9,10-Dihydrophenanthrene-2,7-dicarboxylic acid | 25401-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 9,10-Dihydrophenanthrene-2,7-dicarboxylic acid
• CAS: 25401-08-5
• 化学式: C₁₆H₁₂O₄
• 分子量: 268.26
• InChiKey: WVDLFYMZHGPTIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 9,10-dihydrophenanthrene-2,7-dicarboxylic acid diesters, 7-Bromo-9,10-dihydrophenanthrene-2-carboxylic acid esters and a process for producing the same
  申请人：Director General, Agency of Industrial Science and Technology

  公开号：EP0397418A1

  公开（公告）日：1990-11-14

  A novel 9,10-dihydrophenanthrene2,7-­dicarboxylic acid diester represented by the general formula (I): and a novel 7-bromo-9,10-dihydrophenanthrene-2-carboxylic acid monoester represented by the general formula (II): wherein each R represents a hydrocarbon group containing from 1 to 20 carbon atoms. A process for selectively synthesizing the compound of the general formula (I) and the compound of the general formula (II) comprising reacting 2,7-dibromo-9,10-dihydrophenanthrene with carbon monoxide and an alcohol of the general formula (III) R-OH in the presence of a base and a palladium-phosphine catalyst. Such novel compounds of the general formula (I) and (II) can be produced in a high yield and selectivity from inexpensive raw materials by simple reaction steps.

  一种新的9,10-二氢菲烯2,7-二羧酸二酯，其通式表示为(I)：和一种新的7-溴-9,10-二氢菲烯-2-羧酸单酯，其通式表示为(II)：其中每个R表示含有1至20个碳原子的烃基。一种选择性合成通式(I)化合物和通式(II)化合物的方法，包括在碱和钯-膦催化剂的存在下，将2,7-二溴-9,10-二氢菲烯与通式(III) R-OH的醇和一氧化碳反应。这些新的通式(I)和(II)化合物可以通过简单的反应步骤从廉价原材料中高产率和选择性地制备。
• Dna minor groove binding compounds
  申请人：Khalaf Abedawn

  公开号：US20070117760A1

  公开（公告）日：2007-05-24

  There is provided an oligopeptide compound comprising: (a) at least one nitrogen-containing basic group attached to at least one end of the oligopeptide; and (b) two or more heterocyclic monomers, at least one of which is substituted in the heterocyclic part by a branched, cyclic or part cyclic C 3-5 alkyl group, or a pharmaceutically acceptable salt or solvate thereof; which compound, salt or solvate binds to the minor groove of DNA.

  提供一种寡肽化合物，包括：（a）至少一个含氮的碱性基团连接到寡肽的至少一个末端；以及（b）两个或更多的杂环单体，其中至少一个在杂环部分被支链、环状或部分环状的C3-5烷基取代，或其药学上可接受的盐或溶剂；该化合物、盐或溶剂与DNA的小沟结合。
• DNA MINOR GROOVE BINDING COMPOUNDS
  申请人：The University of Strathclyde

  公开号：EP1467969A2

  公开（公告）日：2004-10-20
• US3931211A
  申请人：——

  公开号：US3931211A

  公开（公告）日：1976-01-06
• US7700765B2
  申请人：——

  公开号：US7700765B2

  公开（公告）日：2010-04-20