N-carbamoyl-anthranilic acid amide | 30932-74-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-carbamoyl-anthranilic acid amide
• 英文别名: N-Carbamoyl-anthranilsaeure-amid；(2-Carbamoyl-phenyl)-harnstoff；(2-Carbaminyl-phenyl)-harnstoff；2-Ureido-benzamid；2-Ureidobenzamid；2-Ureidobenzamide；2-(carbamoylamino)benzamide
• CAS: 30932-74-2
• 化学式: C₈H₉N₃O₂
• 分子量: 179.178
• InChiKey: CXGQKYNRBWUOMP-UHFFFAOYSA-N

物化性质

• 熔点：
  >280 °C
• 沸点：
  371.7±25.0 °C(Predicted)
• 密度：
  1.395±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-carbamoyl-anthranilic acid amide 生成 2,4-喹唑啉二酮
  参考文献：
  名称：

  Jacini, Gazzetta Chimica Italiana, 1942, vol. 72, p. 510,514

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ammonium hydroxide 、 双氧水 作用下， 生成 N-carbamoyl-anthranilic acid amide
  参考文献：
  名称：

  Jacini, Gazzetta Chimica Italiana, 1942, vol. 72, p. 510,514

  摘要：

  DOI：

文献信息

• [EN] NOVEL BENZAMIDE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS<br/>[FR] NOUVEAUX COMPOSES DE BENZAMIDE DESTINES A ETRE UTILISES DANS DES TROUBLES ASSOCIES AU RECEPTEUR DE MCH
  申请人：7TM PHARMA AS

  公开号：WO2004048319A1

  公开（公告）日：2004-06-10

  Novel compounds of Formula I which modulate MCH activity are disclosed, in which A is a linker, Ar, is an aryl or heteroaryl group; R1 is hydrogen or a lower alkoxy group; Q together with the carbonyl forms an amide group, which is further substituted with an amine group; R5 is hydrogen, halogen atoms, alkoxy groups, hydroxy, alkylamino groups, dialkylamino groups, hydroxylalkyl groups, carboxamido groups, acylamido groups, acyl groups, -CHO, nitrile, alkyl, alkenyl or alkynyl groups, -SCH3, partially or fully fluorinated alkyl, alkoxy or thioalkoxy groups such as -CH2CF3, -CF2CF3, -CF3, -OCF3, -SCF3; -SO2NH2, -SO2NHAlk, -SO2NAlk2, -SO2AIk; R8 is hydrogen, halogen atoms, alkyl, alkenyl or alkynyl groups, cycloalkyl groups, alkylcycloalkyl groups, alkoxy groups, dialkylamino groups, -CONHAIk, -CONAIk2, - NHCO-Alk, -CO-Alk, -SCH3, partially or fully fluorinated alkyl, alkoxy or thioalkoxy groups such as -CH2CF3, -CF2CF3, -CF3, -OCF3, -SCF3; X is H, F, Cl, Br, I, -SCH3, partially or fully fluorinated alkyl, alkoxy or thioalkoxy groups such as -CH2CF3, - CF2CF3, -CF3, -OCF3, -SCF3; OCH3 or lower alkyl or alkenyl group; and which are useful in the treatment or prevention of e.g. obesity, depression, diabetes, bulimia etc.

  公开了调节MCH活性的Formula I的新化合物，其中A是连接剂，Ar是芳基或杂环芳基；R1是氢或较低的烷氧基；Q与羰基一起形成酰胺基团，该基团进一步被氨基取代；R5是氢、卤素原子、烷氧基、羟基、烷基氨基基团、二烷基氨基基团、羟基烷基基团、羧酰胺基团、酰胺基团、酰基、-CHO、腈基、烷基、烯基或炔基、-SCH3、部分或完全氟代烷基、烷氧基或硫代烷氧基基团，如-CH2CF3、-CF2CF3、-CF3、-OCF3、-SCF3；-SO2NH2、-SO2NHAlk、-SO2NAlk2、-SO2AIk；R8是氢、卤素原子、烷基、烯基或炔基、环烷基、烷基环烷基、烷氧基、二烷基氨基基团、-CONHAIk、-CONAIk2、-NHCO-Alk、-CO-Alk、-SCH3、部分或完全氟代烷基、烷氧基或硫代烷氧基基团，如-CH2CF3、-CF2CF3、-CF3、-OCF3、-SCF3；X是H、F、Cl、Br、I、-SCH3、部分或完全氟代烷基、烷氧基或硫代烷氧基基团，如-CH2CF3、-CF2CF3、-CF3、-OCF3、-SCF3；OCH3或较低的烷基或烯基基团；这些化合物在治疗或预防肥胖、抑郁症、糖尿病、暴食症等方面是有用的。
• N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
  申请人：——

  公开号：US20030119811A1

  公开（公告）日：2003-06-26

  Compounds represented by Formula (I): 1 or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.

