phenyl phosphonomorpholinylamidochloridothioate | 73577-36-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: phenyl phosphonomorpholinylamidochloridothioate
• 英文别名: morpholin-4-yl-phenyl-phosphinothioic acid chloride；Phosphinothioic chloride, (4-morpholinyl)phenyl-；chloro-morpholin-4-yl-phenyl-sulfanylidene-λ5-phosphane
• CAS: 73577-36-3
• 化学式: C₁₀H₁₃ClNOPS
• 分子量: 261.712
• InChiKey: OEGVXAZJVLECME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl phosphonomorpholinylamidochloridothioate 、 氢氧化钾 、 盐酸 生成 phenylphosphonothioic acid
  参考文献：
  名称：

  ALMASI L.; FENESAN I.; BIRO V., J. PRAKT. CHEM., 1979, 321, NO 6, 913-920

  摘要：

  DOI：
• 作为产物：
  描述：

  吗啉 、 苯基硫代膦酰二氯 在 三乙胺 作用下， 以 乙醚 为溶剂， 生成 phenyl phosphonomorpholinylamidochloridothioate
  参考文献：
  名称：

  Almasi,L. et al., Journal fur praktische Chemie (Leipzig 1954), 1979, vol. 321, # 6, p. 913 - 920

  摘要：

  DOI：

文献信息

• MORPHOLIN-4-IUM 4 METHOXYPHENYL (MORPHOLINO) PHOSPHINODITHIOATE (GYY4137) AS A NOVEL VASODILATOR AGENT
  申请人：Moore Philip Keith

  公开号：US20100273743A1

  公开（公告）日：2010-10-28

  The invention is directed to a method of administering hydrogen sulfide (H 2 S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

  本发明涉及一种缓慢、持续地给予需要氢硫化物（H2S）的个体的方法，包括给予下列结构式所表示的化合物的有效量，或其药学上可接受的盐：
• US8541396B2
  申请人：——

  公开号：US8541396B2

  公开（公告）日：2013-09-24
• US8865684B2
  申请人：——

  公开号：US8865684B2

  公开（公告）日：2014-10-21
• [EN] A SLOW-RELEASING HYDROGEN SULPHIDE DONOR IN A METHOD FOR THE TREATMENT OF CANCER<br/>[FR] DONNEUR DE SULFURE D'HYDROGÈNE À LIBÉRATION LENTE DANS UN PROCÉDÉ DE TRAITEMENT ANTICANCÉREUX
  申请人：UNIV SINGAPORE

  公开号：WO2012154126A1

  公开（公告）日：2012-11-15

  The invention is directed to a method of treating cancer in an individual in need thereof comprising administering an effective amount of a slow-releasing H2S compound. In another aspect, the invention is directed to a method (e.g., in vitro; in vivo) of killing and/or inhibiting (e.g., selectively killing and/or inhibiting) the growth (proliferation) of a (one or more) cancer cell(s) comprising contacting cells which comprise cancer cells (e.g., a heterogeneous population of cells) with an effective amount of a slow-releasing H2S compound. A combination is thereby produced and the combination is maintained under conditions in which H2S is slowly released in the presence of the cells, thereby killing and/or inhibiting the growth of the cancer cells.