Methylnaltrexone, (17S)- | 916045-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Methylnaltrexone, (17S)-
• 英文别名: (3S,4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium-7-one
• CAS: 916045-22-2
• 化学式: C21H26NO4+
• 分子量: 356.4
• InChiKey: JVLBPIPGETUEET-UGTAXJHQSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
  申请人：Lightlake Therapeutics, Inc.

  公开号：US20150258019A1

  公开（公告）日：2015-09-17

  Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
• CO-PACKAGED DRUG PRODUCTS
  申请人：Lightlake Therapeutics Inc.

  公开号：US20160008277A1

  公开（公告）日：2016-01-14

  Provided herein are drug products comprising a combination of an opioid receptor agonist and an opioid receptor agonists, including co-packaged drug products comprising an opioid receptor agonist and an opioid receptor antagonist in a delivery device selected from a hand-held auto-injector and a pre-primed nasal delivery device, and methods of prescribing and dispensing same. Methods of lowering opioid overdose risk by providing a combination of an opioid receptor agonist and an opioid receptor agonists, for example by co-packaging an opioid receptor agonist and an opioid receptor antagonist in a delivery device, are also provided.
• COMPOSITIONS FOR DRUG ADMINISTRATION
  申请人：AEGIS THERAPEUTICS, LLC

  公开号：US20180000942A1

  公开（公告）日：2018-01-04

  The present invention provides compositions and methods and for increasing the bioavailability of therapeutic agents in a subject. The compositions include at least one alkyl glycoside and at least one therapeutic agent, wherein the alkylglycoside has an alkyl chain length from about 10 to about 16 carbon atoms.
• US9211253B2
  申请人：——

  公开号：US9211253B2

  公开（公告）日：2015-12-15
• US9468747B2
  申请人：——

  公开号：US9468747B2

  公开（公告）日：2016-10-18