4.5-Bis-(benzo<1.3>dioxol-5-yl)-1-benzyl-imidazol | 18874-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 4.5-Bis-(benzo<1.3>dioxol-5-yl)-1-benzyl-imidazol
• 英文别名: 4,5-bis-benzo[1,3]dioxol-5-yl-1-benzyl-1H-imidazole；4,5-Bis(1,3-benzodioxol-5-yl)-1-benzylimidazole
• CAS: 18874-86-7
• 化学式: C₂₄H₁₈N₂O₄
• 分子量: 398.418
• InChiKey: JCVCDGHELPYSPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4.5-Bis-(benzo<1.3>dioxol-5-yl)-1-benzyl-imidazol 在 palladium on activated charcoal 氢气 、 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 77.0h， 生成 2-(4,5-di(benzo[d][1,3]dioxol-6-yl)-1H-imidazol-2-yl)pyridine
  参考文献：
  名称：

  Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors

  摘要：

  Inhibitors of the MAP kinase p38, potentially useful for the treatment of rheumatoid arthritis and inflammatory diseases, were found to exhibit antifungal activity. We have developed a new diversity-oriented strategy leading to concise and efficient syntheses of known and new members of this compound class. The strategy is based on carbon-carbon cross-coupling reactions using N-protected 4,5-diiodo-irrtidazoles as the starting templates. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01834-3

文献信息

• Design and novel synthesis of aryl-heteroaryl-imidazole MAP kinase inhibitors
  作者：Markus R Dobler

  DOI：10.1016/s0040-4039(03)01834-3

  日期：2003.9

  Inhibitors of the MAP kinase p38, potentially useful for the treatment of rheumatoid arthritis and inflammatory diseases, were found to exhibit antifungal activity. We have developed a new diversity-oriented strategy leading to concise and efficient syntheses of known and new members of this compound class. The strategy is based on carbon-carbon cross-coupling reactions using N-protected 4,5-diiodo-irrtidazoles as the starting templates. (C) 2003 Elsevier Ltd. All rights reserved.