N,N'-Bis-chloracetyl-o-diansidin | 2810-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-chloracetyl-o-diansidin
• 英文别名: N,N'-(3,3'-dimethoxybiphenyl-4,4'-diyl)bis(2-chloroacetamide)；4,4'-bis-(2-chloro-acetylamino)-3,3'-dimethoxy-biphenyl；4,4'-Bis-(2-chlor-acetylamino)-3,3'-dimethoxy-biphenyl；2-Chloro-N-[4'-(2-chloro-acetylamino)-3,3'-dimethoxy-biphenyl-4-yl]-acetamide；2-chloro-N-[4-[4-[(2-chloroacetyl)amino]-3-methoxyphenyl]-2-methoxyphenyl]acetamide
• CAS: 2810-43-7
• 化学式: C₁₈H₁₈Cl₂N₂O₄
• mdl: MFCD00490826
• 分子量: 397.258
• InChiKey: SWEQGDSFYRJSIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,N'-Bis-chloracetyl-o-diansidin 在 三氯化铝 、 氯苯 作用下， 生成 bis-lactam <7,7'-bi-2H-1,4-benzoxazine>-3(4H),3'(4'H)-dione
  参考文献：
  名称：

  Process for the production of alpha-(o-aminoaryloxy)-fatty acids or their salts

  摘要：

  公开号：

  US02724722A1
• 作为产物：
  描述：

  monochloroacetic acid anhydride 、 联大茴香胺 以 1,2-二氯乙烷 为溶剂， 生成 N,N'-Bis-chloracetyl-o-diansidin
  参考文献：
  名称：

  Svetkin,Yu.V., Journal of general chemistry of the USSR, 1965, vol. 35, # 5, p. 837 - 839

  摘要：

  DOI：

文献信息

• Sen Gupta et al., Journal of the Indian Chemical Society, 1957, vol. 34, p. 71
  作者：Sen Gupta et al.

  DOI：——

  日期：——
• Process for the production of alpha-(o-aminoaryloxy)-fatty acids or their salts
  申请人：GEIGY AG J R

  公开号：US02724722A1

  公开（公告）日：1955-11-22
• In Vitro Imaging and Human Serum Albumin Responsive Dimeric Lanthanide DO3A Complex
  作者：Yuen On Fung、Wanqing Wu、Chi-Tung Yeung、Hoi-Kuan Kong、Kenny Kam-Cheng Wong、Wai-Sum Lo、Ga-Lai Law、Ka-Leung Wong、Chi-Kong Lau、Chi-Sing Lee、Wing-Tak Wong

  DOI：10.1021/ic2004672

  日期：2011.6.20

  Two series of dimeric DO3A (1,4,7,10-tetraazacyclodecane-1,4,7-triacetate) lanthanide complexes (LnL(1)-LnL(2), Ln = Eu, Gd, and Tb) have been synthesized with two different bridged chromophores. The X-ray structures of dimeric LnL(1) (Ln = Gd and Tb) complexes show that each metal ion has nine coordination numbers with eight directly bound donor atoms of the ligand and one oxygen donor from the water molecule. Photophysical measurements indicate that the bridged antenna in LnL(2) gives a higher efficiency than that of LnL(1) and is responsive to the protein Human Serum Albumin (HSA), giving an f-f luminescence signal enhancement with a binding constant log K = 4.84. In vitro imaging of EuL(1) and EuL(2) in HeLa cells has been recorded, and EuL(2) has demonstrated a higher rate of cellular uptake and low cytotoxicity (IC(50) = 3 mM).
• Gheorghe; Schell, 1958, vol. 1, p. 247,251
  作者：Gheorghe、Schell

  DOI：——

  日期：——
• Gheorghe; Schell, 1958, vol. 1, p. 247,253
  作者：Gheorghe、Schell

  DOI：——

  日期：——