(3,5-dimethylphenyl)(p-tolyl)methanone | 13183-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-dimethylphenyl)(p-tolyl)methanone
• 英文别名: (3,5-Dimethyl-phenyl)-p-tolyl-methanone；(3,5-dimethylphenyl)-(4-methylphenyl)methanone
• CAS: 13183-57-8
• 化学式: C₁₆H₁₆O
• mdl: MFCD11210907
• 分子量: 224.302
• InChiKey: IMCXSIIFTRLECD-UHFFFAOYSA-N

物化性质

• 熔点：
  75.0-75.5 °C(Solv: methanol (67-56-1))
• 沸点：
  371.0±31.0 °C(Predicted)
• 密度：
  1.036±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.187
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3,5-dimethylphenyl)(p-tolyl)methanone 在 sodium hydroxide 、 一水合肼 、 二乙二醇 作用下， 生成 (3,5-dimethyl-phenyl)-(4-methyl-phenyl)-methane
  参考文献：
  名称：

  Rearrangements of Aryl Sulfones. I. The Metalation and Rearrangement of Mesityl Phenyl Sulfone¹

  摘要：

  DOI：

  10.1021/ja01547a038
• 作为产物：
  描述：

  1-甲基-4-(硝基甲基)苯 在 t-BuXPhos 、 tris-(dibenzylideneacetone)dipalladium(0) 、 disodium hydrogenphosphate 、 potassium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 2.5h， 生成 (3,5-dimethylphenyl)(p-tolyl)methanone
  参考文献：
  名称：

  Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

  摘要：

  Catalytic conditions for the alpha-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

  DOI：

  10.1021/acs.orglett.5b02793

文献信息

• Palladium-Catalyzed Denitrogenative Synthesis of Aryl Ketones from Arylhydrazines and Nitriles Using O₂ as Sole Oxidant
  作者：Xu Wang、Yubing Huang、Yanli Xu、Xiaodong Tang、Wanqing Wu、Huanfeng Jiang

  DOI：10.1021/acs.joc.6b02697

  日期：2017.2.17

  An efficient and simple palladium-catalyzed approach for the synthesis of aryl ketones from low-cost nitriles and arylhydrazines using molecular oxygen (O2) as sole oxidant via C–N bond cleavage is reported. Various aryl ketones were synthesized in moderate to good yields under mild conditions. A possible mechanism involving the PdII/Pd0 catalytic cycle process is depicted, and a cationic palladium

  据报道，一种有效且简单的钯催化方法可通过低成本的腈和芳肼，使用分子氧（O 2）作为唯一氧化剂通过C–N键断裂来合成芳基酮。在温和的条件下以中等至良好的产率合成了各种芳基酮。描述了涉及Pd II / Pd 0催化循环过程的可能机理，并通过ESI-MS检测了阳离子钯中间体。
• Palladium-catalyzed Coupling of Benzoyl Halides with Aryltrifluorosilanes Leading to Diaryl Ketones
  作者：Yohei Ogiwara、Yuki Maegawa、Daisuke Sakino、Norio Sakai

  DOI：10.1246/cl.160223

  日期：2016.7.5

  Acyl–aryl Hiyama coupling of acyl halides with arylsilanes has been achieved by employing a palladium/phosphine catalyst system. A variety of acyl chlorides and fluorides can be applied for coupling with arylsilicon reagents, and unsymmetrical benzophenone derivatives can be prepared using this protocol.

  已经通过使用钯/膦催化剂体系实现了酰基卤与芳基硅烷的酰基-芳基 Hiyama 偶联。多种酰氯和氟化物可用于与芳基硅试剂偶联，并且可以使用该协议制备不对称的二苯甲酮衍生物。
• Novel multi-branched polymer
  申请人：Aoyagi Koichiro

  公开号：US20070142504A1

  公开（公告）日：2007-06-21

  The aim of the present invention is to provide a multi-branched polymer, in which branch terminals can be easily modified and which have a high degree of branching and narrow dispersion. By polymerizing a compound having 2 or more polymerization-initiation sites and polymerizable unsaturated bonds with a living radical polymerization method using a metal catalyst, it is possible to produce a multi-branched polymer with narrow dispersion and a high degree of branching and having repeating units represented by the formula (I): wherein R 1 to R 3 each independently represents hydrogen or a hydrocarbon group, R 1 may be bonded to R 3 to form a ring; X represents a connecting group having a valence of 3 or higher; Y may be the same or different and each represents a functional group which may have a halogen atom at a terminal thereof; and a is an integer of 2 or larger.

  本发明的目的是提供一种多支化聚合物，其中支链末端可以容易地修改，并具有高度分支和窄分散度。通过使用金属催化剂的活性自由基聚合方法聚合具有2个或更多聚合引发位点和可聚合不饱和键的化合物，可以产生具有窄分散度和高度分支的多支化聚合物，并具有由式（I）表示的重复单元：其中R1至R3各自独立表示氢或碳氢基团，R1可以与R3连接形成环；X表示具有3或更高价的连接基团；Y可以相同或不同，每个表示具有末端可能有卤素原子的功能基团；a是2或更大的整数。
• POLYMER ELECTROLYTE MEMBRANE
  申请人：LG Chem, Ltd.

  公开号：EP2345682A2

  公开（公告）日：2011-07-20

  Disclosed are a multi-block copolymer, its producing method and an electrolyte membrane using the same. The multi-block copolymer includes a hydrophobic block having a plurality of repeating units represented as chemical formula 1; and a hydrophilic block having a plurality of repeating units represented as chemical formula 2. The multi-block copolymer is acidified, and can be used to an electrolyte membrane and a fuel cell. The use of the multi-block copolymer as an electrolyte membrane ensures excellent dimensional stability.

  本发明公开了一种多嵌段共聚物、其生产方法以及使用该共聚物的电解质膜。多嵌段共聚物包括具有多个重复单元的疏水嵌段（化学式 1 表示）和具有多个重复单元的亲水嵌段（化学式 2 表示）。多嵌段共聚物经过酸化，可用于电解质膜和燃料电池。将多嵌段共聚物用作电解质膜可确保优异的尺寸稳定性。
• Palladium catalyzed cyclocarbonylation of 3,3-diarylallyl acetates
  作者：Masakazu Iwasaki、Youichi Ishii、Masanobu Hidai

  DOI：10.1016/0022-328x(91)80143-8

  日期：1991.9

  Palladium-catalyzed cyclocarbonylation of 3,3-diarylallyl acetates afforded 4-aryl-substituted 1-naphthyl acetates where the cyclization occurred selectively on the more electron-rich ring.