N,N'-bis(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride | 1133825-41-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
• 英文别名: N,N'-di(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid hydrochloride；2-[2-[Carboxymethyl-[(2-hydroxy-5-methylphenyl)methyl]amino]ethyl-[(2-hydroxy-5-methylphenyl)methyl]amino]acetic acid;hydrochloride
• CAS: 1133825-41-8
• 化学式: C₂₂H₂₈N₂O₆*ClH
• 分子量: 452.935
• InChiKey: DTCBIXFQLSORHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  122
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride 在 双氧水 、 氧气 、 铁粉 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 N,N'-di(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid iron(III) chelate sodium salt
  参考文献：
  名称：

  A process for the preparation of Fe(III) chelates of N,N'-di(2-hydroxybenzyl)-ethylenediamine-N,N'-diacetic acid and its derivatives

  摘要：

  公开号：

  EP2289869B1
• 作为产物：
  描述：

  N,N'-bis(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid 在 盐酸 作用下， 以 水 为溶剂， 生成 N,N'-bis(2-hydroxy-5-methylbenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride
  参考文献：
  名称：

  A process for the preparation of N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and its derivatives

  摘要：

  公开号：

  EP2039679B1

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF FE(III) CHELATES OF N,N'-DI(2-HYDROXYBENZYL)-ETHYLENEDIAMINE-N,N'-DIACETIC ACID AND ITS DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE CHÉLATES DE FE(III) DE L'ACIDE N,N'-DI(2-HYDROXYBENZYL)-ÉTHYLÈNEDIAMINE-N,N'-DIACÉTIQUE ET SES DÉRIVÉS
  申请人：PRZED PROD CONSULTINGOWE ADOB SP Z O O SP K

  公开号：WO2011006763A1

  公开（公告）日：2011-01-20

  The invention relates to the process for the preparation of iron(lll) chelates of N, N'- di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C1 -C4 alkyl, CH2OH, SO3M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.

  该发明涉及一种制备铁（III）螯合物N，N'-二（2-羟基苯甲基）乙二胺-N，N'-二乙酸及其衍生物的过程，其化学式为（I），其中两个R取代基具有相同的含义，代表H，C1-C4烷基，CH2OH，SO3M或COOM，M为钠，钾或铵阳离子，其中通过将相应的螯合剂的水溶液通过金属铁的块状床在流动反应器中循环，同时通过在流动反应器中通过螯合剂的水溶液吹送空气或氧气，可选地在过氧化氢溶液的存在下，制备出化学式（I）的螯合物，用作植物肥料的组分。
• PROCESS FOR THE PREPARATION OF N,N'-BIS(2-HYDROXYBENZYL)ETHYLENEDIAMINE-N,N'-DIACETIC ACID AND ITS DERIVATIVES
  申请人：Nawrocki Adam

  公开号：US20100168469A1

  公开（公告）日：2010-07-01

  The invention relates to a process for the preparation of N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid and its derivatives of general formula (I), wherein both R have the same meaning and are selected from H, C 1 -C 4 alkyl, CH 2 OH, SO 3 M, and COOM; and all M have the same meaning and represent hydrogen atom, Na, K or NH 4 ; which comprises reductive amination of glyoxylic acid with a salan compound of general formula (II), in the presence of an amine proton acceptor. The compounds of formula (I) can be used as chelating agents for micronutrients in fertilizer preparations for plants.

  本发明涉及一种制备N，N'-双（2-羟基苯甲基）-乙二胺-N，N'-二乙酸及其通式（I）衍生物的过程，其中两个R具有相同的含义，可选择自H，C1-C4烷基，CH2OH，SO3M和COOM中；所有的M具有相同的含义，代表氢原子，Na，K或NH4；该过程包括在胺质子受体的存在下，用通式（II）的萨兰化合物对乙酰乙酸进行还原胺化。通式（I）的化合物可用作植物肥料制备中微量营养素的螯合剂。
• A PROCESS FOR THE PREPARATION OF SALTS OF N,N'-DISUBSTITUTED ETHYLENEDIAMINE-N,N'-DIACETIC ACID DERIVATIVES AND THEIR USE
  申请人：Przedsiebiorstwo Produkcyjno-Consultingowe ADOB Sp. z o.o. Sp. jawna

  公开号：EP3848349A1

  公开（公告）日：2021-07-14

  A process of the preparation of the salts of N,N'-disubstituted ethylenediamine-N,N'-diacetic acid derivatives of the formula (IA), by alkylation of N-substituted glycine derivative of the formula (II) with 1,2-dichloroethane; and a process the preparation of acid addition salts of the formula (IB), by acidification of the salt of the formula (IB) with a suitable acid; and the use of the salts of the formula (IA) and (IB) thus obtained in the preparation of iron(III) or zinc(II) chelates. In the formulae, R represents hydrogen atom or CH3 group, M represents sodium or potassium cation and X represents HCl or H2SO4.

  一种通过用 1,2-二氯乙烷对式(II)的 N-取代甘氨酸衍生物进行烷基化而制备式(IA)的 N,N'-二取代乙二胺-N,N'-二乙酸衍生物盐的工艺；以及制备式（IB）的酸加成盐的工艺，方法是用适当的酸将式（IB）的盐酸化；并将由此获得的式(IA)和(IB)的盐用于制备铁(III)或锌(II)螯合物。式中，R 代表氢原子或 CH3 基团，M 代表钠或钾阳离子，X 代表 HCl 或 H2SO4。
• PROCESS FOR THE PREPARATION OF FE(III) CHELATES OF N,N'-DI(2-HYDROXYBENZYL)-ETHYLENEDIAMINE-N,N'-DIACETIC ACID AND ITS DERIVATIVES
  申请人：Olszewski Radoslaw

  公开号：US20120108835A1

  公开（公告）日：2012-05-03

  The invention relates to the process for the preparation of iron(III) chelates of N,N-di(2-hydroxybenzyl)ethylenediamine-N,N′-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C 1 -C 4 alkyl, CH 2 OH, SO 3 M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.
• US8431734B2
  申请人：——

  公开号：US8431734B2

  公开（公告）日：2013-04-30