Trisphosphine oxide | 4851-85-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: Trisphosphine oxide
• 英文别名: tris(bromomethyl)phosphine oxide；tri(bromomethyl)phosphine oxide；tris-bromomethyl-phosphane oxide；Tris-(brommethyl)-phosphinoxid；Tri-(brommethyl)-phosphinoxid；Tris(brommethyl)phosphinoxid；bis(bromomethyl)phosphoryl-bromomethane
• CAS: 4851-85-8
• 化学式: C₃H₆Br₃OP
• 分子量: 328.766
• InChiKey: BSGZXKYGLBFWCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Trisphosphine oxide 在 sodium selenite 作用下， 以 四氢呋喃 为溶剂， 反应 1.33h， 以69%的产率得到5-(bromomethyl)-5-oxo-1,3,2λ4, 5λ5-dioxaselenaphosphinan-2-one
  参考文献：
  名称：

  Synthesis, Spectral Characterization and Antimicrobial Activity of Novel 5-[(Substituted Methyl]-5-oxo-1,3,2λ4,5λ5-dioxaselena Phosphinan-2-ones

  摘要：

  A series of novel 5-[(substituted) methyl]-5-oxo-1,3,2 lambda(4),5 lambda(5)-dioxa selenaphosphinan-2-ones (4-17) were successfully synthesized from tris(bromomethyl)phosphine oxide (I) and sodium selenite (2) to form the intermediate(3) which on further treatment with various alcohols/ thiols/ phenols/ aminoacid esters afforded the title compounds (4-17) and their structures were established by multinuclear NMR (H-1-, C-13- and P-31-) and mass spectral data. Their antimicrobial activity was evaluated and they exhibited promising antibacterial activity.

  DOI：

  10.3987/com-10-11910
• 作为产物：
  描述：

  四羟甲基氯化磷 在 sodium hydroxide 、 氢溴酸 、 双氧水 、 乙酸酐 作用下， 以68.5%的产率得到Trisphosphine oxide
  参考文献：
  名称：

  Kron, T. E.; Tsvetkov, E. N., Journal of general chemistry of the USSR, 1985, vol. 55, # 3, p. 496 - 499

  摘要：

  DOI：

文献信息

• Synthesis, spectral characterisation and anti-microbial activity of novel 3-substituted-2, 4-dihydro-12<i>H</i>-3λ⁵-tribenzo [<i>f, j, n</i>] [1, 5, 9,12, 3] dioxadiazaphosphacyclopentadecine-3-selones
  作者：S. Subba Reddy、V. Koteswara Rao、E. Dadapeer、C. Naga Raju

  DOI：10.3184/030823409x465358

  日期：2009.7

  Tris(bromomethyl)phosphineoxide and 2-[(2-[( Z)-1-(2-hydroxyphenyl)methylidene]aminophenyl)imino]methylphenol have been utilised as precursors in the synthesis of novel pentaco-ordinate dioxadiazaphosphacyclopentadecines[e.g. 3-[(2-hydroxyethoxy)methyl]-2,4-dihydro-12 H-3λ⁵-tribenzo[ f, j, n][1,5,9,12,3]dioxadiazaphosphacyclopentadecine-3-selone] in moderate (overall) yields. The synthesised compounds were characterised by elemental and spectral (IR, ¹H, ¹³C, ³¹P NMR and MS) studies and their anti-microbial activity was evaluated.

  三(溴甲基)亚膦氧化物和 2-[(2-[(Z)-1-(2-羟基苯基)亚甲基]氨基苯基)亚氨基]甲基苯酚已被用作合成新型五价二噁二唑磷杂环十五烷[e.g.]的前体。g.3-[(2-羟基乙氧基)甲基]-2,4-二氢-12 H-3λ5- 三苯并[f,j,n][1,5,9,12,3]二噁二唑磷杂环十五烷-3-硒酮]，收率中等（总体）。通过元素和光谱（IR、1H、13C、31P NMR 和 MS）研究确定了合成化合物的特征，并评估了它们的抗微生物活性。
• Romanenko, V. D.; Tovstenko, V. I.; Kozlov, E. S., Journal of general chemistry of the USSR, 1980, vol. 50, # 5, p. 802 - 807
  作者：Romanenko, V. D.、Tovstenko, V. I.、Kozlov, E. S.、Markovskii, L. N.

  DOI：——

  日期：——
• Applications of Iodotrimethylsilane for the Synthesis of Iodophosphines, Iodophosphoranes, and Iodomethylphosphine Oxides
  作者：V. D. Romanenko、V. I. Tovstenko、L. N. Markovski

  DOI：10.1055/s-1980-29222

  日期：——
• Anteunis,M. et al., Bulletin des Societes Chimiques Belges, 1965, vol. 74, p. 622 - 628
  作者：Anteunis,M. et al.

  DOI：——

  日期：——
• POMAHEHKO V. D.; TOVSTENKO V. I.; KOZLOV EH. S.; MARKOVSKIJ L. N., ZH. OBSHCH. XIMII, 1980, 50, HO 5, 1006-1011
  作者：POMAHEHKO V. D.、 TOVSTENKO V. I.、 KOZLOV EH. S.、 MARKOVSKIJ L. N.

  DOI：——

  日期：——