2-(4-苄氧基-2-甲氧基苯基)-2-羟基-乙胺 | 60372-08-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-(4-苄氧基-2-甲氧基苯基)-2-羟基-乙胺
• 中文别名: 2-（4-苄氧基-2-甲氧基苯基）-2-羟基-乙胺
• 英文名称: 2-Amino-1-(4-benzyloxy-3-methoxy-phenyl)-ethanol
• 英文别名: 2-Amino-1-[4-(benzyloxy)-3-methoxyphenyl]ethan-1-ol；2-amino-1-(3-methoxy-4-phenylmethoxyphenyl)ethanol
• CAS: 60372-08-9
• 化学式: C₁₆H₁₉NO₃
• 分子量: 273.332
• InChiKey: VPBRTSGNLMOOQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-苄氧基-3-甲氧基苯甲醛 在 lithium aluminium tetrahydride 、 sodium methylate 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 2-(4-苄氧基-2-甲氧基苯基)-2-羟基-乙胺
  参考文献：
  名称：

  Mnatsakanyan,V.A. et al., Collection of Czechoslovak Chemical Communications, 1977, vol. 42, p. 1421 - 1430

  摘要：

  DOI：

文献信息

• Mnatsakanyan,V.A. et al., Collection of Czechoslovak Chemical Communications, 1977, vol. 42, p. 1421 - 1430
  作者：Mnatsakanyan,V.A. et al.

  DOI：——

  日期：——
• Montmorillonite-K10 Catalyzed Addition OF Trimethylsilylcyanide (TMSCN) to Aldehydes.
  作者：R. Somanathan、I. A. Rivero、Angeles Gama、A. Ochoa、G. Aguirre

  DOI：10.1080/00397919808007179

  日期：1998.6

  Addition of trimethylsilyl cyanide (TMSCN) to aldehydes was catalyzed by Montmorillonite-K10, with subsequent reduction to beta-aminoalcohol.In recent years we have explored a number of methodologies for the preparation of beta-aminoalcohols(1-4), many of which are biologically active and are also versatile intermediates in organic synthesis as highlighted in a recent review article(5).A convenient route to these beta-aminoalcohols, is the addition of trimethylsilyl cyanide (TMSCN) to an aldehyde or ketone in the presence of a Lewis acid catalyst(6) and subsequent hydride reductions(7,8) to beta-aminoalcohol. Many different Lewis acid catalysts, such as Znl(2), AlCl3, BF3, and Ti(OiPr)(4), have been employed in this reaction. The drawback of this protocol is that the Lewis acid is soluble in the reaction media and very often the final silyloxycyanide is recovered from the reaction mixture by a short path vacuum distillation.