ethyl 2-(1-nitroethyl)-4-oxopentanoate | 1150299-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: ethyl 2-(1-nitroethyl)-4-oxopentanoate
• 英文别名: Ethyl 2-(1-nitroethyl)-4-oxopentanoate
• CAS: 1150299-31-2
• 化学式: C₉H₁₅NO₅
• 分子量: 217.222
• InChiKey: UUGMGQCSLIVNRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  89.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(三甲基硅氧基)丙烯 、 ethyl 3-nitrobut-2-enoate 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.5h， 以75%的产率得到ethyl 2-(1-nitroethyl)-4-oxopentanoate
  参考文献：
  名称：

  β-Nitroacrylates and silyl enol ethers as key starting materials for the synthesis of polyfunctionalized β-nitro esters and 1,2-oxazine-2-oxides

  摘要：

  The reaction of silyl enol ethers with beta-nitroacrylates, in the presence of tetrabutyl ammonium fluoride as catalyst, allows the formation of polyfunctionalized beta-nitro esters, or hexahydro-4H-benzoxazine-2-oxides, depending on the nature of the starting silyl enol ethers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.02.009

文献信息

• [EN] CONCISE PROCESS FOR PREPARING 3-PYRROLIDINE CARBOXYLIC ACID DERIVATIVES<br/>[FR] PROCÉDÉ CONCIS POUR LA PRÉPARATION DE DÉRIVÉS D'ACIDE 3-PYRROLIDINE CARBOXYLIQUE
  申请人：OKINAWA INST SCIENCE & TECH SCHOOL CORP

  公开号：WO2018025295A1

  公开（公告）日：2018-02-08

  The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

  本发明涉及一种制备3-吡咯烷羧酸衍生物的方法，特别是一种制备5-取代的3-吡咯烷羧酸衍生物的简单方法。此外，本发明涉及一种新型吡咯烷羧酸衍生物，其制造方法，含有它的药物组合物以及其用作催化剂的用途。
• Concise process for preparing 3-pyrrolidine carboxylic acid derivatives
  申请人：OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

  公开号：US10988446B2

  公开（公告）日：2021-04-27

  The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.

  本发明涉及一种制备 3-吡咯烷羧酸衍生物的工艺，特别是一种制备 5-取代 3-吡咯烷羧酸衍生物的简单工艺。此外，本发明还涉及一种新型吡咯烷羧酸衍生物、它的制造、含有它的药物组合物以及它作为催化剂的用途。
• CONCISE PROCESS FOR PREPARING 3-PYRROLIDINE CARBOXYLIC ACID DERIVATIVES
  申请人：OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

  公开号：US20190169125A1

  公开（公告）日：2019-06-06

  The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.
• β-Nitroacrylates and silyl enol ethers as key starting materials for the synthesis of polyfunctionalized β-nitro esters and 1,2-oxazine-2-oxides
  作者：Roberto Ballini、Giovanna Bosica、Serena Gabrielli、Alessandro Palmieri

  DOI：10.1016/j.tet.2009.02.009

  日期：2009.4

  The reaction of silyl enol ethers with beta-nitroacrylates, in the presence of tetrabutyl ammonium fluoride as catalyst, allows the formation of polyfunctionalized beta-nitro esters, or hexahydro-4H-benzoxazine-2-oxides, depending on the nature of the starting silyl enol ethers. (C) 2009 Elsevier Ltd. All rights reserved.