  由化学式(I)代表的化合物或其药用盐，可作为NMDA NR2B拮抗剂，用于缓解疼痛。
• 2-Ureido-benzamide derivatives
  申请人：GRELAN PHARMACEUTICAL CO., LTD.

  公开号：EP0742208A1

  公开（公告）日：1996-11-13

  This invention relates to 2-ureido-benzamide compounds of the formula : in which R1 is H, halogen atom, (C1-C4)alkyl, (C1-C4)alkoxy or (C1-C4)dialkylamino and R2 is H, halogen atom, hydroxy, nitro, (C1-C4)alkyl, (C1-C4)alkoxy or -(CH2)jNR3R3, wherein j is an integer of from 0 to 2, R3 and R4 are each independently H, (C1-C4)alkyl, (C1-C4)alkylsulfonyl or (C1-C4)alkylcarbamoyl, or R3 and R4 taken together with the N-atom to which they are linked can form a pyrrolidine, piperidine, morpholine, imidazole or pyrazole ring ; X is a (C3-C15)alkyl or -(CH2)kNR5R6 group, wherein k is an integer of from 1 to 4 and R5 and R6 are each independently H, (C1-C6)alkyl or (C1-C4)alkoxycarbonyl ; and, Y is H or (C1-C4)alkyl and Z is or -(CH2)m―A2 wherein m is an integer of from 0 to 4, Q is -CH2- or -CH2CH2-, A1 is phenyl, benzyl, diphenylmethyl, pyridyl, imidazolyl, imidazolythio, dibenzoxepinyl or phenoxycarbonyl optionally carrying halogen atom, hydroxy, (C1-C7)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxymethyl, phenyl or halogenophenyl, A2 is phenyl, benzyl, diphenylmethyl, imidazolylthio, dibenzoxepinyl or phenoxycarbonyl optionally carrying halogen atom, hydroxy, (C1-C7)alkyl, (C1-C4)alkoxy, (C1-C4)alkoxymethyl, phenyl or halogenophenyl, R7 is H or (C1-C4)alkyl and R8 is (C1-C4)alkyl, or R7 and R8 taken together with the C-atom to which they are linked can form a cyclopentyl, cyclohexyl or cycloheptyl ring ; or, Y and Z taken together with the N-atom to which they are linked can form a ring wherein n is an integer of from 1 to 3 and B is phenyl, diphenylmethyl or dibenzocycloheptenyl optionally carrying halogen atom or (C1-C4)alkoxy ; and pharmaceutically acceptable acid addition salts thereof. Those compounds are useful as acyl-CoA:cholesterol acyltransferase inhibitors.

  本发明涉及式.的 2-脲基苯甲酰胺化合物： 其中 R1 是 H、卤素原子、(C1-C4)烷基、(C1-C4)烷氧基或 (C1-C4)二烷基氨基，R2 是 H、卤素原子、羟基、硝基、(C1-C4)烷基、(C1-C4)烷氧基或 -(CH2)jNR3R3，其中 j 是 0 至 2 的整数、R3 和 R4 各自独立地为 H、(C1-C4)烷基、(C1-C4)烷基磺酰基或(C1-C4)烷基氨基甲酰基，或 R3 和 R4 与它们连接的 N 原子一起可形成吡咯烷、哌啶、吗啉、咪唑或吡唑环； X 是(C3-C15)烷基或-(CH2)kNR5R6 基团，其中 k 是 1 至 4 的整数，R5 和 R6 各自独立地是 H、(C1-C6)烷基或(C1-C4)烷氧羰基；以及 Y 是 H 或 (C1-C4) 烷基，Z 是 或-(CH2)m-A2 其中，m 是 0 至 4 的整数，Q 是-CH2-或-CH2CH2-，A1 是苯基、苄基、二苯甲基、吡啶基、咪唑基、咪唑硫基、二苯并氧杂环庚基或苯氧羰基，可选择带有卤素原子、羟基、(C1-C7)烷基、(C1-C4)烷氧基、(C1-C4)烷氧基甲基、苯基或卤素苯基，A2 是苯基、苄基、二苯甲基、咪唑硫基、二苯并氧杂环庚基或苯氧羰基、R7 是 H 或 (C1-C4)烷基，R8 是 (C1-C4)烷基，或 R7 和 R8 与它们连接的 C 原子一起可形成环戊基、环己基或环庚基环；或 Y 和 Z 与它们连接的 N 原子一起可形成一个环 其中 n 为 1 至 3 的整数，B 为苯基、二苯甲基或二苯并环庚烯基，可选择携带卤素原子或（C1-C4）烷氧基；及其药学上可接受的酸加成盐。 这些化合物可用作酰基-CoA：胆固醇酰基转移酶抑制剂。
• Jacobs; Heidelberger, Journal of the American Chemical Society, 1917, vol. 39, p. 2437
  作者：Jacobs、Heidelberger

  DOI：——

  日期：——
• Kuehle; Wegler, Justus Liebigs Annalen der Chemie, 1958, vol. 616, p. 183,206
  作者：Kuehle、Wegler

  DOI：——

  日期：——