2,3-bis[(E)-2-phenylethenyl]pyridine | 1255651-65-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-bis[(E)-2-phenylethenyl]pyridine
• 英文别名: Distyrylpyridine
• CAS: 1255651-65-0
• 化学式: C₂₁H₁₇N
• 分子量: 283.373
• InChiKey: PFNQMRMIBIQLDI-WXUKJITCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙烯 、 2,3-二氯吡啶 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以11%的产率得到2,3-bis[(E)-2-phenylethenyl]pyridine
  参考文献：
  名称：

  二溴吡啶的双颈交叉偶联反应

  摘要：

  2,3和3,5-二溴吡啶与各种烯烃的双Heck交叉偶联反应提供了相应的新型二（烯基）吡啶。2,5-二溴吡啶的Heck反应出乎意料地通过钯催化的二聚作用得到5,5'-二（烯基）-2,2'-联吡啶，得到5,5'-二溴-2,2'-联吡啶和随后的两倍哎呀反应。

  DOI：

  10.1002/hlca.201000108

文献信息

• BIS(STYRYL)PYRIMIDINE OR BIS(STYRYL)BENZENE COMPOUNDS, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES FEATURING AMYLOIDS COMPRISING THE SAME AS AN ACTIVE INGREDIENT
  申请人：SHIN Kye Jung

  公开号：US20100190803A1

  公开（公告）日：2010-07-29

  Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases. (wherein R 1 , R 2 , R 3 and X are as defined in the specification)

  本发明涉及一种由化学式1表示的双(苯乙烯基)嘧啶或双(苯乙烯基)苯化合物，其药学上可接受的盐，其制备方法以及一种药物组合物，用于预防和治疗与淀粉样蛋白病相关的疾病，其中该化合物为活性成分。该衍生物具有抑制β淀粉样蛋白沉积和减少其毒性的能力，可以改善学习和记忆，并且可以在预防和治疗与淀粉样蛋白病相关的疾病方面有用。（其中R1、R2、R3和X如规范中所定义）
• PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, CURED PRODUCT, SEMICONDUCTOR DEVICE, METHOD FOR FORMING RESIST PATTERN, AND METHOD FOR PRODUCING CIRCUIT SUBSTRATE
  申请人：Hitachi Chemical Company, Ltd.

  公开号：US20170329220A1

  公开（公告）日：2017-11-16

  A photosensitive resin composition comprises: a resin having a phenolic hydroxyl group; a photosensitive acid generator; a compound having at least one selected from the group consisting of an aromatic ring, a heterocycle and an alicycle, and at least one selected from the group consisting of a methylol group and an alkoxyalkyl group; an aliphatic compound having two or more functional groups being at least one selected from the group consisting of an acryloyloxy group, a methacryloyloxy group, a glycidyloxy group, an oxetanyl alkyl ether group, a vinyl ether group and a hydroxyl group; and a compound having at least one skeleton selected from the group consisting of an anthracene skeleton, a phenanthrene skeleton, a pyrene skeleton, a perylene skeleton, a carbazole skeleton, a phenothiazine skeleton, a xanthone skeleton, a thioxanthone skeleton, an acridine skeleton, a phenylpyrazoline skeleton, a distyrylbenzene skeleton and a distyrylpyridine skeleton, or a benzophenone compound.
• US4680407A
  申请人：——

  公开号：US4680407A

  公开（公告）日：1987-07-14
• US8410116B2
  申请人：——

  公开号：US8410116B2

  公开（公告）日：2013-04-02
• Double Heck Cross-Coupling Reactions of Dibrominated Pyridines
  作者：Asad Ali、Munawar Hussain、Imran Malik、Alexander Villinger、Christine Fischer、Peter Langer

  DOI：10.1002/hlca.201000108

  日期：——

  Double Heck cross‐coupling reactions of 2,3‐ and 3,5‐dibromopyridine with various alkenes afforded the corresponding novel di(alkenyl)pyridines. The Heck reaction of 2,5‐dibromopyridine unexpectedly afforded 5,5′‐di(alkenyl)‐2,2′‐bipyridines by palladium‐catalyzed dimerization to give 5,5′‐dibromo‐2,2′‐bipyridine and subsequent twofold Heck reaction.

  2,3和3,5-二溴吡啶与各种烯烃的双Heck交叉偶联反应提供了相应的新型二（烯基）吡啶。2,5-二溴吡啶的Heck反应出乎意料地通过钯催化的二聚作用得到5,5'-二（烯基）-2,2'-联吡啶，得到5,5'-二溴-2,2'-联吡啶和随后的两倍哎呀反应。