α-dimethylamino-isobutyric acid methyl ester | 140653-59-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-dimethylamino-isobutyric acid methyl ester
• 英文别名: α-Dimethylamino-isobuttersaeure-methylester；Methyl 2-(dimethylamino)-2-methylpropanoate
• CAS: 140653-59-4
• 化学式: C₇H₁₅NO₂
• mdl: MFCD13881921
• 分子量: 145.202
• InChiKey: LYRCQLASMUAFIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 N,n,2-三甲基丙氨酸 在 盐酸 作用下， 生成 α-dimethylamino-isobutyric acid methyl ester
  参考文献：
  名称：

  Clarke; Gillespie; Weisshaus, Journal of the American Chemical Society, 1933, vol. 55, p. 4576

  摘要：

  DOI：

文献信息

• CATALYTIC SYSTEM FOR CROSS-COUPLING REACTIONS
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

  公开号：US20160130205A1

  公开（公告）日：2016-05-12

  The present invention concerns a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.

  本发明涉及一种通过使带有离去基团的化合物与带有可以替代离去基团的碳原子或杂原子（HE）的亲核化合物反应，从而形成碳-碳键（C—C）或碳-杂原子键（C—HE）的过程，其中反应在存在有效量的a.包含配体和至少基于金属的催化剂的催化系统的条件下进行，这样的金属催化剂是从铁或铜化合物中选择出来的，前提是只存在单一金属。
• New Catalytic System for Cross-Coupling Reactions
  申请人：Taillefer Marc

  公开号：US20110306782A1

  公开（公告）日：2011-12-15

  The present invention concerns a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C-HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C-HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.

  本发明涉及一种通过使带有离去基团的化合物与带有可以替代离去基团的碳原子或杂原子（HE）的亲核化合物反应，从而形成碳-碳键（C—C）或碳-杂原子键（C-HE）的过程，其中反应在存在有效量的a.由配体和至少一种基于金属的催化剂组成的催化系统的条件下进行，所述金属催化剂选自铁或铜化合物，但需注意只存在单一金属。
• METHOD FOR THE PREPARATION OF PHOSPHINE BUTADIENE LIGANDS, COMPLEXES THEREOF WITH COPPER AND USE THEREOF IN CATALYSIS
  申请人：Taillefer Marc

  公开号：US20100121076A1

  公开（公告）日：2010-05-13

  The present invention relates to a method for preparing phosphine butadiene-type ligands, and their use, particularly as catalytic metal ligands used in the reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds.

  本发明涉及一种制备膦丁二烯型配体的方法及其用途，特别是作为催化金属配体用于反应中生成碳-碳和碳-杂原子键。
• USE OF CYCLOVINYL PHOSPHINE/COPPER COMPLEXES AS ARYLATION CATALYSTS
  申请人：Taillefer Marc

  公开号：US20100298569A1

  公开（公告）日：2010-11-25

  The invention relates to the use of cyclovinyl phosphine compounds in the form of complexes with copper, as catalysts for reactions leading to the formation of carbon-carbon and carbon-heteroatom bonds. The invention also relates to complexes of copper with at least one cyclovinyl phosphine, as well as to the method for creating a carbon-carbon or a carbon-heteroatom bond catalysed by a cyclovinyl phosphine/copper complex.

  本发明涉及使用与铜形成配合物的环戊烯基膦化合物作为催化剂，用于导致形成碳-碳和碳-杂原子键的反应。本发明还涉及铜与至少一种环戊烯基膦的配合物，以及由环戊烯基膦/铜配合物催化的创建碳-碳或碳-杂原子键的方法。
• Iron-Copper Co-Catalyzed Process for Carbon-Carbon or Carbon-Heteroatom Bonding
  申请人：Taillefer Marc

  公开号：US20090326240A1

  公开（公告）日：2009-12-31

  The present invention relates to a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a catalytic system comprising iron and copper.

  本发明涉及一种通过将带有离去基团的化合物与带有可替代该离去基团的碳原子或杂原子（HE）的亲核化合物反应，创建一个C-C或C-HE键的过程，其中反应在存在有效量的铁和铜催化体系的情况下进行。