(S)-Methyl 1-(6-chloropyrimidin-4-yl) pyrrolidine-2-carboxylate | 944062-56-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-Methyl 1-(6-chloropyrimidin-4-yl) pyrrolidine-2-carboxylate
• 英文别名: methyl (2S)-1-(6-chloropyrimidin-4-yl)pyrrolidine-2-carboxylate
• CAS: 944062-56-0
• 化学式: C₁₀H₁₂ClN₃O₂
• 分子量: 241.677
• InChiKey: WZBQBBZXLXNXFN-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  间溴苯甲腈 、 (S)-Methyl 1-(6-chloropyrimidin-4-yl) pyrrolidine-2-carboxylate 在 (2,2'-bipyridine)nickel(II) dibromide 、 四丁基溴化铵 、 1,2-二溴乙烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以41%的产率得到(S)-methyl 1-[6-(3-cyanophenyl)pyrimidin-4-yl]pyrrolidine-2-carboxylate
  参考文献：
  名称：

  An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides

  摘要：

  通过 4-氨基-6-氯嘧啶与官能化芳基卤化物之间的电化学还原交叉偶联反应，在温和条件下制备了一系列新型 4-氨基-6-芳基嘧啶。该工艺采用牺牲性铁阳极和镍（II）催化剂，能以中等至高产率生成偶联产物。

  DOI：

  10.3390/molecules16075550
• 作为产物：
  描述：

  4,6-二氯嘧啶 、 L-脯氨酸甲酯 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以81%的产率得到(S)-Methyl 1-(6-chloropyrimidin-4-yl) pyrrolidine-2-carboxylate
  参考文献：
  名称：

  Selective mono-amination of dichlorodiazines

  摘要：

  A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of triethylamine as a base, is described. The methodology is general and efficient despite noticeable difference in reactivity between diazines. While dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.05.056

文献信息

• Selective mono-amination of dichlorodiazines
  作者：Stéphane Sengmany、Julie Lebre、Erwan Le Gall、Eric Léonel

  DOI：10.1016/j.tet.2015.05.056

  日期：2015.7

  A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of triethylamine as a base, is described. The methodology is general and efficient despite noticeable difference in reactivity between diazines. While dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature. (C) 2015 Elsevier Ltd. All rights reserved.
• An Electrochemical Synthesis of Functionalized Arylpyrimidines from 4-Amino-6-Chloropyrimidines and Aryl Halides
  作者：Stéphane Sengmany、Erwan Le Gall、Eric Léonel

  DOI：10.3390/molecules16075550

  日期：——

  A range of novel 4-amino-6-arylpyrimidines has been prepared under mild conditions by an electrochemical reductive cross-coupling between 4-amino-6-chloro-pyrimidines and functionalized aryl halides. The process, which employs a sacrificial iron anode in conjunction with a nickel(II) catalyst, allows the formation of coupling products in moderate to high yields.

  通过 4-氨基-6-氯嘧啶与官能化芳基卤化物之间的电化学还原交叉偶联反应，在温和条件下制备了一系列新型 4-氨基-6-芳基嘧啶。该工艺采用牺牲性铁阳极和镍（II）催化剂，能以中等至高产率生成偶联产物。