2-(4-甲氧基苯基)-3-吡啶-2-基-1,3-噻唑烷-4-酮 | 62959-24-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(4-甲氧基苯基)-3-吡啶-2-基-1,3-噻唑烷-4-酮
• 英文名称: 2-(4-methoxyphenyl)-3-(pyridin-2-yl)-1,3-thiazolidin-4-one
• 英文别名: 2-(4-methoxyphenyl)-3-pyridin-2-yl-thiazolidin-4-one；2-(4-methoxyphenyl)-3-pyridin-2-yl-1,3-thiazolidin-4-one
• CAS: 62959-24-4
• 化学式: C₁₅H₁₄N₂O₂S
• 分子量: 286.354
• InChiKey: QIJNOCPKROYRSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2N-[4-methoxybenzalidiene]aminopyridine 、 巯基乙酸 在 三氟化硼 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 0.42h， 生成 2-(4-甲氧基苯基)-3-吡啶-2-基-1,3-噻唑烷-4-酮
  参考文献：
  名称：

  Ultrasonics promoted synthesis of thiazolidinones from 2-aminopyridine and 2-picolilamine

  摘要：

  The efficient multicomponent synthesis of thiazolidinones from the reaction of arenealdehydes, mercaptoacetic acid and 2-picolilamine or 2-aminopyridine under ultrasound irradiation are reported. The reaction with 2-aminopyridine needs a Lewis acid catalysis to afford the corresponding 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones. All novel compounds were identified and characterized by H-1 and C-13 NMR spectra. Applying the sonochemical methodology, two series of heterocyclic thiazolidinones were synthesized in good yields after short reaction times. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2012.03.004

文献信息

• Rawal, Ravindra K.; Srivastava, Tumul; Haq, Journal of Chemical Research, 2004, # 5, p. 368 - 369
  作者：Rawal, Ravindra K.、Srivastava, Tumul、Haq、Katti

  DOI：——

  日期：——
• Ultrasonics promoted synthesis of thiazolidinones from 2-aminopyridine and 2-picolilamine
  作者：Daniela P. Gouvêa、Valéria D.O. Bareño、Juliano Bosenbecker、Bruna B. Drawanz、Patrícia D. Neuenfeldt、Geonir M. Siqueira、Wilson Cunico

  DOI：10.1016/j.ultsonch.2012.03.004

  日期：2012.11

  The efficient multicomponent synthesis of thiazolidinones from the reaction of arenealdehydes, mercaptoacetic acid and 2-picolilamine or 2-aminopyridine under ultrasound irradiation are reported. The reaction with 2-aminopyridine needs a Lewis acid catalysis to afford the corresponding 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones. All novel compounds were identified and characterized by H-1 and C-13 NMR spectra. Applying the sonochemical methodology, two series of heterocyclic thiazolidinones were synthesized in good yields after short reaction times. (C) 2012 Elsevier B.V. All rights reserved.