3-Methoxy-benzolsulfinsaeure | 105847-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Methoxy-benzolsulfinsaeure
• 英文别名: 3-Methoxybenzenesulfinic acid
• CAS: 105847-32-3
• 化学式: C₇H₈O₃S
• 分子量: 172.205
• InChiKey: HOYVIXAASVMDMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  65.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Methoxy-benzolsulfinsaeure 、 间苯二甲醚 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 以72%的产率得到2,4-dimethoxy-1-((3-methoxyphenyl)sulfinyl)benzene
  参考文献：
  名称：

  二芳基亚砜和选择性合成米经由BF芳硫基砜从芳基亚酸和芳烃3促进的C-S键的形成

  摘要：

  用于二芳基亚砜和选择性合成了一种新的且有效的方法米芳硫基砜已经从容易获得的芳基亚磺酸和芳烃经由一个不寻常的亚磺酰基阳离子实现，提供一系列的结构上不同的产品以优良至在温和的条件下具有优异的产率。值得注意的是，机械的调查建议米从碳酸二芳基亚砜和亚磺酰阳离子通过氧化还原反应和亲电芳香取代处理的顺序生成的芳硫基砜。

  DOI：

  10.1021/acs.orglett.8b01681

文献信息

• BENZOFURO[3,2-c] PYRIDINES AND RELATED ANALOGS AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS FOR THE TREATMENT OF OBESITY, METABOLIC SYNDROME, COGNITION AND SCHIZOPHRENIA
  申请人：GUZZO Peter R.

  公开号：US20120184531A1

  公开（公告）日：2012-07-19

  The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT 6 ) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

  本发明涉及苯并呋喃[3,2-c]吡啶和氮杂环庚烯类似物作为5-羟色胺亚型6（5-HT6）调节剂，包括这些化合物的药物组合物，其制备方法以及使用方法。这些化合物在治疗包括肥胖、代谢综合征、认知障碍、精神分裂症、注意力缺陷多动障碍、躁郁症、罕见和孤儿疾病以及睡眠障碍在内的中枢神经系统疾病中是有用的。所述化合物具有如下式（I）的结构，其中所述取代基在此处描述。
• METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR
  申请人：Coady Daniel Joseph

  公开号：US20120046437A1

  公开（公告）日：2012-02-23

  A salt catalyst comprises an ionic complex of i) a nitrogen base comprising one or more guanidine and/or amidine functional groups, and ii) an oxoacid comprising one or more active acid groups, the active acid groups independently comprising a carbonyl group (C═O), sulfoxide group (S═O), and/or a phosphonyl group (P═O) bonded to one or more active hydroxy groups; wherein a ratio of moles of the active hydroxy groups to moles of the guanidine and/or amidine functional groups is greater than 0 and less than 2.0. The salt catalysts are capable of catalyzing ring opening polymerization of cyclic carbonyl compounds.

  一种盐催化剂包括离子复合物，其中i）氮碱包括一个或多个胍啶和/或酰胺基团，和ii）含有一个或多个活性酸基团的氧酸，这些活性酸基团独立地包括与一个或多个活性羟基团结合的羰基（C═O）、亚氧基（S═O）和/或膦酰基（P═O）；其中活性羟基团的摩尔数与胍啶和/或酰胺基团的摩尔数的比值大于0且小于2.0。这些盐催化剂能够催化环状羰基化合物的开环聚合。
• EPIMINOCYCLOALKYL[b] INDOLE DERIVATIVES AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS AND USES THEREOF
  申请人：GUZZO Peter R.

  公开号：US20110112122A1

  公开（公告）日：2011-05-12

  The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT 6 ) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) with the substituents being described herein.

  本发明涉及作为血清素亚型6（5-HT6）调节剂的环氨基环烷基[b]吲哚衍生物，包括这些化合物的制药组合物，以及其制备和使用的方法。这些化合物在治疗中枢神经系统疾病，包括肥胖症、代谢综合征、认知和精神分裂症方面具有用处。所述化合物具有公式（I）的结构，其中取代基如下所述。
• Convenient synthesis of 2-chloro-3-substituted quinoxalines by visible-light-induced radical cascade cyclization of <i>ortho</i>-diisocyanoarenes with sulfinic acids
  作者：Palani Natarajan、Partigya、Meena

  DOI：10.1039/d3nj05642b

  日期：——

  ortho-diisocyanoarenes (1) with alkyl(aryl)sulfinic acids (2) and trichloroisocyanuric acid has been developed. Also, a plausible reaction mechanism and synthetic uses of 2-chloro-3-substituted quinoxalines (3) towards a few 2,3-di-unsymmetrically-substituted quinoxalines have been described. This novel approach easily accesses 2-chloro-3-substituted quinoxalines (3) in good yields, without using elevated temperatures

  2-氯-3-取代的喹喔啉 ( 3 ) 是合成 2,3-二不对称取代的喹喔啉（包括喹那西林）的重要前体，喹那西林已被证明可有效对抗多种可移植疾病和癌细胞。尽管事实上有两种方法来生产 2-氯-3-取代的喹喔啉 ( 3 )，但这两种方法都受到高温、金属污染和有毒试剂的阻碍。已经开发出邻二异氰基芳烃 ( 1 ) 与烷基(芳基)亚磺酸 ( 2 ) 和三氯异氰尿酸的可见光诱导自由基级联环化。此外，还描述了2-氯-3-取代的喹喔啉( 3 )对一些2,3-二-不对称取代的喹喔啉的合理反应机理和合成用途。这种新方法可以轻松地以良好的产率获得 2-氯-3-取代的喹喔啉 ( 3 )，无需使用高温或金属或有毒试剂。
• 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE
  申请人：Oxford Drug Design Limited

  公开号：US20200039929A1

  公开（公告）日：2020-02-06

  The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(arylsulfinyl)-acetamide compounds that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-t RNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.