2-(4-氯苯基)-6-羟基-嘧啶-4-羧酸 | 94160-16-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-(4-氯苯基)-6-羟基-嘧啶-4-羧酸
• 中文别名: 赖氨酸磷酸盐
• 英文名称: L-lysine phosphate
• 英文别名: L-Lysine phosphate salt；L(+)-lysine phosphate；L-Lysinium dihydrogen phosphate；[(1S)-5-amino-1-carboxypentyl]azanium;dihydrogen phosphate
• CAS: 94160-16-4
• 化学式: C₆H₁₄N₂O₂*H₃O₄P
• 分子量: 244.185
• InChiKey: XAHQYEAIJGTPET-JEDNCBNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  167
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  L-赖氨酸盐酸盐 在 磷酸 、 三乙胺 作用下， 以 水 为溶剂， 反应 0.5h， 以97%的产率得到2-(4-氯苯基)-6-羟基-嘧啶-4-羧酸
  参考文献：
  名称：

  METHOD FOR PRODUCTION OF A PHOSPHATE SALT OF AN AMINO ACID

  摘要：

  公开号：

  EP2006279B1

文献信息

• [EN] SYNTHESIS OF CAPROLACTAM FROM LYSINE<br/>[FR] SYNTHESE DU CAPROLACTAM A PARTIR DE LA LYSINE
  申请人：UNIV MICHIGAN STATE

  公开号：WO2005123669A1

  公开（公告）日：2005-12-29

  In various embodiments, the present invention can involve a method of synthesizing α-amino-ϵ -caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ϵ-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino -ϵ­ caprolactam, deaminating to produce ϵ-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ϵ-caprolactam and then polymerizing, wherein the ϵ-­caprolactam is derived from L-lysine.

  在各种实施例中，本发明可以涉及一种合成α-氨基-ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐。在其他实施例中，本发明可以涉及合成ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐并脱氨反应产物。在各种实施例中，本发明可以包括将生物质转化为尼龙6的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸以产生α-氨基-ε-己内酰胺，脱氨以产生ε-己内酰胺并聚合成尼龙6，其中L-赖氨酸来源于生物质。在其他实施例中，本发明可以包括制备尼龙6的方法。该方法可以包括合成ε-己内酰胺，然后聚合，其中ε-己内酰胺来源于L-赖氨酸。
• SYNTHESIS OF CAPROLACTAM FROM LYSINE
  申请人：Frost John W.

  公开号：US20090005532A1

  公开（公告）日：2009-01-01

  In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-ε-caprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

  在各种实施例中，本发明涉及一种合成α-氨基-ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐。在其他实施例中，本发明涉及合成ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐，并脱氨反应产物。在各种实施例中，本发明可以包括将生物质转化为尼龙6的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸以产生α-氨基-ε-己内酰胺，脱氨以产生ε-己内酰胺，并聚合成尼龙6，其中L-赖氨酸来源于生物质。在其他实施例中，本发明可以包括制备尼龙6的方法。该方法可以包括合成ε-己内酰胺，然后聚合，其中ε-己内酰胺来源于L-赖氨酸。
• Synthesis of caprolactam from lysine
  申请人：Frost W. John

  公开号：US20070149777A1

  公开（公告）日：2007-06-28

  In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-ε-caprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

  在各种实施例中，本发明涉及一种合成α-氨基-ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸的盐。在其他实施例中，本发明涉及合成ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸的盐并去氨基反应产物。在各种实施例中，本发明可以包括将生物质转化为尼龙6的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸以产生α-氨基-ε-己内酰胺，去氨基以产生ε-己内酰胺并聚合成尼龙6，其中L-赖氨酸来源于生物质。在其他实施例中，本发明可以包括制造尼龙6的方法。该方法可以包括合成ε-己内酰胺然后聚合，其中ε-己内酰胺来源于L-赖氨酸。
• Synthesis of Caprolactam From Lysine
  申请人：Frost John W.

  公开号：US20120142886A1

  公开（公告）日：2012-06-07

  In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-εcaprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

  在各种实施例中，本发明可以涉及一种合成α-氨基-ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐。在其他实施例中，本发明可以涉及合成ε-己内酰胺的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸盐，并脱氨反应产物。在各种实施例中，本发明可以包括将生物质转化为尼龙6的方法。该方法可以包括在含有醇的溶剂中加热L-赖氨酸以产生α-氨基-ε-己内酰胺，脱氨产生ε-己内酰胺，并聚合成尼龙6，其中L-赖氨酸来自生物质。在其他实施例中，本发明可以包括制备尼龙6的方法。该方法可以包括合成ε-己内酰胺，然后聚合，其中ε-己内酰胺来自L-赖氨酸。
• FLUOROPHOSPHATE SURFACTANTS
  申请人：PENG Sheng

  公开号：US20130112908A1

  公开（公告）日：2013-05-09

  This invention is directed to a composition capable of imparting surface effects to a liquid by contacting the liquid with a partially fluorinated phosphate with an ammonium cation (NH 2 R 1 R 2 ) + wherein R 1 and R 2 are independently linear or branched organic groups containing at least one carboxylate moiety and one amino moiety, and optionally be substituted, interrupted, or both with oxygen, sulfur, or nitrogen-containing moieties, or with cyclic alkyl or aryl moieties containing up to 10 carbon atoms.

  本发明涉及一种组合物，通过将含有部分氟化磷酸酯和铵阳离子（NH2R1R2）与液体接触，能够赋予液体表面效应，其中R1和R2是独立的线性或支链有机基团，含有至少一个羧酸酯基团和一个氨基团，并且可以选择地被氧、硫或氮含有的基团或含有最多10个碳原子的环状烷基或芳基取代、中断或两者兼有。