5-Chloro-2-(4-fluorophenyl)pyridine | 1214327-65-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Chloro-2-(4-fluorophenyl)pyridine
• CAS: 1214327-65-7
• 化学式: C₁₁H₇ClFN
• 分子量: 207.635
• InChiKey: OLBFNUMMASEOQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Chloro-2-(4-fluorophenyl)pyridine 在 四(三苯基膦)钯 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 乙醇 、 甲苯 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  안트라센 또는 트라이페닐렌 유도체 및 이를 포함한 유기전계발광소자

  摘要：

  本发明提供了对有机电致发光器件的实际光效率和视角改进有贡献的蒽或三苯基乙烯衍生物。根据本发明的有机电致发光器件包括第一电极；第二电极；位于所述第一电极和第二电极之间的一层或多层有机物层；和封装层，其中所述有机物层或封装层包含由化学式1表示的蒽或三苯基乙烯衍生物。[化学式1]（在上述化学式1中，每个取代基在本发明的详细说明中定义）。

  公开号：

  KR20220030385A
• 作为产物：
  描述：

  2,5-二氯吡啶 、 4-氟苯硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 水 、 甲苯 为溶剂， 反应 24.0h， 生成 5-Chloro-2-(4-fluorophenyl)pyridine
  参考文献：
  名称：

  Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2

  摘要：

  Novel P2X(7) antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X(7) receptor in human and rodent as well as efficacious in rodent pain models. Compound 15a was identified to have oral potency in several pain models in rodent similar to naproxen, gabapentin and pregabalin. Structure-activity relationship (SAR) development and results of pain models are presented. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.037

文献信息

• Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: Part 2
  作者：Stephanie Brumfield、Julius J. Matasi、Deen Tulshian、Michael Czarniecki、William Greenlee、Charles Garlisi、Hongchen Qiu、Kristine Devito、Shu-Cheng Chen、Yongliang Sun、Rosalia Bertorelli、Justin Ansell、William Geiss、Van-Duc Le、Gregory S. Martin、Samuel A. Vellekoop、James Haber、Melissa L. Allard

  DOI：10.1016/j.bmcl.2011.10.037

  日期：2011.12

  Novel P2X(7) antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X(7) receptor in human and rodent as well as efficacious in rodent pain models. Compound 15a was identified to have oral potency in several pain models in rodent similar to naproxen, gabapentin and pregabalin. Structure-activity relationship (SAR) development and results of pain models are presented. (C) 2011 Elsevier Ltd. All rights reserved.
• 안트라센 또는 트라이페닐렌 유도체 및 이를 포함한 유기전계발광소자
  申请人：주식회사 랩토

  公开号：KR20220030385A

  公开（公告）日：2022-03-11

  유기 전계 발광 소자의 실질적인 광 효율과 시야각 향상에 기여하는 안트라센 또는 트라이페닐렌 유도체를 제공한다. 본 발명에 따른 유기 전계 발광 소자는, 제1 전극; 제2 전극; 상기 제1 전극과 제2 전극 사이에 배치된 1층 이상의 유기물층; 및 캡핑층을 포함하고, 상기 유기물층 또는 캡핑층은 하기 화학식 1로 표시되는 안트라센 또는 트라이페닐렌 유도체를 포함한다. [화학식 1] (상기 화학식 1에서 각 치환기들은 발명의 상세한 설명에서 정의한 바와 같다.)

  本发明提供了对有机电致发光器件的实际光效率和视角改进有贡献的蒽或三苯基乙烯衍生物。根据本发明的有机电致发光器件包括第一电极；第二电极；位于所述第一电极和第二电极之间的一层或多层有机物层；和封装层，其中所述有机物层或封装层包含由化学式1表示的蒽或三苯基乙烯衍生物。[化学式1]（在上述化学式1中，每个取代基在本发明的详细说明中定义）。