2-nitro-benzenesulfonyl bromide | 1950-72-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-nitro-benzenesulfonyl bromide
• 英文别名: 2-Nitro-benzolsulfonylbromid；o-Nitrobenzo-sulfobromid；2-Nitrobenzenesulfonyl bromide
• CAS: 1950-72-7
• 化学式: C₆H₄BrNO₄S
• 分子量: 266.072
• InChiKey: VHOGAUNEODDEKR-UHFFFAOYSA-N

物化性质

• 熔点：
  63-64 °C
• 沸点：
  400.5±47.0 °C(Predicted)
• 密度：
  1.904±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-氨基丙基三乙氧基硅烷 、 2-nitro-benzenesulfonyl bromide 生成 2-nitro-N-(3-triethoxysilylpropyl)benzenesulfonamide
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  双(2-硝基苯基)二硫化物 在 溴 、 溶剂黄146 作用下， 生成 2-nitro-benzenesulfonyl bromide
  参考文献：
  名称：

  Hunter; Sorenson, Journal of the American Chemical Society, 1932, vol. 54, p. 3365

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING AMINO ACID DERIVATIVES
  申请人：API CORPORATION

  公开号：US20210403427A1

  公开（公告）日：2021-12-30

  The present invention aims to provide a method for producing a (2S,5R)-5-(protected oxyamino)-piperidine-2-carboxylic acid derivative at a low cost that can be performed under mild reaction conditions not requiring a facility at an extremely low temperature, is safer, can control the quality of the desired product with ease, and shows good workability in the site of production. A method for producing a compound represented by the formula (2): wherein PG 1 is an amino-protecting group, PG 2 is an amino-protecting group, PG 3 is a hydroxyl-protecting group, LG is a leaving group, and R is a hydrocarbon group having 1-8 carbon atoms and optionally having substituent(s), including a step of reacting a compound represented by the formula (1): wherein each symbol is as defined above, with a hydroxylamine derivative represented by the formula PG 2 NHOPG 3 wherein each symbol is as defined above, in the presence of a base in a solvent.

  本发明旨在提供一种低成本的方法，用于在温和反应条件下生产(2S,5R)-5-(保护氧氨基)-哌啶-2-羧酸衍生物，不需要极低温度设施，更安全，并且可以轻松控制所需产品的质量，在生产现场具有良好的可操作性。该方法包括以下步骤：与公式（1）所表示的化合物在溶剂中反应，其中PG1是氨基保护基，PG2是氨基保护基，PG3是羟基保护基，LG是离去基团，R是具有1-8个碳原子的烃基，并且可选地具有取代基，与公式PG2NHOPG3所表示的羟胺衍生物在碱的存在下反应。
• NOVEL CRYSTALLINE ARYLALKYLAMINE COMPOUND AND PROCESS FOR PRODUCING THE SAME
  申请人：MITSUBISHI TANABE PHARMA CORPORATION

  公开号：US20160200679A1

  公开（公告）日：2016-07-14

  The present invention provides novel crystal forms of arylalkylamine compounds. Specifically, the novel crystal forms of 4-(3S-(1R-(1-naphthyl)ethylamino)pyrrolidin-1-yl)phenylacetic acid have excellent stability and therefore are useful as pharmaceutical ingredients. The present invention also provides industrially advantageous processes for producing the arylalkylamine compounds.

  本发明提供了新型芳基烷基胺化合物的晶体形式。具体地，4-(3S-(1R-(1-萘基)乙基氨基)吡咯烷-1-基)苯乙酸的新型晶体形式具有优异的稳定性，因此可以作为药用成分。本发明还提供了工业上有利的生产芳基烷基胺化合物的方法。
• Method for Producing cis-5-hydroxy-2-piperidinecarboxylic Acid Derivative, and Method for Purifying cis-5-hydroxy-2-piperidinecarboxylic Acid
  申请人：API CORPORATION

  公开号：US20150239906A1

  公开（公告）日：2015-08-27

  The present invention aims to provide a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid with high purity, and a method for producing its derivative. The present invention provides a method for producing a cis-5-hydroxy-2-piperidinecarboxylic acid derivative, which method comprises a step of converting cis-5-hydroxy-2-piperidinecarboxylic acid into a compound(s) of Formula (1) and/or Formula (2) (wherein R 1 represents a protective group for an amino group, and R2 represents a C 1 -C 6 alkyl group), and a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid.

  本发明旨在提供一种高纯度纯化顺式-5-羟基-2-哌啶羧酸的方法，以及其衍生物的生产方法。本发明提供了一种生产顺式-5-羟基-2-哌啶羧酸衍生物的方法，该方法包括将顺式-5-羟基-2-哌啶羧酸转化为式（1）和/或式（2）化合物的步骤（其中R1代表氨基的保护基，R2代表C1-C6烷基），以及一种纯化顺式-5-羟基-2-哌啶羧酸的方法。
• PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND
  申请人：Yamamoto Kazuhiro

  公开号：US20110034696A1

  公开（公告）日：2011-02-10

  To provide a process for producing an anthranilamide having the 3-position of pyrazole substituted by a bromine atom, or its salt. A process for producing an anthranilamide compound represented by the formula (I) or its salt: which comprises reacting a compound represented by the formula (II): (wherein Z is 2-pyridyl, 3-pyridyl, 4-pyridyl or benzene substituted by a nitro group), with a brominating agent, to produce a compound represented by the formula (III): and further reacting the compound of the formula (III) with an oxidizing agent.

  提供一种制备在吡唑的3位被溴原子取代的蒽酰胺或其盐的过程。该过程包括反应式（II）的化合物：（其中Z是2-吡啶基，3-吡啶基，4-吡啶基或被硝基取代的苯基），与溴化试剂反应，生成式（III）的化合物：进一步将式（III）的化合物与氧化剂反应，制备式（I）的蒽酰胺化合物或其盐。
• CYCLIC AMINO COMPOUNDS
  申请人：Sankyo Company Limited

  公开号：EP1063230A1

  公开（公告）日：2000-12-27

  Cyclic amino compounds represented by general formula (I) or pharmacologically acceptable salts thereof having an excellent antiplatelet aggregation effect; etc. and thus being useful as preventives or remedies for embolism, thrombosis or arterial sclerosis wherein R1 represents optionally substituted phenyl; R2 represents optionally substituted aliphatic acyl, optionally substituted benzoyl or alkoxycarbonyl; and R3 represents substituted and optionally ring-fused saturated cyclic amino.

  通式(I)代表的环状氨基化合物或其药理上可接受的盐，具有优异的抗血小板聚集作用等，因此可作为栓塞、血栓形成或动脉硬化的预防剂或治疗剂 其中R1代表任选取代的苯基；R2代表任选取代的脂肪族酰基、任选取代的苯甲酰基或烷氧基羰基；R3代表取代的和任选环融的饱和环状氨基。