9-Bromononyltriphenylphosphonium bromide | 90052-38-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-Bromononyltriphenylphosphonium bromide
• 英文别名: Phosphonium, (9-bromononyl)triphenyl-, bromide；9-bromononyl(triphenyl)phosphanium;bromide
• CAS: 90052-38-3
• 化学式: Br*C₂₇H₃₃BrP
• 分子量: 548.341
• InChiKey: ACKJFSDDEOFXHT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.11
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-Bromononyltriphenylphosphonium bromide 在 sodium azide 作用下， 以 乙醇 为溶剂， 反应 48.0h， 以300 mg的产率得到(9-azidononyl)triphenylphosphonium bromide
  参考文献：
  名称：

  [EN] ENRICHMENT-TRIGGERED CHEMICAL DELIVERY SYSTEM
  [FR] SYSTÈME DE LIBÉRATION DE PRODUITS CHIMIQUES DÉCLENCHÉE PAR ENRICHISSEMENT

  摘要：

  本文揭示了一种化学传递系统，其中包括：i) 一种载荷化合物，其包括与第一富集基团和一个缚着的货物基团共价键合的第一反应性基团，其中第一反应性基团通过可切割的连接剂与缚着的货物基团结合；和ii) 一种触发化合物，其包括与第二富集基团和一个释放货物的基团共价键合的第二反应性基团。第一富集基团和第二富集基团在靶位点引起了载荷化合物和触发化合物的浓度增加，导致第一反应性基团与第二反应性基团之间发生双分子反应形成环化前体化合物。然后，货物基团从环化前体化合物中以一种单分子环化反应被释放。还描述了使用这种化学传递系统治疗癌症、炎症性疾病和感染等疾病的方法。

  公开号：

  WO2019084323A1
• 作为产物：
  描述：

  1,9-二溴壬烷 、 三苯基膦 在 2-甲基戊烷 、 氮气 作用下， 以 甲苯 为溶剂， 反应 18.0h， 生成 9-Bromononyltriphenylphosphonium bromide
  参考文献：
  名称：

  2,2-Dichloroalkanecarboxylic acids, processes for their production and

  摘要：

  治疗糖尿病的药物剂量，其含有公式I中的化合物作为活性物质，其中A，B，A'和W具有声明中所述的含义，公式I的新化合物以及其制备过程。

  公开号：

  US05968982A1

文献信息

• 2,2-Dichloroalkanecarboxylic acids, processes for their production and
  申请人：Roche Diagnostics GmbH

  公开号：US05968982A1

  公开（公告）日：1999-10-19

  Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I ##STR1## as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.

  治疗糖尿病的药物剂量，其含有公式I中的化合物作为活性物质，其中A，B，A'和W具有声明中所述的含义，公式I的新化合物以及其制备过程。
• Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the <i>Trypanosoma brucei</i> and <i>Trypanosoma congolense</i> Mitochondrion
  作者：Francisco José Fueyo González、Godwin U. Ebiloma、Carolina Izquierdo García、Victor Bruggeman、José María Sánchez Villamañán、Anne Donachie、Emmanuel Oluwadare Balogun、Daniel Ken Inaoka、Tomoo Shiba、Shigeharu Harada、Kiyoshi Kita、Harry P. de Koning、Christophe Dardonville

  DOI：10.1021/acs.jmedchem.6b01740

  日期：2017.2.23

  We investigated a chemical strategy to boost the trypanocidal activity of 2,4-dihydroxybenzoic acid (2,4-DHBA)- and salicylhydroxamic acid (SHAM)-based trypanocides with triphenylphosphonium and quinolinium lipophilic cations (LC). Three series of LC conjugates were synthesized that were active in the submicromolar (5a-d and 10d-f to low nanomolar (6a-f) range against wild-type and multidrug resistant strains of African trypanosomes (Trypanosoma brucei brucei and T. congolense). This represented an improvement in trypanocidal potency of at least 200-fold, and up to >10 000-fold, compared with that of non-LC-coupled parent compounds 2,4-DHBA and SHAM. Selectivity over human cells was >500 and reached >23 000 for 6e. Mechanistic studies showed that 6e did not inhibit the cell cycle but affected parasite respiration in a dose-dependent manner. Inhibition of trypanosome alternative oxidase and the mitochondrial membrane potential was also studied for selected compounds. We conclude that effective mitochondrial targeting greatly potentiated the activity of these series of compounds.
• 2,2-DICHLORALKANCARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG DIESE ENTHALTENDE ARZNEIMITTEL, UND IHRE VERWENDUNG ZUR BEHANDLUNG DER INSULINRESISTENZ
  申请人：Roche Diagnostics GmbH

  公开号：EP0790824B1

  公开（公告）日：2002-02-06
• US5968982A
  申请人：——

  公开号：US5968982A

  公开（公告）日：1999-10-19
• ω-Substituted alkyl carboxylic acids as antidiabetic and lipid-lowering agents
  作者：Kirstin Meyer、Edgar Voss、Richard Neidlein、Hans-Frieder Kühnle、Johannes Pill

  DOI：10.1016/s0223-5234(99)80029-4

  日期：1998.10

  In screening experiments certain omega-substituted alkyl carboxylic acids were found to produce an increase in insulin-stimulated C-14-acetate incorporation into triglycerides, which may indicate an improvement in the action of insulin. Antidiabetic and lipid-lowering properties in genetically diabetic ob/ob mice demonstrated the in vivo relevance of the insulin-potentiating effects seen in vitro. The chemical structures of the w-substituted alkyl carboxylic acids with insulin-potentiating effects correspond to the general formula ring-spacer-COOH. A close structure-activity relationship was observed. The most potent compound in ob/ob mice was 3e, which normalized blood glucose as well as hyperinsulinaemia and lowered serum triglycerides and cholesterol by 52% and 37%, respectively. On the basis of these results, omega-substituted alkyl carboxylic acids are interesting as a new class of oral antidiabetic agents with insulin-sensitizing and lipid-lowering activity. (C) Elsevier, Paris.