4-(2-ethoxyvinyl)nitrobenzene | 32427-47-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-ethoxyvinyl)nitrobenzene
• 英文别名: 1-Aethoxy-2-p-nitrophenylaethylen；1-[(E)-2-ethoxyethenyl]-4-nitrobenzene
• CAS: 32427-47-7
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.202
• InChiKey: IOSGSBNWAJVSSN-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-ethoxyvinyl)nitrobenzene 在 溴 、 碳酸氢钠 作用下， 以 乙醚 、 水 为溶剂， 生成 2-bromo-2-(4-nitrophenyl)acetaldehyde
  参考文献：
  名称：

  2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles

  摘要：

  这项发明涉及对溃疡的治疗和预防有用的2-[(咪唑[1,2-a]吡啶基甲基)-亚砜基]-1H-苯并咪唑。

  公开号：

  US04687775A1
• 作为产物：
  描述：

  乙烯基乙醚 、 1-溴-4-硝基苯 在 bis-<(4-Cl-2-PdCl-Ph)-(4-Cl-Ph)-methanone oxime> 四丁基溴化铵 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 4,4-二硝基二苯醚 、 4-(2-ethoxyvinyl)nitrobenzene 、 (Z)-1-(2-ethoxyethenyl)-4-nitrobenzene
  参考文献：
  名称：

  Oxime-Derived Palladium Complexes as Very Efficient Catalysts for the Heck–Mizoroki Reaction

  摘要：

  Oxime-derived, chloro-bridged palladacycles 16 are efficient complexes for the Heck vinylation of aryl halides. The isolated catalysts are thermally stable, not sensitive to air or moisture and easily accessible from inexpensive starting materials. The reaction can be performed under aerobic conditions, with aryl iodides, bromides and chlorides with acrylic esters and olefins displaying turnover numbers (TON) of up to 10(10) for phenyl iodide and turnover frequencies (TOF) of 1.4 x 10(8) h(-1). Deactivated aryl bromides undergo the Heck reaction with styrene with TON and TOF values up to 97,000 and 6063 h-1, respectively. Even aryl chlorides undergo the coupling reaction with olefins with TON up to 920. Complexes 16 catalyze the synthesis of 2,3-disubstituted indenones and indoles in good yields via annulation reaction of internal alkynes with o-bromo- or o-chlorobenzaldehyde and o-iodoaniline, respectively.

  DOI：

  10.1002/1615-4169(200202)344:2<172::aid-adsc172>3.0.co;2-9

文献信息

• SAKAMOTO, TAKAO;KONDO, YOSHINORI;YASUHARA, AKITO;YAMANAKA, HIROSHI, HETEROCYCLES, 31,(1990) N, C. 219-221
  作者：SAKAMOTO, TAKAO、KONDO, YOSHINORI、YASUHARA, AKITO、YAMANAKA, HIROSHI

  DOI：——

  日期：——
• US4687775A
  申请人：——

  公开号：US4687775A

  公开（公告）日：1987-08-18
• Oxime-Derived Palladium Complexes as Very Efficient Catalysts for the Heck–Mizoroki Reaction
  作者：Diego A. Alonso、Carmen Nájera、Ma Carmen Pacheco

  DOI：10.1002/1615-4169(200202)344:2<172::aid-adsc172>3.0.co;2-9

  日期：2002.2

  Oxime-derived, chloro-bridged palladacycles 16 are efficient complexes for the Heck vinylation of aryl halides. The isolated catalysts are thermally stable, not sensitive to air or moisture and easily accessible from inexpensive starting materials. The reaction can be performed under aerobic conditions, with aryl iodides, bromides and chlorides with acrylic esters and olefins displaying turnover numbers (TON) of up to 10(10) for phenyl iodide and turnover frequencies (TOF) of 1.4 x 10(8) h(-1). Deactivated aryl bromides undergo the Heck reaction with styrene with TON and TOF values up to 97,000 and 6063 h-1, respectively. Even aryl chlorides undergo the coupling reaction with olefins with TON up to 920. Complexes 16 catalyze the synthesis of 2,3-disubstituted indenones and indoles in good yields via annulation reaction of internal alkynes with o-bromo- or o-chlorobenzaldehyde and o-iodoaniline, respectively.
• 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
  申请人：G. D. Searle & Co.

  公开号：US04687775A1

  公开（公告）日：1987-08-18

  This invention relates to 2-[(imidazo[1,2-a]pyridinylmethyl)-sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.

  这项发明涉及对溃疡的治疗和预防有用的2-[(咪唑[1,2-a]吡啶基甲基)-亚砜基]-1H-苯并咪唑。