7,13-dihydro-2,6,7,11-tetramethyl-7,13-methanoquino[3,4-c][1]benzazepine | 32640-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 7,13-dihydro-2,6,7,11-tetramethyl-7,13-methanoquino[3,4-c][1]benzazepine
• 英文别名: 2,6,7,11-tetramethyl-8,13-dihydro-7H-7,13-methano-benzo[6,7]azepino[3,4-c]quinoline；5,10,12,17-Tetramethyl-9,13-diazapentacyclo[10.7.1.02,11.03,8.014,19]icosa-2,4,6,8,10,14(19),15,17-octaene
• CAS: 32640-23-6
• 化学式: C₂₂H₂₂N₂
• 分子量: 314.43
• InChiKey: DHIWWDGBWVCWNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2，6-二甲基喹啉 在 溶剂黄146 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以56%的产率得到5,6,7,8,13,14-hexahydro-2,6,7,11-tetramethyl-6,14:7,13-dimethanodibenzo[e,i][1,4]diazecine
  参考文献：
  名称：

  One-pot stereoselective synthesis of dimethanodibenzo[e,i][1,4]diazecines by a zinc-acetic acid promoted cascade reaction

  摘要：

  The title compounds interesting C-2 symmetrical diamines. They were prepared in a one-pot process by reacting quinaldines with a zinc-acetic acid mixture in THF solution. During this simple and stereoselective process, two C-C bonds and 4 stereogenic centres are created under mild conditions. Influence of the concentration of reagents upon yields and intramolecular cyclization regiochemistry is demonstrated. Experiments using deuteriated acetic acid allowed a good understanding of these results. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00479-2

文献信息

• One-pot stereoselective synthesis of dimethanodibenzo[e,i][1,4]diazecines by a zinc-acetic acid promoted cascade reaction
  作者：Christelle Podevin、Micheline Grignon-Dubois、Gladys Nuissier、Jean-Christophe Gauffre、Bernadette Rezzonico

  DOI：10.1016/s0040-4020(99)00479-2

  日期：1999.7

  The title compounds interesting C-2 symmetrical diamines. They were prepared in a one-pot process by reacting quinaldines with a zinc-acetic acid mixture in THF solution. During this simple and stereoselective process, two C-C bonds and 4 stereogenic centres are created under mild conditions. Influence of the concentration of reagents upon yields and intramolecular cyclization regiochemistry is demonstrated. Experiments using deuteriated acetic acid allowed a good understanding of these results. (C) 1999 Elsevier Science Ltd. All rights reserved.