)的化合物、其N-氧化物或化合物的适当盐的生物有效量，以及从表面活性剂、固体稀释剂和液体稀释剂中选择的至少一种额外成分。

  公开号：

  WO2004067528A1

文献信息

• Method of controlling particular insect pests by applying anthranilamide compounds
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US09113630B2

  公开（公告）日：2015-08-25

  This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a benzoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.

  这项发明涉及一种控制鳞翅目、同翅目、半翅目、鳞翅目和鞘翅目昆虫害虫的方法，包括将昆虫或其环境与化合物I的有效量，其N-氧化物或农业适用的盐接触，其中A和B以及R1至R8如披露中定义。该发明还涉及化合物10的苯并噁唑酮化合物，其中R4至R8如披露中定义，用于制备化合物I。
• Arthropodicidal anthranilamides
  申请人：——

  公开号：US20040198984A1

  公开（公告）日：2004-10-07

  This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts 1 wherein R 1 , R 2 , R 3 , R 4a , R 4b and R 5 are as defined in the disclosure. Also disclosed are methods for controlling invertebrate pests comprising contacting the invertebrate pests or their environment with a biologically effective amount of a compound of Formula 1 or a composition comprising a compound of Formula 1.

  本发明提供了一些式子为1的化合物，它们的N-氧化物和适用于农业的盐，其中R1、R2、R3、R4a、R4b和R5如披露中所定义。还披露了一种控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或它们的环境与式1的化合物或包含式1的化合物的组合物接触，以生物学有效量。
• Cyano anthranilamide insecticides
  申请人：Hughes Andrew Kenneth

  公开号：US20060111403A1

  公开（公告）日：2006-05-25

  This invention provides compounds of Formula (I), N-oxides and suitable salts thereof INSERT FORMULA I HERE wherein R 1 is Me, Cl, Br or F; R 2 is F, Cl, Br, C 1 -C 4 haloalkyl or C 1 -C 4 haloalkoxy; R 3 is F, Cl or Br; R 4 is H or C 1 -C 4 alkyl, C 3 -C 4 alkenyl, C 3 -C 4 alkynyl, C 3 -C 5 cycloalkyl, or C 4 -C 6 cycloalkylalkyl, each optionally substituted with one substituent selected from the group consisting of halogen, CN, SMe S(O)Me, S(O) 2 Me and OMe; R 5 is H or Me; R 6 is H, F or Cl; and R 7 is H, F or Cl. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of a surfactant, a solid diluent and a liquid diluent.

  本发明提供了公式（I）的化合物，N-氧化物和适当的盐INSERT FORMULA I HERE，其中R1为Me，Cl，Br或F；R2为F，Cl，Br，C1-C4卤代烷基或C1-C4卤代甲氧基；R3为F，Cl或Br；R4为H或C1-C4烷基，C3-C4烯基，C3-C4炔基，C3-C5环烷基或C4-C6环烷基烷基，每个可选择地被一个取代基所取代，所述取代基选自卤素，CN，SMe，S（O）Me，S（O）2Me和OMe的群；R5为H或Me；R6为H，F或Cl；R7为H，F或Cl。本发明还揭示了一种控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与公式（I）的化合物，其N-氧化物或化合物的适当盐的生物学有效量接触（例如，作为本文所述的组分的组合物）。本发明还涉及一种用于控制无脊椎动物害虫的组合物，包括公式（I）的化合物，其N-氧化物或化合物的适当盐的生物学有效量和至少一种来自表面活性剂，固体稀释剂和液体稀释剂的组分。
• Heterocyclic diamide invertebrate pest control agents
  申请人：——

  公开号：US20040102324A1

  公开（公告）日：2004-05-27

  This invention provides compounds of Formula (I), N-oxides and suitable salts thereof, wherein A and B are independently O or S; each J is independently a phenyl ring, a naphthyl ring system, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system wherein each ring or ring system is optionally substituted with 1 to 4 R 5 ; K is, together with the two contiguous linking carbon atoms, a 5- or 6-membered heteroaromatic ring optionally substituted with 1 to 3 R 4 ; and R 1 , R 2 , R 3 , R 4 , R 5 and n are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula (I), an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. 1

  本发明提供了式（I）的化合物、N-氧化物及其适当的盐，其中A和B分别为O或S;每个J分别为苯环、萘环系统、5-或6-成员杂环芳香环或芳香8、9或10-成员融合杂双环系统，其中每个环或环系统可选地被1到4个R5取代；K与两个相邻的连接碳原子一起，是一个5-或6-成员杂环芳香环，可选地被1到3个R4取代；以及R1、R2、R3、R4、R5和n如本公开说明中所定义的。还公开了用式（I）的化合物、其N-氧化物或化合物的适当盐（例如，如本文所述的组成物）的生物有效量接触无脊椎动物害虫或其环境的方法。本发明还涉及一种用于控制无脊椎动物害虫的组合物，包括式（I）的化合物、其N-氧化物或化合物的适当盐的生物有效量，以及至少一种来自表面活性剂、固体稀释剂和液体稀释剂的组分。
• Method for preparing fused oxazinones from ortho-amino aromatic carboxylic acid and carboxylic acid in the presence of a sulfonyl chloride and pyridine
  申请人：Taylor Deguyon Eric

  公开号：US20050215785A1

  公开（公告）日：2005-09-29

  A method for preparing a fused oxazinone is disclosed in which (1) a carboxylic acid is contacted with a sulfonyl chloride in the presence of an optionally substituted pyridine compound, the nominal mole ratio of sulfonyl chloride to carboxylic acid being from about 0.75 to 1.5; (2) the mixture prepared in (1) is contacted with an ortho-amino aromatic carboxylic acid in the presence of an optionally substituted pyridine compound, the nominal mole ratio of the ortho-amino aromatic carboxylic acid to carboxylic acid charged in (1) being from about 0.8 to 1.2; and (3) additional sulfonyl chloride is added to the mixture prepared in (2), the nominal mole ratio of additional sulfonyl chloride added in (3) to carboxylic acid charged in (1) being at least about 0.5. Also disclosed is a method for preparing a compound of Formula III, using a compound of Formula 1a that is characterized by preparing the fused oxazinone of Formula 1a by the method above, using a compound of the formula LS(O) 2 Cl as the sulfonyl chloride, a compound of Formula 2′ as the carboxylic acid, and a compound of Formula 5′ as the ortho-amino aromatic carboxylic acid (FORMULA la) (FORMULA III) (FORMULA 2′) (FORMULA 5′) wherein L, X, Y and R 1 through R 9 are as defined in the disclosure.

  本发明公开了一种制备融合噁唑酮的方法，其中（1）在可选取代的吡啶化合物存在下，将羧酸与磺酰氯接触，磺酰氯与羧酸的名义摩尔比约为0.75至1.5；（2）在可选取代的吡啶化合物存在下，将（1）中制备的混合物与一种邻氨基芳香羧酸接触，邻氨基芳香羧酸与（1）中充电的羧酸的名义摩尔比约为0.8至1.2；（3）向（2）中制备的混合物中添加额外的磺酰氯，添加到（1）中充电的羧酸的名义摩尔比至少为0.5。本发明还公开了一种制备III式化合物的方法，使用式1a的化合物，其特征在于通过上述方法制备式1a的融合噁唑酮，使用式LS（O）2Cl作为磺酰氯，使用式2′的化合物作为羧酸，使用式5′的化合物作为邻氨基芳香羧酸（式la）（式III）（式2′）（式5′），其中L、X、Y和R1至R9如本公开文献所定义。