2-Vinyl-4-isopropyl-2-oxazolin-5-on. | 13112-24-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Vinyl-4-isopropyl-2-oxazolin-5-on.
• 英文别名: 2-Vinyl-4-isopropyl-Δ²-oxazolinon-(5)；4-isopropyl-2-vinyl-4H-oxazol-5-one；2-ethenyl-4-propan-2-yl-4H-1,3-oxazol-5-one
• CAS: 13112-24-8
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: WIGIJRIQAUFFCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基-2-(丙-2-烯酰氨基)丁酸 在 乙酸酐 作用下， 反应 0.08h， 生成 2-Vinyl-4-isopropyl-2-oxazolin-5-on.
  参考文献：
  名称：

  拟恶唑酮的新型制备方法

  摘要：

  在过量乙酸酐中，由N-丙烯酰基和N-甲基丙烯酰基-α-氨基酸制得2-烯基-2-恶唑啉-5-酮，同时与等摩尔量的乙酸酐在吡啶中反应，得到新的拟恶唑酮2 -亚烷基-3-恶唑啉-5-酮是由相同的N-酰基-α-氨基酸高产率合成的。通过IR，NMR和UV光谱区分5-恶唑酮。讨论了产生的5-恶唑酮与用作起始原料的N-酰基-α-氨基酸之间的结构关系。

  DOI：

  10.1016/s0040-4020(01)92303-8

文献信息

• Surface treatment of silicone medical devices with reactive hydrophilic polymers
  申请人：——

  公开号：US20020120084A1

  公开（公告）日：2002-08-29

  The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.

  本发明用于硅胶医疗器械（如隐形眼镜和医疗植入物）的表面处理。特别是，本发明涉及一种方法，通过亲水性聚合物上的反应官能团与医疗器械表面或附近的反应官能团之间的反应，在医疗器械表面涂上亲水性聚合物，从而改变医疗器械的表面，增加其生物相容性或亲水性。本发明还涉及具有这种表面涂层的隐形眼镜或其他医疗设备。
• Method for applying polymeric lens coating
  申请人：——

  公开号：US20030068433A1

  公开（公告）日：2003-04-10

  The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device at reaction temperatures of less than about 55°C.

  本发明旨在对隐形眼镜和医疗植入物等医疗器械进行可再生的表面处理。具体而言，本发明涉及一种改性医疗器械表面以增加其生物相容性或亲水性的方法，其方法是通过亲水性聚合物上的反应性官能团与医疗器械表面或其附近的反应性官能团在反应温度低于约 55°C 时发生互补反应，在医疗器械表面涂上可去除的亲水性聚合物。
• Surface treatment for silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating
  申请人：Bausch & Lomb Incorporated

  公开号：US20030224185A1

  公开（公告）日：2003-12-04

  The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone medical device by sequentially subjecting the surface of the lens to plasma polymerization in a hydrocarbon-containing atmosphere and then covalently attaching a preformed hydrophilic polymer to the surface of the carbon coating. The invention is especially useful for forming a biocompatible coating on a silicone contact lens.

  本发明通过在含碳氢化合物的气氛中对镜片表面进行等离子聚合，然后将预成型的亲水性聚合物共价连接到碳涂层表面，从而在硅胶医疗设备表面提供了一种光学上透明的亲水涂层。本发明尤其适用于在硅胶隐形眼镜上形成生物相容性涂层。
• Surface treatment utilizing microwave radiation
  申请人：Bausch & Lomb Incorporated

  公开号：US20040166232A1

  公开（公告）日：2004-08-26

  This invention provides a method of modifying the surface of a medical device, such as an ophthalmic lens. The method involves contacting a surface of the medical device with a solution containing a surface modifying agent; and subjecting the device surface and surface modifying agent to microwave radiation while the surface modifying agent is in contact with the device surface. The device may be constructed of materials such as hydrogel copolymers and silicone materials.

  本发明提供了一种改性医疗设备（如眼科镜片）表面的方法。该方法包括将医疗设备的表面与含有表面改性剂的溶液接触；在表面改性剂与设备表面接触时，将设备表面和表面改性剂置于微波辐射下。该装置可以由水凝胶共聚物和硅树脂材料等材料制成。
• A novel preparation of pseudoxazolones
  作者：Yoshio Iwakura、Fujio Toda、Yoshinori Torii

  DOI：10.1016/s0040-4039(00)70054-2

  日期：1966.1