tert-butyl N-[(5R)-5-[[3-[[(2R)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-(2-methylpropylamino)-1-oxohexan-2-yl]oxycarbamoyl]benzoyl]amino]oxy-6-(2-methylpropylamino)-6-oxohexyl]carbamate | 1162749-31-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[(5R)-5-[[3-[[(2R)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-(2-methylpropylamino)-1-oxohexan-2-yl]oxycarbamoyl]benzoyl]amino]oxy-6-(2-methylpropylamino)-6-oxohexyl]carbamate
• CAS: 1162749-31-6
• 化学式: C₃₈H₆₄N₆O₁₀
• 分子量: 764.96
• InChiKey: QVUHOUJOKHJVML-LOYHVIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  54
• 可旋转键数：
  26
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  212
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  间苯二甲酸 、 tert-butyl N-[(5R)-5-(1,3-dioxoisoindol-2-yl)oxy-6-(2-methylpropylamino)-6-oxohexyl]carbamate 在 一水合肼 、 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.5h， 以688 mg的产率得到tert-butyl N-[(5R)-5-[[3-[[(2R)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-(2-methylpropylamino)-1-oxohexan-2-yl]oxycarbamoyl]benzoyl]amino]oxy-6-(2-methylpropylamino)-6-oxohexyl]carbamate
  参考文献：
  名称：

  A small synthetic molecule forms selective potassium channels to regulate cell membrane potential and blood vessel tone

  摘要：

  一种分子在细胞膜中形成K+选择性通道，以调节血管肌细胞膜电位和血管张力。

  DOI：

  10.1039/c4ob01420k

文献信息

• Method of Modulating Membrane Potential of a Cell
  申请人：Yang Dan

  公开号：US20090163595A1

  公开（公告）日：2009-06-25

  Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and/or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

  本文提供了使用自组装化合物调节细胞膜的膜电位的方法。本文还提供了使用所披露的自组装化合物调节细胞膜中自然电压依赖离子通道的方法。此外，本文还提供了使用所披露的自组装化合物治疗、预防和/或管理与异常膜电位反应相关的疾病的方法。
• Synthetic Ion Channels
  申请人：Yang Dan

  公开号：US20130244944A1

  公开（公告）日：2013-09-19

  Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
• US9162977B2
  申请人：——

  公开号：US9162977B2

  公开（公告）日：2015-10-20
• US9610263B2
  申请人：——

  公开号：US9610263B2

  公开（公告）日：2017-04-04
• [EN] METHOD OF MODULATING MEMBRANE POTENTIAL OF A CELL<br/>[FR] PROCÉDÉ DE MODULATION DU POTENTIEL MEMBRANAIRE D'UNE CELLULE
  申请人：YANG DAN

  公开号：WO2009089680A1

  公开（公告）日：2009-07-23

  Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and /or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.