1-(2-(benzyloxy)ethyl)-2-methoxybenzene | 1408140-99-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-(benzyloxy)ethyl)-2-methoxybenzene
• 英文别名: 1-Methoxy-2-(2-phenylmethoxyethyl)benzene
• CAS: 1408140-99-7
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: YTJGTSHVXDXKMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苄基2-溴乙基醚 在 copper(l) iodide 、 二氯双[二叔丁基-(4-二甲基氨基苯基)膦]钯(II) 、 lithium methanolate 、 caesium carbonate 作用下， 以 四氢呋喃 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 46.0h， 生成 1-(2-(benzyloxy)ethyl)-2-methoxybenzene
  参考文献：
  名称：

  Suzuki–Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs

  摘要：

  The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.

  DOI：

  10.1021/jo3021665

文献信息

• Pharmaceutical compositions of diaryl-isoxazole derivatives for the prevention and treatment of cancers
  申请人：Kwon Byoung-Mog

  公开号：US20050131036A1

  公开（公告）日：2005-06-16

  The present invention relates to a pharmaceutical composition for the prevention and the treatment of cancers containing diaryl-isoxazole derivatives as an effective ingredient. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.

  本发明涉及一种包含二芳基异噁唑衍生物作为有效成分的用于预防和治疗癌症的药物组合物。本发明的二芳基异噁唑衍生物抑制乳腺癌细胞系的转移和血管生成，因此可以作为转移抑制剂生产，并进一步作为预防和治疗与血管生成相关疾病的药物组合物，包括癌症、类风湿性关节炎、牛皮癣或眼球内引起的血管生成疾病等。
• US7250432B2
  申请人：——

  公开号：US7250432B2

  公开（公告）日：2007-07-31
• [EN] NEW DIARYL-ISOXAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME FOR THE PREVENTION AND THE TREATMENT OF CANCERS<br/>[FR] NOUVEAUX DERIVES DIARYL-ISOXAZOLE AINSI QUE COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERIVES POUR LA PREVENTION ET LE TRAITEMENT DE CANCERS
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2006126751A1

  公开（公告）日：2006-11-30

  [EN] The present invention relates to new diaryl-isoxazole derivatives, and pharmaceutical compositions containing the same as an effective ingredient for the prevention and the treatment of cancers. Diaryl-isoxazole derivatives of the present invention inhibit metastasis of breast cancer cell lines and angiogenesis, so that they can be produced as a metastasis inhibitor and further as a pharmaceutical composition for the prevention and the treatment of angiogenesis related diseases including cancers, rheumatoid arthritis, psoriasis, or angiogenesis diseases caused in eyeball, etc.
  [FR] L'invention concerne de nouveaux dérivés diaryl-isoxazole ainsi que des compositions pharmaceutiques contenant ces dérivés en tant qu'ingrédient efficace pour la prévention et le traitement de cancers. Les dérivés diaryl-isoxazole de cette invention inhibent les métastases de lignées cellulaires du cancer du sein ainsi que l'angiogenèse. Ainsi, ils peuvent être produits en tant qu'inhibiteurs de métastase et également en tant que composition pharmaceutique pour la prévention et le traitement de maladies liées à l'angiogenèse, notamment les cancers, le polyarthrite rhumatoïde, le psoriasis, ou des maladies d'angiogenèse provoquées dans le globe oculaire, etc.
• Suzuki–Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs
  作者：Nicolas Fleury-Brégeot、Marc Presset、Floriane Beaumard、Virginie Colombel、Daniel Oehlrich、Frederik Rombouts、Gary A. Molander

  DOI：10.1021/jo3021665

  日期：2012.11.16

  The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.