N-sec-butylsuccinimide | 74295-62-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-sec-butylsuccinimide
• 英文别名: 1-sec-butylpyrrolidine-2,5-dione；N-sec-Butyl-succinimid；N-2-Butylsuccinimide；1-(Butan-2-yl)pyrrolidine-2,5-dione；1-butan-2-ylpyrrolidine-2,5-dione
• CAS: 74295-62-8
• 化学式: C₈H₁₃NO₂
• 分子量: 155.197
• InChiKey: YHIRZURYLALOEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-sec-butylsuccinimide 在 sodium tetrahydroborate 、 三氟化硼乙醚 作用下， 以 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 生成 1-sec-butyl-5-(1H-indol-3-yl)pyrrolidin-2-one
  参考文献：
  名称：

  Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2-ones from available reagents

  摘要：

  The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.

  DOI：

  10.1007/s10593-011-0655-x
• 作为产物：
  描述：

  N-sec-butylsuccinamic acid 在 溶剂黄146 、 三乙胺 作用下， 以 苯 为溶剂， 反应 24.0h， 以95%的产率得到N-sec-butylsuccinimide
  参考文献：
  名称：

  Regioselective synthesis of 1-alkyl-5-(indol-3-yl- and -2-yl)pyrrolidin-2-ones from available reagents

  摘要：

  The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones.

  DOI：

  10.1007/s10593-011-0655-x

文献信息

• [EN] PROCESSES FOR MAKING, AND METHODS OF USING, GLYCOPYRRONIUM COMPOUNDS<br/>[FR] PROCÉDÉS DE FABRICATION ET PROCÉDÉS D'UTILISATION DE COMPOSÉS GLYCOPYRRONIUM
  申请人：DERMIRA INC

  公开号：WO2018026869A1

  公开（公告）日：2018-02-08

  Provided herein are processes for making and methods of using salts of glycopyrronium, including solid forms and forms suitable for use as topicals. Disclosed here are processes for making salts of glycopyrronium, also processes for making compositions comprising salts of glycopyrronium, and methods of treating hyperhidrosis with salts of glycopyrronium as well as with compositions comprising salts of glycopyrronium such as, but not limited to, topical compositions. Disclosed herein are methods of treating hyperhidrosis including administering salts of glycopyrronium to subjects in need thereof.

  本文提供了制备和使用格隆铵盐的方法，包括固体形式和适合用作局部药物的形式。本文披露了制备格隆铵盐的方法，还包括制备含有格隆铵盐的组合物的方法，以及使用格隆铵盐治疗多汗症的方法，以及使用含有格隆铵盐的组合物治疗多汗症的方法，例如但不限于局部组合物。本文披露了治疗多汗症的方法，包括向需要的受试者施用格隆铵盐。
• Versatile and Sustainable Synthesis of Cyclic Imides from Dicarboxylic Acids and Amines by Nb₂O₅as a Base-Tolerant Heterogeneous Lewis Acid Catalyst
  作者：Md. Ayub Ali、S. M. A. Hakim Siddiki、Kenichi Kon、Junya Hasegawa、Ken-ichi Shimizu

  DOI：10.1002/chem.201404538

  日期：2014.10.27

  Catalytic condensation of dicarboxylics acid and amines without excess amount of activating reagents is the most atom‐efficient but unprecedented synthetic method of cyclic imides. Here we present the first general catalytic method, proceeding selectively and efficiently in the presence of a commercial Nb2O5 as a reusable and base‐tolerant heterogeneous Lewis acid catalyst. The method is effective for

  二羧酸和胺的催化缩合反应没有过量的活化剂是最高效，最空前的环状酰亚胺合成方法。在这里，我们介绍了第一种通用催化方法，该方法在作为可重用和耐碱多相路易斯酸催化剂的商业Nb 2 O 5的存在下选择性而有效地进行。该方法可有效地从二羧酸或酸酐与胺，羟胺或氨直接合成药学上或工业上重要的环状酰亚胺，例如苯甲酰亚胺，N-羟基邻苯二甲酰亚胺（NHPI）和未取代的环状酰亚胺。
• [EN] HETEROCYCLIC SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SUBSTITUES PAR DES HETEROCYCLES, UTILISES COMME ANTAGONISTES DES RECEPTEURS 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005003124A1

  公开（公告）日：2005-01-13

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括这些新化合物的药用组合物以及这些化合物作为药物的用途。
• METHOD FOR STEREOSELECTIVELY PRODUCING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：EP3693373A1

  公开（公告）日：2020-08-12

  The present invention provides industrially suitable processes for preparing intermediates in the production of substituted polycyclic pyridone derivatives having a cap-dependent endonuclease inhibitory activity. In the process as shown below, wherein each symbol is as defined in the specification, an optically active substituted tricyclic pyridone derivative of the formula (VII) is obtained in high yield and high enantioselectivity by subjecting a compound of the formula (III) or (VI) to intramolecular cyclization with controlling stereochemistry to obtain a compound of the formula (IV) having a removable functional group on an asymmetric carbon, and then removing the functional group thereof.

  本发明提供了适合工业化生产的工艺，用于制备具有帽依赖性内切酶抑制活性的取代多环吡啶酮衍生物的中间体。 在下图所示的工艺中（其中各符号如说明书中所定义），通过将式（III）或（VI）化合物进行立体化学控制的分子内环化，以获得在不对称碳上具有可去除官能团的式(IV)化合物，然后去除其官能团，从而以高产率和高对映选择性获得光学活性的式(VII)取代的三环吡啶酮衍生物。
• LINKER, ANTIBODY-DRUG CONJUGATE INCLUDING SAME, AND USE THEREOF
  申请人：Academy of Military Medical Sciences

  公开号：EP3838893A1

  公开（公告）日：2021-06-23

  Provided are a linker represented by Formula I or I', an antibody-drug conjugate containing the same, and use of thereof, a pharmaceutical composition comprising the antibody-drug conjugate, and use of the antibody-drug conjugate for treating and/or preventing a disease.

  本文提供了一种由式 I 或式 I'表示的连接体、一种含有该连接体的抗体-药物共轭物及其用途、一种含有该抗体-药物共轭物的药物组合物，以及该抗体-药物共轭物在治疗和/或预防疾病方面的用途。