1-(methylthio)thiocarbonyl-1-phenylhydrazine | 25554-73-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(methylthio)thiocarbonyl-1-phenylhydrazine
• 英文别名: methyl 1-phenylhydrazinecarbodithioate；1-(Methylthio)thiocarbonyl-1-phenyl-hydrazin；phenyl-hydrazinecarbodithioic Acid Methyl Ester；Carbazic acid, 2-phenyldithio-, methyl ester；methyl N-amino-N-phenylcarbamodithioate
• CAS: 25554-73-8
• 化学式: C₈H₁₀N₂S₂
• 分子量: 198.313
• InChiKey: GQNVUPCGNGAPNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  86.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  1-(methylthio)thiocarbonyl-1-phenylhydrazine 在 4-二甲氨基吡啶 、 三氟化硼乙醚 、 三正丁基氢锡 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 、 甲苯 为溶剂， 反应 35.25h， 生成
  参考文献：
  名称：

  Total Synthesis of Phenanthroindolizidine Alkaloids through an Amidyl Radical Cascade/Rearrangement Reaction

  摘要：

  A short and general synthesis of the phenanthroindolizidine alkaloids is reported, featuring an unusual amidyl radical 5-exo/5-exo/rearrangement cascade of a xanthate precursor. Second, using an amidyl radical 5-exo/6-endo cascade to synthesize a phenanthroindolizidine alkaloid exclusively has been developed through a small structural modification.

  DOI：

  10.1021/ol4025925
• 作为产物：
  描述：

  苯甲醛苯腙 在 盐酸 、 苯肼 作用下， 以 乙醇 为溶剂， 生成 1-(methylthio)thiocarbonyl-1-phenylhydrazine
  参考文献：
  名称：

  Jensen,K.A. et al., Acta Chemica Scandinavica (1947), 1969, vol. 23, p. 1916 - 1934

  摘要：

  DOI：

文献信息

• Inhibitors of Src and other protein kinases
  申请人：——

  公开号：US20030144309A1

  公开（公告）日：2003-07-31

  The present invention provides compounds of formula I: 1 wherein A is N or CR, and G, R 1 , R 2 and R 3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明提供了式I的化合物： 其中A为N或CR，而G、R1、R2和R3如规范中所述。这些化合物是蛋白激酶的抑制剂，特别是涉及细胞增殖、细胞死亡和对细胞外刺激反应的哺乳动物Src蛋白激酶的抑制剂。该发明还涉及制备这些抑制剂的方法。该发明还提供了包括该发明的抑制剂的药物组合物以及利用这些组合物在治疗和预防各种疾病中的方法。
• Model studies toward the synthesis of kirkine
  作者：Gillian L. Barclay、B�atrice Quiclet-Sire、Graciela Sanchez-Jimenez、Samir Z. Zard

  DOI：10.1039/b416763e

  日期：——

  In model studies towards the synthesis of kirkine, the carbon skeleton was constructed using a radical cascade reaction. Two different approaches towards the synthesis have been examined as well as the regioselectivity of the radical cyclisation.

  在有关合成菊红的模型研究中，使用自由基级联反应构建了碳骨架。已经研究了两种不同的合成方法以及自由基环化的区域选择性。
• Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine
  作者：Aurélien Biechy、Shuji Hachisu、Béatrice Quiclet-Sire、Louis Ricard、Samir Z. Zard

  DOI：10.1016/j.tet.2009.04.027

  日期：2009.8

  radical was developed, allowing the rapid construction of galanthan frameworks. It was applied to a concise, stereo/regio-selective and tin-free total synthesis of the natural product (±)-fortucine. This in turn resulted in the correction of the structure of kirkine.

  开发了由氮中心（ami基）自由基引发的自由基级联反应，从而可以快速构建加兰坦骨架。将其应用于天然产物（±）-精氨酸的简明，立体/区域选择性和无锡全合成。这进而导致基尔金结构的校正。
• An expedient synthesis of (±)-γ-lycorane
  作者：Xuan Hoang-Cong、Béatrice Quiclet-Sire、Samir Z. Zard

  DOI：10.1016/s0040-4039(99)00146-x

  日期：1999.3
• A new source of nitrogen centered radicals
  作者：Anne-Claude Callier-Dublanchet、Biatrice Quiclet-Sire、Samir Z. Zard

  DOI：10.1016/0040-4039(95)01878-l

  日期：1995.11

  Exposure of thiocarbazone derivatives 6b-10b, 11c-13c, and 14a-15a to tributylstannane in the presence of AIBN leads to various nitrogen centered radicals which are easily captured by an internal olefin.