2-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinoline | 1174271-15-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinoline
• 英文别名: 2-(4-Methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinoline
• CAS: 1174271-15-8
• 化学式: C₂₄H₁₈N₂O
• 分子量: 350.42
• InChiKey: LFTNJZVTBWYWGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  26.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-溴-2-苯基乙炔-苯 、 3-(4-甲氧基苯基）吡唑 在 copper(l) iodide 、 2,6-二乙基苯胺 、 1,3-bis(2,6-diethylphenyl)-1H-imidazol-3-ium chloride 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 以58%的产率得到2-(4-methoxyphenyl)-5-phenylpyrazolo[5,1-a]isoquinoline
  参考文献：
  名称：

  Route to Pyrazolo[5,1-a]isoquinolines via a Copper-Catalyzed Tandem Reaction of 2-Alkynylbromobenzene with Pyrazole

  摘要：

  A copper-catalyzed tandem reaction of 2-alkynylbromobenzene and pyrazole is described that provides a facile route to pyrazolo[5,1-a]isoquinolines in good yields. During the reaction process, copper(1)-catalyzed hydroamination and C-H activation are involved.

  DOI：

  10.1021/jo400523v

文献信息

• AgOTf-catalyzed tandem reaction of N′-(2-alkynylbenzylidene)hydrazide with alkyne
  作者：Zhiyuan Chen、Xiaodi Yang、Jie Wu

  DOI：10.1039/b904498a

  日期：——

  AgOTf-catalyzed tandem reactions of N'-(2-alkynylbenzylidene)hydrazides with various alkynes under mild conditions are described, which generate fused 1,2-dihydroisoquinolines in good to excellent yields.

  描述了在温和的条件下，N'-（2-炔基亚苄基）酰肼与各种炔烃的AgOTf催化串联反应，该反应以良好或极好的收率产生了稠合的1,2-二氢异喹啉。
• Metal Cocatalyzed Tandem Alkynylative Cyclization Reaction of in Situ Formed<i>N</i>-Iminoisoquinolinium Ylides with Bromoalkynes via C–H Bond Activation
  作者：Ping Huang、Qin Yang、Zhiyuan Chen、Qiuping Ding、Jingshi Xu、Yiyuan Peng

  DOI：10.1021/jo3013429

  日期：2012.9.21

  Silver triflate and copper(I) iodide cocatalyzed direct alkynylation and cyclization reaction of in situ formed N-iminoisoquinolinium ylides with bromoalkynes is described. The reaction proceeds efficiently through a combination of C–H activation and subsequent tandem reaction in one pot, leading to diverse H-pyrazolo[5,1-a]isoquinolines in good yields under mild reaction conditions.

  描述了三氟甲磺酸银和碘化铜（I）共同催化原位形成的N-亚氨基异喹啉鎓碘化物与溴炔烃的直接炔基化和环化反应。在一个反应​​釜中，通过C–H活化和随后的串联反应的组合，该反应得以有效进行，从而在温和的反应条件下以高收率产生了多种H-吡唑并[5,1- a ]异喹啉。
• Facile Assembly of <i>H</i> ‐Pyrazolo[5,1‐ <i>a</i> ]isoquinolines <i>via</i> Silver Triflate‐Catalyzed One‐Pot Tandem Reaction of 2‐Alkynyl‐ benzaldehyde, Sulfonohydrazide, and Ketone or Aldehyde
  作者：Xingxin Yu、Shengqing Ye、Jie Wu

  DOI：10.1002/adsc.201000176

  日期：2010.10.9

  AbstractA novel and efficient route for the generation of H‐pyrazolo[5,1‐a]isoquinolines via silver triflate‐catalyzed one‐pot tandem reaction of 2‐alkynylbenzaldehyde, sulfonohydrazide, and ketone or aldehyde is described. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity.
• Route to Pyrazolo[5,1-<i>a</i>]isoquinolines via a Copper-Catalyzed Tandem Reaction of 2-Alkynylbromobenzene with Pyrazole
  作者：Xiaolin Pan、Yong Luo、Jie Wu

  DOI：10.1021/jo400523v

  日期：2013.6.7

  A copper-catalyzed tandem reaction of 2-alkynylbromobenzene and pyrazole is described that provides a facile route to pyrazolo[5,1-a]isoquinolines in good yields. During the reaction process, copper(1)-catalyzed hydroamination and C-H activation are involved.