(E)-dec-7-enoic acid | 53036-81-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-dec-7-enoic acid
• 英文别名: dec-7t-enoic acid；Dec-7t-ensaeure
• CAS: 53036-81-0
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: RJWWDKCADVZWPF-ONEGZZNKSA-N

物化性质

• 沸点：
  280.2±19.0 °C(Predicted)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-dec-7-enoic acid 在 lithium aluminium tetrahydride 作用下， 生成 反式-7-癸烯醇
  参考文献：
  名称：

  Isolation of 7-Decen-1-ol from an Ascidian

  摘要：

  DOI：

  10.1021/jo01355a022
• 作为产物：
  描述：

  trans-Hepten-(4)-carbonsaeure-(1) 在 吡啶 、 lithium aluminium tetrahydride 、 乙醚 、 乙醇 、 三溴化磷 作用下， 生成 (E)-dec-7-enoic acid
  参考文献：
  名称：

  Isolation of 7-Decen-1-ol from an Ascidian

  摘要：

  DOI：

  10.1021/jo01355a022

文献信息

• [EN] 7-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME<br/>[FR] COMPOSÉS MODULATEURS DU RÉCEPTEUR DES OPIOÏDES DELTA CONTENANT DES HÉTÉROCYCLES AZA À 7 CHAÎNONS, ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：TREVENA INC

  公开号：WO2018152286A1

  公开（公告）日：2018-08-23

  The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

  本实施例部分涉及化合物、其药用盐，或用于调节δ阿片受体活性的药物组合物，包括有偏倚和/或无偏倚的组合物，以及用于治疗疼痛、偏头痛、头痛、抑郁症、帕金森病、焦虑症、过度活跃膀胱以及其他在本文中描述的紊乱和症状的方法，或其中的任何组合。
• Sequential Alkene Isomerization and Ring‐Closing Metathesis in Production of Macrocyclic Musks from Biomass
  作者：Adrian Sytniczuk、Gwénaël Forcher、Douglas B. Grotjahn、Karol Grela

  DOI：10.1002/chem.201800728

  日期：2018.7.20

  We report successful utilization of sequential alkene isomerization and ring‐closing metathesis of dec‐9‐enoic acid based dienes in synthesis of macrocyclic lactones that possess a strong scent of musk. This catalytic sequence was essential to trim the chain length of starting dienes to yield macrocycles of the right size. Dec‐9‐enoic acid is conveniently obtainable from oleic esters by Ru‐catalysed

  我们报道了在具有强烈麝香气息的大环内酯的合成中成功利用顺序的烯烃异构化和基于dec-9烯酸的二烯闭环易位。该催化序列对于修整起始二烯的链长以产生合适尺寸的大环是必不可少的。可通过Ru催化的乙烯分解从油酸酯中方便地获得Dec-9-烯酸。
• Glycitan Esters of Unsaturated Fatty Acids and Their Preparation
  申请人：Elevance Renewable Sciences, Inc.

  公开号：US20150307469A1

  公开（公告）日：2015-10-29

  A method is disclosed for making an unsaturated glycitan ester by reacting intramolecular condensates of glycitols having four or more carbons with a metathesis-derived unsaturated fatty acid in the presence of an alkaline catalyst and under conditions sufficient to form the aforesaid unsaturated glycitan fatty ester. A composition is also disclosed comprising a compound of the following structure: wherein R 1 is hydrogen, alkyl, aryl or (CH 2 ) 1-9 —COOR 5 ; wherein R 5 is wherein R 2 , R 3 and R 4 are hydrogen, or —(O)C—(CH 2 ) m —CH═CH—R 1 or —(CH 2 CH 2 O) n H or mixtures thereof; wherein m is 1 to 9; and wherein n is 1 to 100.

  本方法涉及通过在碱性催化剂存在下，在足够条件下与来自交换反应的不饱和脂肪酸反应的具有四个或更多碳的甘露醇的分子内缩合物反应，制备不饱和的甘露醇脂肪酸酯。本发明还涉及一种化合物，其结构如下：其中R1为氢、烷基、芳基或(CH2)1-9—COOR5；其中R5为其中R2、R3和R4为氢，或—(O)C—(CH2)m—CH═CH—R1或—(CH2CH2O)nH或它们的混合物；其中m为1至9；其中n为1至100。
• METHODS OF MAKING ORGANIC COMPOUNDS BY METATHESIS
  申请人：Elevance Renewable Sciences, Inc.

  公开号：EP3281931A1

  公开（公告）日：2018-02-14

  Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

  本发明描述了通过偏合成化学制造有机化合物的方法。本发明的方法特别适用于从可再生原料（如天然油）中提取的起始组合物开始制造工业上重要的有机化合物。这些方法利用与烯烃化合物的交叉甲基化步骤，生成具有预定双键位置的官能化烯中间体。一旦分离出来，官能化烯中间体可进行自甲基化或交叉甲基化（例如与第二种官能化烯），以生产所需的有机化合物或其前体。该方法可用于制造双官能团有机化合物，如二酸、二酯、二羧酸盐、酸/酯、酸/胺、酸/醇、酸/醛、酸/酮、酸/卤化物、酸/腈、酯/胺、酯/醇、酯/醛、酯/酮、酯/卤化物、酯/腈等。
• Methods of making organic compounds by metathesis
  申请人：Wilmar Trading Pte Ltd

  公开号：US10906861B2

  公开（公告）日：2021-02-02

  Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

  本发明描述了通过偏合成化学制造有机化合物的方法。本发明的方法特别适用于从可再生原料（如天然油）中提取的起始组合物开始制造工业上重要的有机化合物。这些方法利用与烯烃化合物的交叉甲基化步骤，生成具有预定双键位置的官能化烯中间体。一旦分离出来，官能化烯中间体可进行自甲基化或交叉甲基化（例如与第二种官能化烯），以生产所需的有机化合物或其前体。该方法可用于制造双官能团有机化合物，如二酸、二酯、二羧酸盐、酸/酯、酸/胺、酸/醇、酸/醛、酸/酮、酸/卤化物、酸/腈、酯/胺、酯/醇、酯/醛、酯/酮、酯/卤化物、酯/腈等。