N,N′-(2-hydroxypropane-1,3-diyl)bis(5-hydroxypentanamide) | 220648-39-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N′-(2-hydroxypropane-1,3-diyl)bis(5-hydroxypentanamide)
• 英文别名: 5-hydroxy-N-[2-hydroxy-3-(5-hydroxypentanoylamino)propyl]pentanamide
• CAS: 220648-39-5
• 化学式: C₁₃H₂₆N₂O₅
• 分子量: 290.36
• InChiKey: CWKYRLNNABUUDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N′-(2-hydroxypropane-1,3-diyl)bis(5-hydroxypentanamide) 在 吡啶 、 1,2,3,4-四氢萘 作用下， 反应 5.0h， 生成 N-<5-(9-fluorenylmethoxycarbonyloxy)valeroyl>-N'-<5-(4,4'-dimethoxytrityloxy)valeroyl>-2-O-(N,N-diisopropylamino-2-cyanoethoxyphosphinyl)-1,3-diamino-2-propanol
  参考文献：
  名称：

  Shchepinov, Mikhail S.; Southern, Edwin M., Russian Journal of Bioorganic Chemistry, 1998, vol. 24, # 10, p. 706 - 709

  摘要：

  DOI：
• 作为产物：
  描述：

  delta-戊内酯 、 1,3-二氨基-2-羟基丙烷 在 4-二甲氨基吡啶 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以79%的产率得到N,N′-(2-hydroxypropane-1,3-diyl)bis(5-hydroxypentanamide)
  参考文献：
  名称：

  使用非核分支的亚磷酰胺合成梳形DNA †

  摘要：

  已经发现具有梳状结构的分支DNA（bDNA）在分子诊断和DNA纳米技术中具有广泛的用途。bDNA可以通过将线性DNA分子设计和组装成刚性的非共价结构，也可以使用正交保护的分支单元合成共价连接的结构来生成。尽管共价连接的结构具有优势，但由于适当保护的分支单体难以合成，该基序的使用受到了阻碍。我们报道了使用容易获得的δ-维拉内酯和1,3-二氨基丙烷-2-醇可轻松合成具有正交DMT和Lev保护基的支化单体。使用该支化单体，合成具有三个不同DNA臂的梳状bDNA。通过使用荧光标记的互补和错配DNA探针的荧光显微镜评估bDNA的合成和杂交能力。方便地使用正交保护的分支单体有望加速bDNA在诊断，生物传感，基因谱分析，DNA计算，多色成像和纳米技术等领域的应用。

  DOI：

  10.1039/c8ob00626a

文献信息

• Multi-sequence capture system
  申请人：University of Utah Research Foundation

  公开号：US10465242B2

  公开（公告）日：2019-11-05

  Systems, devices, and methods for capturing single source-specific biological material from a multi-source aggregate of biological material are disclosed and discussed. A capture system is generated using reversible chain-blocking to make capture substrates having substrate-linked populations of capture molecules specific for molecules of interest. Incubating such capture substrates in the presence of only a single source of biological material facilitates the association of molecules of interest from the same source. Capture substrate-specific barcode sequences coupled to the capture molecules allow multisource aggregate processing and subsequent grouping to retain the source-specific information following downstream processing.

  本文公开并讨论了从生物材料的多源集合体中捕获单源特异性生物材料的系统、装置和方法。利用可逆链阻断生成捕获系统，使捕获基质具有特异于感兴趣分子的捕获分子基质连接群。在仅有单一生物材料源的情况下孵育这种捕获基质，可促进来自同一来源的相关分子的结合。与捕获分子相连的捕获基质特异性条形码序列允许进行多源聚合处理和后续分组，以便在下游处理后保留源特异性信息。
• Multimeric oligonucleotide compounds
  申请人：Translate Bio MA, Inc.

  公开号：US10704046B2

  公开（公告）日：2020-07-07

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.

  本公开提供了多聚物寡核苷酸化合物，包括两个或多个靶向特异性寡核苷酸（如反义寡核苷酸（ASO）），每个寡核苷酸都具有抗裂解性，并通过可裂解连接体连接在一起。特别是两个或更多链接的靶标特异性寡核苷酸，每个都针对不同的靶标，可以同时抑制多个基因的表达水平，同时表现出良好的药代动力学和药效学特性。还提供了所述化合物的制造方法和用途。
• MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
  申请人：Translate Bio MA, Inc.

  公开号：EP2756080B1

  公开（公告）日：2019-02-20
• MULTIMERIC OLIGONUCLEOTIDES COMPOUNDS
  申请人：Uhlmann Eugen

  公开号：US20150299695A1

  公开（公告）日：2015-10-22

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
• METHODS OF DELIVERING MULTIPLE TARGETING OLIGONUCLEOTIDES TO A CELL USING CLEAVABLE LINKERS
  申请人：RaNA Therapeutics, Inc.

  公开号：US20150315588A1

  公开（公告）日：2015-11-05

  The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided