2-(甲基磺酰基)-1-甲基-1-(4-甲苯磺酰基)肼 | 102396-49-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(甲基磺酰基)-1-甲基-1-(4-甲苯磺酰基)肼
• 英文名称: 2-(methylsulfonyl)-1-methyl-1-(4-tolylsulfonyl)hydrazine
• 英文别名: N,4-dimethyl-N'-methylsulfonylbenzenesulfonohydrazide
• CAS: 102396-49-6
• 化学式: C₉H₁₄N₂O₄S₂
• 分子量: 278.353
• InChiKey: KLUSMDXVECVEKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲基肼 生成 2-(甲基磺酰基)-1-甲基-1-(4-甲苯磺酰基)肼
  参考文献：
  名称：

  SARTORELLI, ALAN C.;SHYAM, KRISHNAMURTHY

  摘要：

  DOI：

文献信息

• Synthesis and evaluation of 2-substituted 1-methyl-1-(4-tolylsulfonyl)hydrazines as antineoplastic agents
  作者：Robert T. Hrubiec、Krishnamurthy Shyam、Lucille A. Cosby、Ryosuke Furubayashi、Alan C. Sartorelli

  DOI：10.1021/jm00157a033

  日期：1986.7

  Several N-2 substituted 1-methyl-1-(4-tolylsulfonyl)hydrazines were synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active compound to emerge from this study, 2-(methylsulfonyl)-1-methyl-1-(4-tolylsulfonyl)hydrazine, produced maximum percent T/C values with L1210 leukemia and B16 melanoma tumor bearing mice of 207 and 209, respectively

  合成了几种N-2取代的1-甲基-1-（4-甲苯磺酰基）肼，并评估了其对L1210白血病和B16黑色素瘤的抗肿瘤活性。该研究中最活跃的化合物2-（甲基磺酰基）-1-甲基-1-（4-甲苯磺酰基）肼在L1210白血病和B16黑色素瘤荷瘤小鼠207和209中产生最大的T / C值，分别。虽然芳基，芳烷基或烷基磺酰基部分与N-2相连导致保留了针对两种肿瘤系统的活性，但相应的苯甲酰基，4-硝基苯甲酰基和（2-硝基苯基）亚磺酰基类似物仅显示出对L1210的活性白血病。
• 1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity
  作者：Krishnamurthy Shyam、Robert T. Hrubiec、Ryosuke Furubayashi、Lucille A. Cosby、Alan C. Sartorelli

  DOI：10.1021/jm00394a040

  日期：1987.11

  A series of 1,2-bis(sulfonyl)hydrazines was synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active agent to emerge from this study, 1,2-bis(methylsulfonyl)-1-methylhydrazine, produced a maximum % T/C for mice bearing the L1210 leukemia or the B16 melanoma of 340% and 278%, respectively. Two N-chloroethyl analogues, conceived as bifunctional alkylating agents, were also synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. Although such a modification resulted in retention of antineoplastic activity against both tumor cell lines, it did not result in enhanced antineoplastic activity.
• HRUBIEC R. T.; SHYAM KRISHNAMURTHY; COSBY L. A.; FURUBAYASHI RYOSUKE; SAR+, J. MED. CHEM., 29,(1986) N 7, 1299-1301
  作者：HRUBIEC R. T.、 SHYAM KRISHNAMURTHY、 COSBY L. A.、 FURUBAYASHI RYOSUKE、 SAR+

  DOI：——

  日期：——
• SHYAM, KRISHNAMURTHY;HRUBIEC, ROBERT T.;FURUBAYASHI, RYOSUKE;COSBY, LUCIL+, J. MED. CHEM., 30,(1987) N 11, 2157-2161
  作者：SHYAM, KRISHNAMURTHY、HRUBIEC, ROBERT T.、FURUBAYASHI, RYOSUKE、COSBY, LUCIL+

  DOI：——

  日期：——