3-Boc-amino-1,2-propanediol | 1378293-39-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-Boc-amino-1,2-propanediol
• 英文别名: Tert-butyl 2-amino-3,4-dihydroxybutanoate；tert-butyl 2-amino-3,4-dihydroxybutanoate
• CAS: 1378293-39-0
• 化学式: C₈H₁₇NO₄
• 分子量: 191.227
• InChiKey: UUAQQFAGTKHSCE-UHFFFAOYSA-N

物化性质

• 沸点：
  334.9±42.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  potassium metaperiodate 、 3-Boc-amino-1,2-propanediol 、 3-氨基-1,2-丙二醇 、 二碳酸二叔丁酯 在 盐酸 、 sodium hydroxide 作用下， 以 水 、 乙酸乙酯 为溶剂， 生成 N-叔丁氧羰基-2-氨基乙醛
  参考文献：
  名称：

  Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

  摘要：

  一种被称为肽核酸的新型化合物类别，能够结合互补的DNA和RNA链，通常比相应的DNA或RNA链结合更牢固，同时表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和非天然存在的核碱基（包括2,6-二氨基嘌呤）中选择的配体，这些配体连接在聚酰胺骨架上，并含有烷基胺侧链。

  公开号：

  US06710164B1

文献信息

• Peptide nucleic acids having 2,6-diaminopurine nucleobases
  申请人：——

  公开号：US06414112B1

  公开（公告）日：2002-07-02

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

  一种新型化合物类别，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和结合亲和力。该发明的肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然核碱基中选择的配体。该发明的一些肽核酸还包含C1-C8烷基胺侧链。
• Peptide nucleic acids having enhanced binding affinity, sequence
  申请人：——

  公开号：US05714331A1

  公开（公告）日：1998-02-03

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.

  一种新型化合物，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然存在的核碱基中选择的配体，并含有C.sub.1 -C.sub.8烷基胺侧链。提供了增强PNAs溶解性、结合亲和力和序列特异性的方法。
• Peptide nucleic acids having amino acid side chains
  申请人：——

  公开号：US05719262A1

  公开（公告）日：1998-02-17

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.

  一种新型化合物，被称为肽核酸，比相应的DNA或RNA链更强烈地结合互补的DNA和RNA链，并表现出增强的序列特异性和溶解性。肽核酸包括从一组中选择的配体，该组包括天然存在的核碱基和连接到聚酰胺骨架的非天然存在的核碱基，并含有烷基胺侧链。
• Polyamide oligomers
  申请人：——

  公开号：US20020026027A1

  公开（公告）日：2002-02-28

  The present invention relates to new polyamide oligomers. These oligomers can be conjugated to lipids, nucleic acids, peptides, proteins, etc. The oligomer-lipid conjugates can be used to form liposomes, virusomes, micelles, etc., optionally containing drugs or biological agents. The polyamide oligomers are heterobifunctional allowing the attachment of other suitable ligand compounds (e.g., a targeting moiety). In addition, methods of use for the liposomes, virusomes, micelles, etc., are provided.

  本发明涉及新的聚酰胺寡聚体。这些寡聚体可以与脂质、核酸、肽、蛋白质等共轭。寡聚体-脂质共轭物可以用于形成脂质体、病毒体、胶束等，可选地含有药物或生物制剂。聚酰胺寡聚体是异双官能团的，可以连接其他适当的配体化合物（例如，靶向基团）。此外，还提供了脂质体、病毒体、胶束等的使用方法。
• Coordinative alignment of molecules in chiral metal-organic frameworks
  申请人：The Regents of the University of California

  公开号：US10766911B2

  公开（公告）日：2020-09-08

  Coordinative alignment uses x-ray diffraction to precisely and unambiguously determine the structure of molecules bound or crystallized within chiral metal organic frameworks.

  协调配准利用 X 射线衍射来精确无误地确定手性金属有机框架内结合或结晶的分子结构。