12-(2,4,6-triiodophenoxy)dodecanoic acid | 500711-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 12-(2,4,6-triiodophenoxy)dodecanoic acid
• CAS: 500711-82-0
• 化学式: C₁₈H₂₅I₃O₃
• 分子量: 670.108
• InChiKey: ASUQKWSNPUTSNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  12-溴十二烷酸 、 2,4,6-三碘苯酚 在 氢氧化钾 、 盐酸 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 12.0h， 以60%的产率得到12-(2,4,6-triiodophenoxy)dodecanoic acid
  参考文献：
  名称：

  1,3-GLYCERIDE COMPOUND HAVING TWO IODOPHENYL GROUPS

  摘要：

  公开号：

  EP1426353B1

文献信息

• 1,3-glyceride compound having two iodophenyl groups
  申请人：Takahashi Kazunobu

  公开号：US20050002864A1

  公开（公告）日：2005-01-06

  A compound represented by the following general formula (I) or a salt thereof: wherein Ar 1 and Ar 2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L 1 and L 2 independently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents —CH(OH)— or —CO—, which is suitable for an iodine-containing contrast medium containing liposomes.

  以下为一般式(I)所表示的化合物或其盐： 其中Ar1和Ar2分别表示带有至少一个碘原子的取代或未取代芳基基团；L1和L2分别表示二价桥接基团，其主链由至少7个原子组成，其中至少一个为杂原子；而X表示—CH(OH)—或—CO—，适用于含碘造影剂的脂质体。
• Glycerol ester derivative
  申请人：Takahashi Kazunobu

  公开号：US20060062726A1

  公开（公告）日：2006-03-23

  A compound represented by the following general formula (IA) or a salt thereof: wherein Ar 1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar 2 represents an aryl group having at least one iodine atom as a substituent; L 1 and L 2 independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L 3 represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L 3 is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

  以下是通用式（IA）或其盐所代表的化合物：其中Ar1代表氢原子或含有至少一个碘原子的芳基基团；Ar2代表含有至少一个碘原子的芳基基团；L1和L2分别独立地表示一个二价桥接基团，其主链包含6个或更多个碳原子；L3表示单键或一个二价桥接基团，其主链包含1至6个碳原子和一个氧原子；X表示一个含有至少一个杂原子的功能基团，但当L3为单键时，X表示除羟基以外的功能基团。该化合物可以用作脂质体的膜组分，而脂质体可以用作X射线造影的对比剂。
• 1,3-minus;GLYCERIDE COMPOUND HAVING TWO IODOPHENYL GROUPS
  申请人：Fuji Photo Film Co. Ltd.

  公开号：EP1426353A1

  公开（公告）日：2004-06-09

  A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents -CH(OH)- or -CO-, which is suitable for an iodine-containing contrast medium containing liposomes.

  由以下通式(I)代表的化合物或其盐： 其中 Ar1 和 Ar2 独立地代表取代或未取代的芳基，该芳基至少有一个碘原子作为取代基；L1 和 L2 独立地代表二价桥基，该桥基的主链由 7 个或更多原子组成，其中至少有一个原子是杂原子；X 代表-CH(OH)- 或-CO-，适用于含有脂质体的含碘造影剂。
• [EN] GLYCEROL ESTER DERIVATIVE<br/>[FR] DERIVE D'ESTER DE GLYCEROL
  申请人：FUJI PHOTO FILM CO LTD

  公开号：WO2003080554A2

  公开（公告）日：2003-10-02

  A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2 represents an aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L3 represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L3 is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

  一种由以下通式(IA)表示的化合物或其盐： 其中，Ar1代表氢原子或至少具有一个碘取代基的芳基；Ar2代表至少具有一个碘取代基的芳基；L1和L2各自独立地代表一种主链含有6个或更多碳原子的二价桥接基团；L3代表单键或一种主链含有1至6个碳原子和一个氧原子的二价桥接基团；X代表包含至少一个杂原子的功能基团，前提是，当L3为单键时，X代表羟基以外的功能基团。该化合物可用于制备脂质体的膜成分，而所述脂质体可用作X射线摄影的对比剂。
• IODINATED TRIGLYCERIDE ANALOGS
  申请人：FUJIFILM Corporation

  公开号：EP1492776B1

  公开（公告）日：2008-10-29